Navigation Links
Cancer Cell Article Demonstrates First Definitive Evidence for Targeting of Pol I as New Approach to Cancer Therapy
Date:7/10/2012

ac later this year."

The Cancer Cell publication highlighted a number of potential competitive advantages of CX-5461.  An unanticipated finding was that malignant cells are considerably more dependent upon maintenance of high levels of Pol I activity than previously believed, and even modest inhibition of Pol I triggers cancer cell death. These results suggest that selective activation of a surveillance pathway to activate p53, using Pol I inhibitors such as CX-5641, is likely to be therapeutically useful in the treatment of a wide range of tumors. In addition, as a cancer-specific inducer of p53, CX-5461 was shown to be 300 times more potent than currently studied non-genotoxic p53 activators with alternate mechanisms.

About Pol I and CX-5461 CX-5461 is a first-in-class, selective small molecule inhibitor of RNA polymerase I (Pol I) that triggers a stress surveillance pathway to activate p53 in cancer cells. The tumor suppressor protein p53, known as "the guardian of the genome," orchestrates cellular responses to diverse stress factors. Activation of this protein can lead to cell cycle arrest or cell death and it is pivotal in determining whether cancer cells proliferate or die. CX-5461 inhibits upregulated Pol I transcription in cancer cells, causing the release of ribosomal proteins (RP) from the nucleolus. These RP then bind to Mdm2, liberating p53 from the Mdm2-p53 complex to induce apoptosis in cancer cells. Non-genotoxic activation of p53 has long been an attractive approach to treating cancers, but it has not yet been successfully exploited in the clinic. CX-5461 has therapeutic potential in both solid tumor and hematological malignancies, yet hematologic cancers, the vast majority of which have wild-type p53 status, are exquisitely sensitive to CX-5461 and represent the clearest path to clinical proof of concept.

About Cylene Pharmaceuticals Cylene Pharmaceuticals is a clinical stage private company developing small molecu
'/>"/>

SOURCE Cylene Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. QIAGEN Achieves Personalized Healthcare Milestone with U.S. Approval of Companion Diagnostic for Colorectal Cancer
2. Oncos Therapeutics Announces Clinical Advisory Board for its Oncolytic Virus and Cancer Immunotherapy Development Programs
3. Ovarian Cancer Therapeutics - Global Drug Forecasts and Treatment Analysis 2020
4. Global Kidney Cancer Drugs Industry
5. Trovagene to Study Trans-Renal KRAS Mutation Detection in Pancreatic Cancer
6. Prostate Cancer Center of New Jersey the Latest Center to Achieve High Honor of ACR-ASTRO Accreditation
7. Lifeline Biotechnologies, Inc. Receives Patent Award, a Device for Breast Tissue Temperature Analysis for Determining Cancer Conditions
8. U.S. FDA Grants Priority Review to the New Drug Application for Bayers Regorafenib to Treat Patients with Metastatic Colorectal Cancer
9. Aethlon Medical (AEMD) Note: Cancer Treatment Publication Authored by Aethlon Medical Researchers Now Available
10. Elektas Gamma Knife and Radiation Therapy Systems for Cancer Treatment Take Top Three Places in 2012s Best in KLAS for Radiation Therapy
11. Healthscope to commercially launch Circadians Cancers of Unknown Primary Diagnostic Test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... EASTON, Mass. , Sept. 19, 2014 /PRNewswire/ ... "Company") today announced it has received and approved ... Barozyme HT48 instruments and has begun to manufacture ... the first instrument will be ready for shipment ... be built and released at a rate of ...
(Date:9/19/2014)... 19, 2014 Aufgrund der ... äußerst erfolgreichen Serialisierungs-Countdown-Kalender aktualisiert, der jetzt auch die ... verfügbar unter pharmaserialisation.com , zeigt die Serialisierungsanforderungen ... in Kraft treten. Für international tätige ... um das "ob", sondern darum, "wann" sie die ...
(Date:9/19/2014)... and CAMBRIDGE, Mass. ... Inc. (PGDx), a provider of advanced cancer ... Medicines , a leader in discovering and developing ... today disclosed the first-ever comprehensive genomic study of ... deadly cancer of the female reproductive system, also ...
Breaking Medicine Technology:Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3Pharma IQ stellt weltweite Serialisierungsfristen in seinen Countdown-Kalender 2014 - 2018 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 2First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 3First Discovery Of Actionable Genetic Alterations In A Deadly Cancer Reported By Personal Genome Diagnostics And Blueprint Medicines 4
(Date:9/19/2014)... NY (PRWEB) September 19, 2014 Ticket ... presale tickets for her 2015 “Honeymoon” Tour. This ... ARIANA-2015 for additional savings at the checkout. , Ariana Grande ... MO (Independence Event Center) , Feb. 28, 2015: Milwaukee, WI ... MN (Xcel Energy Center) , March 03, 2015: Chicago, IL ...
(Date:9/19/2014)... Sept. 19, 2014 York University researchers say ... can help to detect heightened risk for developing ... are any telltale behavioural signs of dementia., Faculty ... Kara Hawkins who led the study asked the ... cognitive-motor tasks, on dual screen laptop computers. The ...
(Date:9/19/2014)... 2014 The Relaxation Drink Production ... 2014. Industry operators were able to mass produce their ... well as establish distribution contracts with nation-wide retailers. The ... to its novelty; energy drinks have only been in ... operators have been able to establish brands and grow ...
(Date:9/19/2014)... San Jose, California (PRWEB) September 19, 2014 ... – Buoyed by technological advancements, surgical techniques, and ... become the preferred treatment for several chronic diseases ... liver. Advancements in organ and tissue transplantation have ... patients. Organ transplant today represents a ...
(Date:9/19/2014)... grow well in infertile land, and bear many beans ... is because most legumes have a symbiotic relationship with ... air and then supply the host plant with ammonia ... organs called nodules in their roots. However, if too ... the growth of the plants, because the energy cost ...
Breaking Medicine News(10 mins):Health News:Ariana Grande Tickets in Miami, Philadelphia, Chicago, Saint Paul, Fairfax, Uncasville, Orlando, San Jose, New York, Detroit, San Antonio, Pittsburgh, Atlanta & Dallas 2Health News:Ariana Grande Tickets in Miami, Philadelphia, Chicago, Saint Paul, Fairfax, Uncasville, Orlando, San Jose, New York, Detroit, San Antonio, Pittsburgh, Atlanta & Dallas 3Health News:Ariana Grande Tickets in Miami, Philadelphia, Chicago, Saint Paul, Fairfax, Uncasville, Orlando, San Jose, New York, Detroit, San Antonio, Pittsburgh, Atlanta & Dallas 4Health News:Simple test can help detect Alzheimer's before dementia signs show: York U study 2Health News:Relaxation Drink Production in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Relaxation Drink Production in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Growing Number of Terminally Ill Patients Drive the Global Organ and Tissue Transplantation Market, According to New Report by Global Industry Analysts, Inc. 2Health News:Growing Number of Terminally Ill Patients Drive the Global Organ and Tissue Transplantation Market, According to New Report by Global Industry Analysts, Inc. 3Health News:Growing Number of Terminally Ill Patients Drive the Global Organ and Tissue Transplantation Market, According to New Report by Global Industry Analysts, Inc. 4Health News:Long-distance communication from leaves to roots 2
... (BUSM) and Boston Medical Center (BMC) found that patients ... of any type did not experience serious harm. However, ... obstetrics/gynecology setting received the most benefit. The findings, which ... , also conclude that disclosures made in an emergency ...
... controversial because of cost, number of false positives, study ... an electrocardiogram in screenings for heart disorders in competitive ... sudden cardiac death and save lives, say Italian researchers. ... dies every three days from an undetected cardiovascular disorder, ...
... commitment to helping its members lead ... ... of,Oregon announces that it has won four bronze (second-place) Telly Awards,for ... Web site for Regence members. The Telly Awards are widely,considered to ...
... risks , , THURSDAY, July 3 (HealthDay News) -- Doing ... health, a new study shows. , Researchers at the ... had bigger spikes in blood pressure than well-rested people ... regard a task as worthwhile and achievable, they increase ...
... Minn., July 3 The Minnesota Nurses,Association (MNA) announced ... U.S. House of Representatives, Congressional District 3., "Ashwin ... and,he will fight for reforms that will produce real ... Committee Chair, Tom Kelly, RN.,"With his unequivocal support of ...
... July 3 The Minnesota Nurses,Association (MNA) announced ... for U.S. House of Representatives, Congressional District 6., ... he shares a guiding principle,important to Minnesota nurses: ... ability to obtain healthcare," said MNA Political Committee,Chair, ...
Cached Medicine News:Health News:Disclosing violence to primary care or obestetrics/gynecology physicians most beneficial 2Health News:Screening Athletes Could Cut Sudden Cardiac Death Risk 2Health News:Regence Wins Four International Telly Awards for Health and Wellness Videos 2Health News:Working Hard When Tired Raises Blood Pressure 2Health News:Minnesota Nurses Association Endorses Ashwin Madia for Congress 2Health News:Minnesota Nurses Association Endorses Elwyn Tinklenberg for Congress 2
Produce clean 0.75 mm round hole without tissue tags. Serrated squeeze action handle....
Target illumination for day and night testing. Glare luminance distance. The Optec 3500 remote control offers flexible positioning during test administration. Each vision tester includes 12 tests sli...
... The CSV- lOOOHGT instrument provides standardized glare testing. ... Vectorvision test faces for the evaluation of glare ... is precisely calibrated to simulate two on-coming halogen ... feet. The glare level can be adjusted to ...
Ruler S/Steel....
Medicine Products: