Navigation Links
Calithera Biosciences Presents Data for CB-839 in Triple-Negative Breast Cancer Models at the 2013 San Antonio Breast Cancer Symposium
Date:12/12/2013

SOUTH SAN FRANCISCO, Calif., Dec. 12, 2013 /PRNewswire/ -- Calithera Biosciences, a biotechnology company focused on the development of novel cancer therapeutics, today announced the presentation of preclinical data for its lead anti-cancer therapeutic candidate, CB-839, at the 2013 San Antonio Breast Cancer Symposium.  CB-839 is a potent, selective, orally available glutaminase inhibitor that interferes with tumor metabolism and blocks cancer cell growth and survival. 

"Triple-negative breast cancer, which represents 10-20% of all breast cancers, can be aggressive and difficult to treat due to the fact that the current hormonal and HER-2 directed therapies do not work against these tumors.  Recent data indicate that triple-negative tumor growth is driven in part by high glutaminase expression and a reliance on the conversion of glutamine into glutamate to provide fuel for growth.  CB-839 demonstrates potent inhibition of glutaminase and significant anti-tumor activity in triple-negative breast cancer models, both as a single agent and in combination with the standard-of-care drug paclitaxel," said Susan Molineaux, Ph.D., President and Chief Executive Officer of Calithera Biosciences.  "This research also highlights the potential for use of biomarkers to identify patients whose breast cancer is most likely to respond to CB-839 treatment.  We look forward to advancing CB-839 into Phase 1 clinical studies in patients with advanced triple-negative breast cancer and other solid tumors early next year."

The anti-tumor activity of CB-839 was evaluated in a panel of breast tumor cell lines that included both triple-negative breast cancer and hormone receptor-positive subtypes.  Triple-negative breast cancers displayed higher sensitivity to CB-839 treatment, and this sensitivity was correlated with high glutaminase expression relative to tumor cells that were est
'/>"/>

SOURCE Calithera Biosciences
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Calithera Biosciences Secures $35 Million in Series D Financing
2. Pressure BioSciences, Inc. and Target Discovery, Inc. Expand Strategic License Agreement and Collaboration Supporting TDIs Planned Offering of Personalized Medicine Clinical Diagnostic Services
3. Neurocrine Biosciences Announces Conference Call and Webcast to Present First Quarter 2012 Financial Results
4. Amarantus BioSciences to Present at the New York Biotechnology Association (NYBA) 21st Annual Meeting on May 2nd, 2012
5. Neurocrine Biosciences Reports First Quarter 2012 Results
6. Pressure BioSciences, Inc. to Discuss First Quarter 2012 Financial Results And Provide Business Update
7. Ambit Biosciences and Teva Announce Clearance of an Investigational New Drug (IND) Application for CEP-32496, A Novel BRAF(V600E) Inhibitor
8. Neurocrine Biosciences to Present at the Jefferies 2012 Global Healthcare Conference
9. 3-V Biosciences To Present at the Seventh Annual JMP Securities Healthcare Conference
10. Sofie Biosciences receives $1M Phase II SBIR grant from the DOE
11. Frost & Sullivan 2012 New Product Innovation in Bioanalytics Awarded to Protea Biosciences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Research and Markets  has announced the ... report to their offering. ... a hollow needle commonly used with a syringe to ... fluids from it. A hypodermic needle is used for ... cannot be ingested. Hypodermic needles are broadly classified into ...
(Date:7/11/2014)... July 11, 2014  Australian drug delivery company, Phosphagenics ... has raised A$19.3 million via a placement of A$16.3 ... , the U.S., Asia and ... a share purchase plan (SPP) to be offered to ... made in two tranches. "This capital raising ...
(Date:7/11/2014)... New York , July 11, 2014 ... by Transparency Market Research "Endoscopy Devices Market (Endoscopes, Endoscopic ... Size, Share, Growth, Trends and Forecast, 2013-2019" the global ... in 2012 and is expected to grow at a ... an estimated value of USD 36.9 billion in 2019. ...
Breaking Medicine Technology:Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6
... 31, 2011 Restorative Therapies, Inc., advances its new ... injury and paralysis with FDA clearance of the world,s ... system for stepping and standing. FES is ... activity and exercise not otherwise possible for individuals with ...
... Reportlinker.com announces that a new market research ... Global Surgical Incision Closures Industry ... This report analyzes the worldwide markets ... by the following product segments: Stapler Products ...
Cached Medicine Technology:Restorative Therapies, Inc., Today Announced a Rehabilitation Breakthrough, the RT600 Functional Electrical Stimulation (FES) Stepper 2Global Surgical Incision Closures Industry 2Global Surgical Incision Closures Industry 3Global Surgical Incision Closures Industry 4Global Surgical Incision Closures Industry 5Global Surgical Incision Closures Industry 6Global Surgical Incision Closures Industry 7Global Surgical Incision Closures Industry 8Global Surgical Incision Closures Industry 9Global Surgical Incision Closures Industry 10Global Surgical Incision Closures Industry 11Global Surgical Incision Closures Industry 12Global Surgical Incision Closures Industry 13Global Surgical Incision Closures Industry 14Global Surgical Incision Closures Industry 15Global Surgical Incision Closures Industry 16Global Surgical Incision Closures Industry 17Global Surgical Incision Closures Industry 18Global Surgical Incision Closures Industry 19Global Surgical Incision Closures Industry 20Global Surgical Incision Closures Industry 21Global Surgical Incision Closures Industry 22Global Surgical Incision Closures Industry 23Global Surgical Incision Closures Industry 24
(Date:7/14/2014)... A recent study published in the July 2014 issue ... Child and Adolescent Psychiatry confirms the validity of ... for diagnosis of attention-deficit/hyperactivity disorder (ADHD). , In DSM-5, ... 7 in DSM-IV, has been raised to 12. As ... at 12, rather than an earlier age, to reflect ...
(Date:7/14/2014)... years that have passed since acupuncture was first ... used to treat a number of physical, mental ... rehabilitation, headaches, menstrual cramps, asthma, carpal tunnel, fibromyalgia ... Now, a meta-analysis of randomized controlled trials which ... , the journal of The North American Menopause ...
(Date:7/14/2014)... July 14, 2014 Last month Bromell ... their website. The webpage features more detailed information on ... including motorcycles, RVs, ATVs, and boats in the state ... this new feature to the website in order to ... helps encompass the purpose of the website, which is ...
(Date:7/14/2014)... works could lead to the next generation of treatments ... forms when recently evolved genes are damaged, and cells ... , Astrobiologists Dr Charley Lineweaver from The Australian ... University teamed up with oncologist Dr Mark Vincent from ... model. , "The rapid proliferation of cancer cells ...
(Date:7/14/2014)... July 14, 2014 The report ... Services [Physical Security, Life Safety, Facility Management], IT ... Forecast & Analysis (2014 - 2019)” defines and ... an in-depth analysis and forecasting of revenues. The ... various restraints and opportunities impacting it, along with ...
Breaking Medicine News(10 mins):Health News:Bothered by hot flashes? Acupuncture might be the answer 2Health News:New theory turns cancer on its head 2Health News:Intelligent Building Automation Technologies Market Worth $74.8 Billion by 2019 - New Report by MarketsandMarkets 2Health News:Intelligent Building Automation Technologies Market Worth $74.8 Billion by 2019 - New Report by MarketsandMarkets 3Health News:Intelligent Building Automation Technologies Market Worth $74.8 Billion by 2019 - New Report by MarketsandMarkets 4
... Research Inc. (TSX: NRI), a Canadian drug development company ... that are delivered to and through the skin using ... its financial and operational results for the year and ... Key Corporate Developments:, - ...
... radiologists and referring, ... physicians and specialists , ... GE Healthcare,announced today in Asia the release of Centricity PACS Web ... is tightly,integrated to Centricity RIS/ PACS, which bring comprehensive detailed patient,history ...
... Nursing Productivity in the Treatment of Renal Disease , ... ... 2009 -- iSirona®, an innovative provider of data automation solutions ... agreement with NxStage Medical, Inc. (Nasdaq: NXTM), a leading manufacturer ...
... announces the implementation of its rehabilitation software by HealthPoint ... Southeast Missouri Hospital, a 269-bed regional medical complex serving ... functionality for electronically managing therapy documentation, scheduling, referrals, insurance ... ...
... , New web-based research has quantified the attractiveness of ... the features of one woman into 243 variations with ... waist widths. Then more than 34,000 people judged the ... exactly the same in all of the photos, researchers ...
... Modernizes TechnologyWASHINGTON, Feb. 26 President Obama,s first ... (VA) expands eligibility for health care to an ... years, meets the need for continued growth in ... Afghanistan and provides the resources to deliver quality ...
Cached Medicine News:Health News:Nuvo announces 2008 fourth quarter and year-end financial results 2Health News:Nuvo announces 2008 fourth quarter and year-end financial results 3Health News:Nuvo announces 2008 fourth quarter and year-end financial results 4Health News:Nuvo announces 2008 fourth quarter and year-end financial results 5Health News:Nuvo announces 2008 fourth quarter and year-end financial results 6Health News:Nuvo announces 2008 fourth quarter and year-end financial results 7Health News:Nuvo announces 2008 fourth quarter and year-end financial results 8Health News:Nuvo announces 2008 fourth quarter and year-end financial results 9Health News:Nuvo announces 2008 fourth quarter and year-end financial results 10Health News:Nuvo announces 2008 fourth quarter and year-end financial results 11Health News:Nuvo announces 2008 fourth quarter and year-end financial results 12Health News:GE Healthcare Introduces New Web-Based Diagnostic Viewer with Workflow Integration and Streaming Technology for Hospitals in Asia 2Health News:GE Healthcare Introduces New Web-Based Diagnostic Viewer with Workflow Integration and Streaming Technology for Hospitals in Asia 3Health News:iSirona Signs Reference Selling Agreement with NxStage 2Health News:Southeast Missouri Hospital Implements Chart Links Rehabilitation Software for Therapists 2Health News:Southeast Missouri Hospital Implements Chart Links Rehabilitation Software for Therapists 3Health News:Plastic and reconstructive surgery ... in brief 2Health News:President's 2010 Budget Request Strongly Supports VA Programs 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: