Navigation Links
Calixa Therapeutics to Make Multiple Presentations on CXA-101 and CXA-101/tazobactam at the 49th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
Date:9/11/2009

SAN DIEGO, Sept. 11 /PRNewswire/ -- Calixa Therapeutics Inc., a clinical-stage biopharmaceutical company focused on the development and commercialization of novel antibiotics for the treatment of antibiotic-resistant infections, will present pre-clinical and clinical data in 20 posters at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) that is being held in San Francisco on September 12 to 15, 2009. The presentations will include comprehensive in vitro, in vivo, and clinical data on Calixa's anti-pseudomonal cephalosporin, CXA-101, alone and in combination with the beta-lactamase inhibitor, tazobactam.

CXA-101 is a potent, intravenously administered, anti-pseudomonal cephalosporin currently in Phase 2 study for the treatment of complicated urinary tract infections. Calixa recently initiated a Phase 1 study in healthy subjects for a second product, CXA-101/tazobactam. Tazobactam is a well established beta-lactamase inhibitor that could further enhance the excellent antibacterial activity of CXA-101 and potentially increase its clinical utility.

"This is an outstanding achievement for Calixa," said James Ge, M.D., Ph.D., chief scientific officer and executive vice president, of Calixa. "The 20 presentations give us a very strong presence at this major infectious disease conference, and reflect significant progress over the past year. We are particularly enthusiastic about the excellent clinical safety and pharmacokinetics profile CXA-101 exhibited in the Phase 1 studies conducted to date. We look forward to moving this promising compound, alone and in combination with tazobactam, to the next stages of clinical development."

The 20 presentations (F1-1985 to F1- 2004) relating to Calixa's antibiotic compounds will be presented in the Poster Session, Investigational Cephalosporins (Tuesday, September 15, 2009, 9:00 to 11:00 AM PDT). The titles of the presentations are as follows:

F1-1985: Affinity of the New Cephalosporin CXA-101 to Penicillin-Binding Proteins of Pseudomonas aeruginosa

F1-1986: Activity Profile of CXA-101 and CXA-101/Tazobactam against Target Gram-Positive and Gram-Negative Pathogens

F1-1987: Activity of the New Cephalosporin CXA-101 against Carbapenem-Resistant Pseudomonas aeruginosa Isolates from a Spanish Multicenter Study

F1-1988: CXA-101 has High Activity against Clinical Isolates of Pseudomonas aeruginosa Including Ceftazidime-Resistant Isolates

F1-1989: Activity of CXA-101 against Pseudomonas aeruginosa beta-lactam Resistance Mechanisms: ampD, ampDh2, ampDh3, dacB (PBP4), and oprD Mutations

F1-1990: Activity of the New Cephalosporin CXA-101 against Biofilms of Relevant P. aeruginosa Phenotypes in Cystic Fibrosis Chronic Respiratory Infection: Mucoid and Hypermutable Strains

F1-1991: Activity of the New Cephalosporin CXA-101 against Biofilms of Relevant P. aeruginosa Phenotypes in Cystic Fibrosis Chronic Respiratory Infection: Mucoid and Hypermutable Strains

F1-1992: Activity of the Novel Cephalosporin CXA-101 Tested in Combination with Tazobactam against Cephalosporin-resistant Enterobacteriaceae, P. aeruginosa and B. fragilis

F1-1993: Activity of CXA-101 plus Tazobactam against ESBL-Producing Escherichia coli and Klebsiella pneumoniae

F1-1994: Chequerboard Titrations of Cephalosporin CXA-101 (FR264205) and Tazobactam vs. Beta-lactamase-producing Enterobacteriaceae

F1-1995: FIC Index Determination of CXA-101/Tazobactam in Combination with Amikacin, Aztreonam, Meropenem, Levofloxacin, and Tigecycline against E. coli, K. pneumoniae, and P. aeruginosa Strains.

F1-1996: In Vitro Assessment Using Time-kill Curves of CXA-101 (CXA)/Tazobactam (TAZ) Against Escherichia coli (EC), Klebsiella pneumoniae (KP), and Pseudomonas aeruginosa (PA) Strains

F1-1997: Quality Control Parameters for CXA-101 Broth Microdilution Susceptibility Tests

F1-1998: Disk Diffusion Testing of CXA-101 and CXA-101 in Combination with Tazobactam against Target Pathogens

F1-1999: In Vivo Activity of CXA-101 plus a 2:1, 4:1, or 8:1 Ratio of Tazobactam against Various Enterobacteriaceae Producing Extended-Spectrum Beta-Lactamases in the Thighs of Neutropenic Mice

