Navigation Links
Calixa Therapeutics to Make Multiple Presentations on CXA-101 and CXA-101/tazobactam at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
Date:9/11/2009

SAN DIEGO, Sept. 11 /PRNewswire/ -- Calixa Therapeutics Inc., a clinical-stage biopharmaceutical company focused on the development and commercialization of novel antibiotics for the treatment of antibiotic-resistant infections, will present pre-clinical and clinical data in 20 posters at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) that is being held in San Francisco on September 12 to 15, 2009. The presentations will include comprehensive in vitro, in vivo, and clinical data on Calixa's anti-pseudomonal cephalosporin, CXA-101, alone and in combination with the beta-lactamase inhibitor, tazobactam.

CXA-101 is a potent, intravenously administered, anti-pseudomonal cephalosporin currently in Phase 2 study for the treatment of complicated urinary tract infections. Calixa recently initiated a Phase 1 study in healthy subjects for a second product, CXA-101/tazobactam. Tazobactam is a well established beta-lactamase inhibitor that could further enhance the excellent antibacterial activity of CXA-101 and potentially increase its clinical utility.

"This is an outstanding achievement for Calixa," said James Ge, M.D., Ph.D., chief scientific officer and executive vice president, of Calixa. "The 20 presentations give us a very strong presence at this major infectious disease conference, and reflect significant progress over the past year. We are particularly enthusiastic about the excellent clinical safety and pharmacokinetics profile CXA-101 exhibited in the Phase 1 studies conducted to date. We look forward to moving this promising compound, alone and in combination with tazobactam, to the next stages of clinical development."

The 20 presentations (F1-1985 to F1- 2004) relating to Calixa's antibiotic compounds will be presented in the Poster Session, Investigational Cephalosporins (Tuesday, September 15, 2009, 9:00 to 11:00 AM PDT). The titles of the presentations are as follows:

F1-1985: Affinity of the New Cephalosporin CXA-101 to Penicillin-Binding Proteins of Pseudomonas aeruginosa

F1-1986: Activity Profile of CXA-101 and CXA-101/Tazobactam against Target Gram-Positive and Gram-Negative Pathogens

F1-1987: Activity of the New Cephalosporin CXA-101 against Carbapenem-Resistant Pseudomonas aeruginosa Isolates from a Spanish Multicenter Study

F1-1988: CXA-101 has High Activity against Clinical Isolates of Pseudomonas aeruginosa Including Ceftazidime-Resistant Isolates

F1-1989: Activity of CXA-101 against Pseudomonas aeruginosa beta-lactam Resistance Mechanisms: ampD, ampDh2, ampDh3, dacB (PBP4), and oprD Mutations

F1-1990: Activity of the New Cephalosporin CXA-101 against Biofilms of Relevant P. aeruginosa Phenotypes in Cystic Fibrosis Chronic Respiratory Infection: Mucoid and Hypermutable Strains

F1-1991: Activity of the New Cephalosporin CXA-101 against Biofilms of Relevant P. aeruginosa Phenotypes in Cystic Fibrosis Chronic Respiratory Infection: Mucoid and Hypermutable Strains

F1-1992: Activity of the Novel Cephalosporin CXA-101 Tested in Combination with Tazobactam against Cephalosporin-resistant Enterobacteriaceae, P. aeruginosa and B. fragilis

F1-1993: Activity of CXA-101 plus Tazobactam against ESBL-Producing Escherichia coli and Klebsiella pneumoniae

F1-1994: Chequerboard Titrations of Cephalosporin CXA-101 (FR264205) and Tazobactam vs. Beta-lactamase-producing Enterobacteriaceae

F1-1995: FIC Index Determination of CXA-101/Tazobactam in Combination with Amikacin, Aztreonam, Meropenem, Levofloxacin, and Tigecycline against E. coli, K. pneumoniae, and P. aeruginosa Strains.

F1-1996: In Vitro Assessment Using Time-kill Curves of CXA-101 (CXA)/Tazobactam (TAZ) Against Escherichia coli (EC), Klebsiella pneumoniae (KP), and Pseudomonas aeruginosa (PA) Strains

F1-1997: Quality Control Parameters for CXA-101 Broth Microdilution Susceptibility Tests

F1-1998: Disk Diffusion Testing of CXA-101 and CXA-101 in Combination with Tazobactam against Target Pathogens

F1-1999: In Vivo Activity of CXA-101 plus a 2:1, 4:1, or 8:1 Ratio of Tazobactam against Various Enterobacteriaceae Producing Extended-Spectrum Beta-Lactamases in the Thighs of Neutropenic Mice

F1-2000: 50% Effective Dose Determination of CXA-101 Alone or in Combination with Tazobactam for Treating Experimental Peritonitis in Mice Due to ESBL-Producing Escherichia coli strains: Comparison with Ceftazidime and Piperacillin/Tazobactam

F1-2001: Pharmacokinetics Study of CXA-101 (CXA) in Combination with Tazobactam in Dogs after Intravenous Administration

F1-2002: In Vivo Activity of CXA-101, a New Cephalosporin, against Pseudomonas aeruginosa and other Enterobacteriaceae in the Thighs of Neutropenic Mice

F1-2003: CXA-101 Population PK Analysis and Monte Carlo Simulation for PK/PD Target Attainment and Dose Regimen Selection

F1-2004: The Pharmacokinetics and Safety of CXA-101, a New Anti-pseudomonal Cephalosporin, in Healthy Adult Male and Female Subjects Receiving Single- and Multiple-Dose Intravenous Infusions

About Calixa Therapeutics

Calixa Therapeutics, Inc. is a biopharmaceutical company committed to the development and commercialization of novel medicines for the treatment of infectious diseases. The company's initial focus is on developing novel antibiotics for use in the hospital setting. Calixa Therapeutics, which is privately held, is headquartered in San Diego and has operations in the San Francisco Bay Area. For additional information, please visit: www.calixainc.com.

    Contacts:
    Robert Flamm, Ph.D., or David Schull
    Russo Partners
    (212) 845-4226
    robert.flamm@russopartnersllc.com
    david.schull@russopartnersllc.com

    Eckard Weber, M.D.
    Calixa Therapeutics Inc.
    (858) 480-2420
    stone@domainvc.com


'/>"/>
SOURCE Calixa Therapeutics Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Calixa Therapeutics Announces Positive Phase 1 Results for CXA-101, a Novel Intravenous Cephalosporin Antibiotic with Excellent Anti-Pseudomonal Activity
2. Calixa Therapeutics Announces Initiation of Phase 2 Clinical Trial of Its Antibiotic, CXA-101, in Patients with Complicated Urinary Tract Infections
3. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Amicus Therapeutics Announces Second Quarter 2007 Financial Results
6. TorreyPines Therapeutics Completes Patient Enrollment in Phase IIb Clinical Trial of Tezampanel for the Treatment of Acute Migraine Headache
7. CV Therapeutics Announces Eight Abstracts Accepted for Presentation at the European Society of Cardiology Congress 2007
8. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
9. Protalix BioTherapeutics Treats First Patient in Phase III Clinical Trial of prGCD
10. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
11. TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2017)... May 4, 2017  DarioHealth Corp. (NASDAQ: DRIO), a ... big data solutions, today announced that it is teaming ... STI Technologies Limited to lower diabetes healthcare costs in ... innoviCares card, which is available throughout all provinces and ... will be eligible for additional savings when shopping for ...
(Date:5/3/2017)... 2017 A Catheterization Laboratory is an ... facility. Commonly referred to as cath lab, this ... imaging technology to give physicians visual access to ... spaces, a team of physicians perform life-saving procedures ... intervention, congenital heart defect closure, stenotic heart valves, ...
(Date:5/3/2017)... Pa. , May 3, 2017  West ... in innovative solutions for injectable drug administration, announced ... Scientific Affairs and Technical Services, and Diane ... workshops and offering presentations focused on West,s expertise ... injectable products, as well as providing commentary on ...
Breaking Medicine Technology:
(Date:5/26/2017)... MN (PRWEB) , ... May 26, 2017 , ... A ... U.S. states with the healthiest seniors are located in the Midwest. With the average ... more and more people are concerned with both the quality and affordability of where ...
(Date:5/26/2017)... , ... May 26, 2017 , ... After raising nearly ... Top gadget will continue to be available at a discounted crowdfunding price on ... stress wherever they are, I also wanted to bring a fidget toy to the ...
(Date:5/26/2017)... ... May 26, 2017 , ... Dr. Alex Rabinovich, a highly-skilled oral surgeon specializing ... blog post on insurance options. If a Bay Area patient has to search for ... and money. Visiting an in-network provider for a second opinion can ensure a patient ...
(Date:5/26/2017)... , ... May 26, 2017 , ... “Just What Happened in the Garden of Eden”: ... the Garden of Eden” is the creation of published author, Penelope Colt, mother, trader, horse ... family moved to NYC when she was three. At six, they moved to Dayton, ...
(Date:5/24/2017)... ... May 24, 2017 , ... In modern research, success ... appropriate instruments for research and understanding the basic principles that were designed to ... on innovations in stereo microscopy for brightfield and fluorescence typically used in laboratories ...
Breaking Medicine News(10 mins):