Navigation Links
Cambridge Scientists Archive 500,000th Crystal Structure
Date:12/10/2009

CAMBRIDGE, England, December 10 /PRNewswire/ -- The Cambridge Crystallographic Data Centre (CCDC) is proud to announce an important milestone in the history of crystallography - the archiving of the 500,000th small molecule crystal structure to the Cambridge Structural Database (CSD). This unique, scientifically rigorous database, built over 45 years, is the international de facto standard for small-molecule chemical structures and has become an essential resource to scientists around the world.

Professor Sir David King, former Chief Scientific Adviser to the UK Government, and Chairman of the CCDC Board of Governors 1998-2000, notes that "The timely development of CCDC and the Cambridge Structural Database from very humble beginnings 45 years ago to become the key global source for crystal structures makes a remarkable story. The user-friendliness and versatility of the database has become the major resource for the chemical and pharmaceutical industries, and in the process has transformed their capability."

The CSD System incorporates a suite of flexible search and analysis tools allowing chemical knowledge to be extracted from the raw crystallographic data. Information derived from small-molecule crystal structures is vital to structural chemistry research in its broadest sense, and in particular to pharmaceutical drug discovery, materials design, drug development and formulation. The database is also a rich resource for teachers and has application across the entire span of the chemistry curriculum. There are clear indications that this knowledge will be equally vital in the development of future materials, such as gas-storage systems, and will play a key role in the development of nano- and green-technologies.

Dr Colin Groom, Executive Director of the CCDC says that "the determination of 500,000 crystal structures is a remarkable achievement. However, the scientific community is hungry for the next 500,000 and the knowledge these will undoubtedly bring. As the CSD grows both in size and in the complexity of structures it contains, the database not only helps us to answer our questions about molecular structure and interactions, but tells us what those questions should be."

The CSD's 500,000th structure is the anti-convulsant drug Lamotrigine (Lamictal(R)) which was discovered by GlaxoSmithKline and approved by the US FDA for the treatment of epilepsy in 1994 and additionally for the treatment of bipolar I disorder in 2003. The structure can be viewed at http://www.ccdc.cam.ac.uk/halfmillionthstructure

Crystal structure of Lamotrigine

About The Cambridge Crystallographic Data Centre

Originating in the Department of Chemistry at the University of Cambridge, and with UK Government funding, the CCDC is now a fully independent institution constituted as a non-profit company and a registered charity since 1989. The CCDC is financially independent, through annual subscriptions received for CSD System access from academia and industry. The CCDC has a strong track record in basic research through more than 700 peer-reviewed publications, and these papers have attracted more than 18,000 citations in the international scientific literature. More than 1,500 CSD applications papers by non-CCDC authors have been similarly well received.

Web: http://www.ccdc.cam.ac.uk

SOURCE The Cambridge Crystallographic Data Centre


'/>"/>
SOURCE The Cambridge Crystallographic Data Centre
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Cambridge-based Ligon Discovery Raises $1M in Seed Funding
2. Cambridge Laboratories Announces Approval of Tetrabenazine in Spain
3. Taligen Therapeutics Initiates Corporate Growth Plan with Appointment of Abbie Celniker, Ph.D., as CEO and Establishment of Cambridge, Mass., Headquarters
4. New Amgen Scholars Web site Launches to Build a Global Network for Future Scientists
5. Two Hutchinson Center Scientists Receive a Total of $16.7 Million for Collaborative Stem Cell Research
6. Scientists Identify Gene for Short Circuiting Excess Mucous in Lung Disease, Common Colds
7. IBM Scientists First to Image the Anatomy of a Molecule
8. Scientists Discover Origin of Malaria
9. International Journal of Occupational and Environmental Health Features Discovery of Asbestos-Related Pain Origin from Scientists at the Karmanos Cancer Institute in Detroit
10. Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy
11. Scientists Discover a Role for the Growth Factor TGF-beta in Maintaining Health of Retinal Blood Vessels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... , June 24, 2016  Consumers have taken ... regulators/payers have placed more emphasis on patient outcomes. ... support programs in the pharmaceutical industry have evolved ... Consequently, pharmaceutical companies are focusing on becoming more ... providing products and services that improve health. ...
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... 24, 2016 ... the addition of the " Global Markets for ... This report focuses on ... updated review, including its applications in various applications. The ... which includes three main industries: pharmaceutical and biotechnology, food ...
Breaking Medicine Technology:
(Date:6/25/2016)... ... ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter of indulgence ... high can result in disappointment, perhaps even self-loathing. However, those who set the bar ... from PsychTests.com reveals that behind the tendency to set low expectations is ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty Network, ... M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... the most handsome men, look naturally attractive. Plastic surgery should be invisible.” He ...
Breaking Medicine News(10 mins):