F1-2000: 50% Effective Dose Determination of CXA-101 Alone or in Combination with Tazobactam for Treating Experimental Peritonitis in Mice Due to ESBL-Producing Escherichia coli strains: Comparison with Ceftazidime and Piperacillin/Tazobactam

F1-2001: Pharmacokinetics Study of CXA-101 (CXA) in Combination with Tazobactam in Dogs after Intravenous Administration

F1-2002: In Vivo Activity of CXA-101, a New Cephalosporin, against Pseudomonas aeruginosa and other Enterobacteriaceae in the Thighs of Neutropenic Mice

F1-2003: CXA-101 Population PK Analysis and Monte Carlo Simulation for PK/PD Target Attainment and Dose Regimen Selection

F1-2004: The Pharmacokinetics and Safety of CXA-101, a New Anti-pseudomonal Cephalosporin, in Healthy Adult Male and Female Subjects Receiving Single- and Multiple-Dose Intravenous Infusions

About Calixa Therapeutics

Calixa Therapeutics, Inc. is a biopharmaceutical company committed to the development and commercialization of novel medicines for the treatment of infectious diseases. The company's initial focus is on developing novel antibiotics for use in the hospital setting. Calixa Therapeutics, which is privately held, is headquartered in San Diego and has operations in the San Francisco Bay Area. For additional information, please visit: www.calixainc.com.

    Contacts:
    Robert Flamm, Ph.D., or David Schull
    Russo Partners
    (212) 845-4226
    robert.flamm@russopartnersllc.com
    david.schull@russopartnersllc.com

    Eckard Weber, M.D.
    Calixa Therapeutics Inc.
    (858) 480-2420
    stone@domainvc.com


'/>"/>
SOURCE Calixa Therapeutics Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Calixa Therapeutics Announces Positive Phase 1 Results for CXA-101, a Novel Intravenous Cephalosporin Antibiotic with Excellent Anti-Pseudomonal Activity
2. Calixa Therapeutics Announces Initiation of Phase 2 Clinical Trial of Its Antibiotic, CXA-101, in Patients with Complicated Urinary Tract Infections
3. Vicus Therapeutics to Present at the 234th American Chemical Society National Meeting in Boston, MA
4. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
5. Amicus Therapeutics Announces Second Quarter 2007 Financial Results
6. TorreyPines Therapeutics Completes Patient Enrollment in Phase IIb Clinical Trial of Tezampanel for the Treatment of Acute Migraine Headache
7. CV Therapeutics Announces Eight Abstracts Accepted for Presentation at the European Society of Cardiology Congress 2007
8. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
9. Protalix BioTherapeutics Treats First Patient in Phase III Clinical Trial of prGCD
10. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
11. TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2017)... 2017  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... that it will be participating in the Deutsche Bank ... Hotel in Boston, Massachusetts on ... 11:20 a.m. Eastern Time. A live webcast ... Investor Relations website at http://investor.zimmerbiomet.com .  The webcast ...
(Date:4/20/2017)... 20, 2017   ZappRx, Inc ., a digital health ... process, today announced it closed $25 million in Series B ... firm based in Seattle that is ... . The Series B round included participation from SR ... and GV (formerly Google Ventures). As part of ...
(Date:4/20/2017)... 2017 Research and Markets has announced ... Services Market Analysis By Service (Manufacturing, Research), By Country, (Brazil, ... 2025" report to their offering. ... The Latin American pharmaceutical contract manufacturing services ... Low drug registration cost in Latin American countries ...
Breaking Medicine Technology:
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... ... (CDC), rising prescription opioid overdose deaths now claim the lives of 62 Americans ... civil case filings against drug manufacturers, distributors, pharmacies and prescribers by more than ...
(Date:4/24/2017)... ... , ... Rod Burkett, CEO of Gardant Management Solutions, was recently featured in ... the forefront of Gardant since it was founded in 1999. His drive and inquisitive ... more than 40 new senior living communities. With his leadership, Gardant has grown to ...
(Date:4/24/2017)... ... 24, 2017 , ... Come to PAINWeekEnd (PWE) Tampa on May 20 and ... educational and exciting 2-day program. , An attendee at a recent PAINWeekEnd said, ... patients” about the course entitled Ain't Misbehavin': Decreasing and Managing Pain Patient Aberrant Behavior, ...
(Date:4/24/2017)... NY (PRWEB) , ... April 24, 2017 , ... ... 72 countries clearly shows that over the last decade, student well-being has seriously ... all the boxes of formal education, join the Islamic State to turn the ...
(Date:4/24/2017)... ... ... “The Saint with Trin, and Omega Station”: a triple feature offering nonstop ... published author, Chris Jackson. Chris Jackson grew up in Abilene, Texas. He ... District teaching English. He is heavily involved in the youth group of his local ...
Breaking Medicine News(10 mins):