Navigation Links
Cancer Cell Article Demonstrates First Definitive Evidence for Targeting of Pol I as New Approach to Cancer Therapy
Date:7/10/2012

ac later this year."

The Cancer Cell publication highlighted a number of potential competitive advantages of CX-5461.  An unanticipated finding was that malignant cells are considerably more dependent upon maintenance of high levels of Pol I activity than previously believed, and even modest inhibition of Pol I triggers cancer cell death. These results suggest that selective activation of a surveillance pathway to activate p53, using Pol I inhibitors such as CX-5641, is likely to be therapeutically useful in the treatment of a wide range of tumors. In addition, as a cancer-specific inducer of p53, CX-5461 was shown to be 300 times more potent than currently studied non-genotoxic p53 activators with alternate mechanisms.

About Pol I and CX-5461 CX-5461 is a first-in-class, selective small molecule inhibitor of RNA polymerase I (Pol I) that triggers a stress surveillance pathway to activate p53 in cancer cells. The tumor suppressor protein p53, known as "the guardian of the genome," orchestrates cellular responses to diverse stress factors. Activation of this protein can lead to cell cycle arrest or cell death and it is pivotal in determining whether cancer cells proliferate or die. CX-5461 inhibits upregulated Pol I transcription in cancer cells, causing the release of ribosomal proteins (RP) from the nucleolus. These RP then bind to Mdm2, liberating p53 from the Mdm2-p53 complex to induce apoptosis in cancer cells. Non-genotoxic activation of p53 has long been an attractive approach to treating cancers, but it has not yet been successfully exploited in the clinic. CX-5461 has therapeutic potential in both solid tumor and hematological malignancies, yet hematologic cancers, the vast majority of which have wild-type p53 status, are exquisitely sensitive to CX-5461 and represent the clearest path to clinical proof of concept.

About Cylene Pharmaceuticals Cylene Pharmaceuticals is a clinical stage private company developing small molecu
'/>"/>

SOURCE Cylene Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. QIAGEN Achieves Personalized Healthcare Milestone with U.S. Approval of Companion Diagnostic for Colorectal Cancer
2. Oncos Therapeutics Announces Clinical Advisory Board for its Oncolytic Virus and Cancer Immunotherapy Development Programs
3. Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020
4. Global Kidney Cancer Drugs Industry
5. Trovagene to Study Trans-Renal KRAS Mutation Detection in Pancreatic Cancer
6. Prostate Cancer Center of New Jersey the Latest Center to Achieve High Honor of ACR-ASTRO Accreditation
7. Lifeline Biotechnologies, Inc. Receives Patent Award, a Device for Breast Tissue Temperature Analysis for Determining Cancer Conditions
8. U.S. FDA Grants Priority Review to the New Drug Application for Bayers Regorafenib to Treat Patients with Metastatic Colorectal Cancer
9. Aethlon Medical (AEMD) Note: Cancer Treatment Publication Authored by Aethlon Medical Researchers Now Available
10. Elektas Gamma Knife and Radiation Therapy Systems for Cancer Treatment Take Top Three Places in 2012s Best in KLAS for Radiation Therapy
11. Healthscope to commercially launch Circadians Cancers of Unknown Primary Diagnostic Test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... JERUSALEM , April 27, 2015 ... successfully completed filing of a Pre-Marketing Notification Application (510k) ... its BRH-A2 Wound Management System. BRH Medical expects feedback ... entering the US market with BRH-A2 following FDA pre-market ... Motti Oderberg , CEO for BRH ...
(Date:4/27/2015)... , April 27, 2015 - ... Process Patent by the State Intellectual Property Office of ... Based on Pooling Technology  - A New Treatment ... (CLI)    - About 20% of Elderly Urban ... in Women is Substantially Higher Than in Men. CLI is ...
(Date:4/26/2015)... April 26, 2015  Ikonopedia announced today that ... system have been selected for use by BelleBridge, ... screening and diagnostic examinations. Ikonopedia will showcase its ... of Breast Imaging,s SBI/ACR Breast Imaging Symposium in ... 2015 (SBI Booth #216). BelleBridge is ...
Breaking Medicine Technology:BRH Medical, Ltd., Announces Filing of a Pre-Market Submission with the US Food and Drug Administration (FDA) for the BRH-A2 Tissue Management System 2Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 2Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 3Stempeutics Gets Stem Cell Patent in China (Chinese Application Number: CN201080053627) for its Novel Stem Cell Drug 'Stempeucel' 4Ikonopedia Selected to Provide Breast Imaging Report Generation Capabilities for BelleBridge's Breast Telemedicine Services 2Ikonopedia Selected to Provide Breast Imaging Report Generation Capabilities for BelleBridge's Breast Telemedicine Services 3Ikonopedia Selected to Provide Breast Imaging Report Generation Capabilities for BelleBridge's Breast Telemedicine Services 4
... of human-animal hybrids to generate stem cells WORCESTER, ... Pink Sheets: ACTC) and its collaborators reported today that ... reprogram adult human cells. The research, which appears online ... Stem Cells (Editor-in-Chief: Sir Ian Wilmut; published by ...
... Men who experience erectile dysfunction between the ages of ... disease than men without dysfunction, according to a new Mayo ... have an 80 percent higher risk of heart disease. "The ... says researcher Jennifer St. Sauver, Ph.D. The study was published ...
Cached Medicine Technology:Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 2Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 3Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 4Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs 5Mayo Clinic Study Finds Younger Men With Erectile Dysfunction at Double Risk of Heart Disease 2Mayo Clinic Study Finds Younger Men With Erectile Dysfunction at Double Risk of Heart Disease 3
(Date:4/27/2015)... Attorney Dan Newlin, of the Law Offices ... clients, took that commitment to a whole new level with ... it easier for existing and potential clients to contact the ... and added value to the firm’s services, #Dan covers Central ... has law offices. , “I knew the pound sign (#) ...
(Date:4/27/2015)... 27, 2015 Texas has saved $433 ... drug offenders to providing drug offenders with addiction treatment, ... on April 8th. Several states, including Massachusetts, are considering ... incarceration. Texas has formed community recovery programs to help ... The Council of State Governments WA, ID, NE, ...
(Date:4/27/2015)... 2015 Climate change predictions are largely ... the number of variables used and the availability of ... water researcher Gerald Pollack, PhD, and Climatologist L.DeWayne Cecil, ... Water® radio show, noted three potential weaknesses that could ... of these individuals dispute that Earth’s climate is changing. ...
(Date:4/27/2015)... Winscribe Professional for Windows Phones ... mobile speech productivity technology, which also includes applications ... , Winscribe has supported mobile dictation ... With the latest enhancement, Winscribe Professional for ... interface in the last ten years. The ...
(Date:4/27/2015)... PREVENT Life Safety, America’s premier provider ... with the addition of an account manager in Houston. ... a growing customer base, Curtis Rice, an experienced sales ... Account Manager. Curtis has been added to the team ... the Houston area and beyond. , Curtis ...
Breaking Medicine News(10 mins):Health News:Dan Newlin Hashtags It With #Dan 2Health News:Texas Saves $443 Million Embracing Justice Reinvestment for Drug Charges 2Health News:Texas Saves $443 Million Embracing Justice Reinvestment for Drug Charges 3Health News:Global warming: Computer weather models flawed report Climatologist, Water Researcher on Sharon Kleyne Hour™ radio show 2Health News:Global warming: Computer weather models flawed report Climatologist, Water Researcher on Sharon Kleyne Hour™ radio show 3Health News:Winscribe Professional Dictation for Smartphones Evolves as Microsoft’s Mobile OS Grows 2Health News:Winscribe Professional Dictation for Smartphones Evolves as Microsoft’s Mobile OS Grows 3Health News:Winscribe Professional Dictation for Smartphones Evolves as Microsoft’s Mobile OS Grows 4Health News:PREVENT Life Safety Services Welcomes Curtis Rice as a New Senior Account Manager in Houston, TX 2
... Bangalore, SUNNYVALE, Calif., Jan. 8 Accuray,Incorporated ... the field of radiosurgery,announced today that Healthcare Global ... for its new oncology center in,Bangalore, India. Upon ... first,CyberKnife System in India, expanding treatment access to ...
... N.J., Jan. 8 Jennifer J. Day, Senior Vice,President ... the,addition of Kenneth A. Sylvia as publisher of Current ... healthcare industry who brings to DHM,30 years of experience ... bases we serve," Day said. DHM is a subsidiary ...
... Affairs highlights large employer,s efforts to ... to treatment, PHILADELPHIA, Jan. 8 Removing ... to remain,on recommended therapies according to a new ... Health Affairs. The study, funded, in part,by GlaxoSmithKline ...
... Too Faced ... Cosmetics and FUZE Beverages, NEW YORK, Jan. 8 ... a lip gloss that keeps you both energized,and beautiful. Yes indeed ... lip gloss on the market to "fuse" beauty and fitness,benefits, this ...
... Centers and free coffee ... give blood, DETROIT, Jan. 8 In honor of ... Cross Donors,Employees and Volunteers in Michigan for two weeks in ... all donors,at any of the participating American Red Cross blood ...
... Medicaid spending slowed for first time since its inception ... The new Medicare prescription drug plan was largely responsible ... 2006, which was double the increase in spending from ... 2006, Medicare spending reached $401.3 billion, an increase from ...
Cached Medicine News:Health News:CyberKnife Radiosurgery Expands to India 2Health News:CyberKnife Radiosurgery Expands to India 3Health News:New Study Indicates Decreasing Prescription Copayments Results in Increased Adherence for Patients with Chronic Diseases 2Health News:New Study Indicates Decreasing Prescription Copayments Results in Increased Adherence for Patients with Chronic Diseases 3Health News:New Study Indicates Decreasing Prescription Copayments Results in Increased Adherence for Patients with Chronic Diseases 4Health News:New Study Indicates Decreasing Prescription Copayments Results in Increased Adherence for Patients with Chronic Diseases 5Health News:NEW! Too Faced FUZE Slenderize Guilt Free Gloss 2Health News:Dunkin' Donuts Celebrates the New Year by Supplying Goodies to Michigan's American Red Cross 2Health News:Medicare Drug Plan Fuels Health-Care Spending 2Health News:Medicare Drug Plan Fuels Health-Care Spending 3
... Studies have proven that the management of ... blood glucose levels is the most effective way ... comprehensive care aimed at maintaining or improving a ... complex and costly. , ,These have been ...
... requires making decisions about insulin dosages and ... decisions are guided by data from blood ... by the patterns that can be seen ... when the data is presented in organized ...
... Pumped Green Photocoagulator - Portable and rugged ... outpatient clinic, and operating room. Built to ... in the most demanding environments, the Novus ... A full line of accessories for ...
The ring maintains the bag tension avoiding the development of posterior capsule pleats. It is also established to compensate the efforts induced during the bag retraction....
Medicine Products: