Navigation Links
Calithera Biosciences Presents Data for CB-839 in Triple-Negative Breast Cancer Models at the 2013 San Antonio Breast Cancer Symposium
Date:12/12/2013

SOUTH SAN FRANCISCO, Calif., Dec. 12, 2013 /PRNewswire/ -- Calithera Biosciences, a biotechnology company focused on the development of novel cancer therapeutics, today announced the presentation of preclinical data for its lead anti-cancer therapeutic candidate, CB-839, at the 2013 San Antonio Breast Cancer Symposium.  CB-839 is a potent, selective, orally available glutaminase inhibitor that interferes with tumor metabolism and blocks cancer cell growth and survival. 

"Triple-negative breast cancer, which represents 10-20% of all breast cancers, can be aggressive and difficult to treat due to the fact that the current hormonal and HER-2 directed therapies do not work against these tumors.  Recent data indicate that triple-negative tumor growth is driven in part by high glutaminase expression and a reliance on the conversion of glutamine into glutamate to provide fuel for growth.  CB-839 demonstrates potent inhibition of glutaminase and significant anti-tumor activity in triple-negative breast cancer models, both as a single agent and in combination with the standard-of-care drug paclitaxel," said Susan Molineaux, Ph.D., President and Chief Executive Officer of Calithera Biosciences.  "This research also highlights the potential for use of biomarkers to identify patients whose breast cancer is most likely to respond to CB-839 treatment.  We look forward to advancing CB-839 into Phase 1 clinical studies in patients with advanced triple-negative breast cancer and other solid tumors early next year."

The anti-tumor activity of CB-839 was evaluated in a panel of breast tumor cell lines that included both triple-negative breast cancer and hormone receptor-positive subtypes.  Triple-negative breast cancers displayed higher sensitivity to CB-839 treatment, and this sensitivity was correlated with high glutaminase expression relative to tumor cells that were est
'/>"/>

SOURCE Calithera Biosciences
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Calithera Biosciences Secures $35 Million in Series D Financing
2. Pressure BioSciences, Inc. and Target Discovery, Inc. Expand Strategic License Agreement and Collaboration Supporting TDIs Planned Offering of Personalized Medicine Clinical Diagnostic Services
3. Neurocrine Biosciences Announces Conference Call and Webcast to Present First Quarter 2012 Financial Results
4. Amarantus BioSciences to Present at the New York Biotechnology Association (NYBA) 21st Annual Meeting on May 2nd, 2012
5. Neurocrine Biosciences Reports First Quarter 2012 Results
6. Pressure BioSciences, Inc. to Discuss First Quarter 2012 Financial Results And Provide Business Update
7. Ambit Biosciences and Teva Announce Clearance of an Investigational New Drug (IND) Application for CEP-32496, A Novel BRAF(V600E) Inhibitor
8. Neurocrine Biosciences to Present at the Jefferies 2012 Global Healthcare Conference
9. 3-V Biosciences To Present at the Seventh Annual JMP Securities Healthcare Conference
10. Sofie Biosciences receives $1M Phase II SBIR grant from the DOE
11. Frost & Sullivan 2012 New Product Innovation in Bioanalytics Awarded to Protea Biosciences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)...  In the Friday, December 19 edition of ... Information Technology (HIT) features Konica Minolta, the company announced today. The ... several leading healthcare organizations. In addition to the ... such as New York , Chicago ... , Minneapolis and San Francisco ...
(Date:12/19/2014)... 2014 Breckenridge Pharmaceutical, Inc. announced today that ... Laboratories Pvt. Ltd. ( Hyderabad, India ) ... new ANDAs.  Under the terms of the agreement, MSN ... Breckenridge for the U.S. market, and Breckenridge will market ... MSN have agreed to develop an oral antibiotic with ...
(Date:12/19/2014)... and CARDIFF-BY-THE-SEA, Calif. , ... SRNE ;  Sorrento), an oncology company ... and Conkwest, Inc., a privately-held immuno-oncology company developing ... (NK) cell-line based therapy, announced today that the ... jointly develop next generation CAR-TNK™ (pronounced as "Car-Tank") ...
Breaking Medicine Technology:USA Today Supplement Featuring Konica Minolta Focuses on Impact of Healthcare IT 2Breckenridge Pharmaceutical signs Multi-Product Generic Agreement with MSN Laboratories Pvt. Ltd. 2Sorrento and Conkwest Announce Exclusive Global Collaboration 2Sorrento and Conkwest Announce Exclusive Global Collaboration 3Sorrento and Conkwest Announce Exclusive Global Collaboration 4Sorrento and Conkwest Announce Exclusive Global Collaboration 5
... IBM (NYSE: IBM ) and Novartis (NYSE: ... a competition among a number of the world,s ... find new ways to address the rise of non-communicable diseases ... http://photos.prnewswire.com/prnh/20090416/IBMLOGO ) Illnesses such as heart disease, ...
... N.C., Oct. 7, 2011 As bio-pharmaceutical companies lose ... and media scrutiny, the role of internal Advocacy groups ... groups will tackle the emphasis on cost effectiveness of ... that address the value of care. Since ...
Cached Medicine Technology:IBM Launches University Competition to Combat Growth of Non-Communicable Diseases 2IBM Launches University Competition to Combat Growth of Non-Communicable Diseases 3Pharmaceutical Advocacy Groups Focus on Value-of-Care Initiatives 2
(Date:12/22/2014)... NY (PRWEB) December 22, 2014 ... a federal panel of judges has granted a request ... in the U.S. District Court, Eastern District of Louisiana. ... an order on December 12 to transfer over 50 ... 22 districts to the Louisiana court for consolidation under ...
(Date:12/22/2014)... FL (PRWEB) December 22, 2014 Christmas is ... Beauty® has a fast and easy solution that will please: ... cards can be purchased from from $25 up to $350," ... offer 100% customer satisfaction and a wide array of skin ... no fees and no expiration dates. , Gift delivery ...
(Date:12/22/2014)... 22, 2014 The NLN’s ... development programs this month. Faculty have been selected ... nurse educators fast-tracked for administrative leadership roles within ... Program for Simulation Educators, featuring a curriculum uniquely ... nursing education. , Twenty nurse educators were ...
(Date:12/21/2014)... (PRWEB) December 22, 2014 Recently, BambooFlooringChina.com, ... durable strand woven bamboo flooring collection , and launched ... 25%. The promotion is valid until Jan. 30, 2015. ... woven bamboo is the hardest bamboo flooring available today; ... resembling that of traditional teak hardwoods. Strand woven bamboo ...
(Date:12/21/2014)... 21, 2014 When families in Coral Gables ... they call? The new answer is Lice Troopers . ... 33134, their newest treatment center will be the new go-to ... and without the use of harmful chemicals or pesticides. ... January 1, 2015. Like the company’s first clinic (located at ...
Breaking Medicine News(10 mins):Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 2Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 3Health News:Panel Orders Xarelto Lawsuits Consolidated Into Multi-District Litigation Reports Alonso Krangle LLP 4Health News:NLN Leadership Institute Announces 2015 Cohorts 2Health News:NLN Leadership Institute Announces 2015 Cohorts 3Health News:BambooFlooringChina.com Announced Its Durable Strand Woven Bamboo Flooring Collection 2Health News:All-Natural Florida Lice Removal Company Opens New Lice Treatment Salon In South Florida 2
... The influence of genetics increases as young women transition from ... researchers at Washington University School of Medicine in St. Louis ... girls begin to drink, genes play a larger role if ... researchers studied 3,546 female twins ages 18 to 29 to ...
... Groundbreaking Program Addresses the Nursing Shortage By Supporting,1500 ... April 23 The Robert Wood Johnson,Foundation (RWJF) ... announced today the creation of the RWJF New ... nation,s nursing shortage by,dramatically expanding the pipeline of ...
... 23 Florida,s elected leaders,received a message from ... urging Governor Charlie Crist and legislative leaders not ... of the state,s most,vulnerable citizens., Driven by ... by gurney,the petitions ask Governor Crist, Senate President ...
... HEIGHTS, Ill. Lumpectomy or breast conservation surgery is ... performed. A benefit of the surgery is that only ... can be the resulting physical appearance of the breast, ... in Aprils Plastic and Reconstructive Surgery, the official medical ...
... New Business Alliance will help to raise funds ... K2 Logistics, an industry leader,focused on single-source supply ... spirit, K2 Logistics, headquartered in Eagan, announced,today its ... of,Minnesota (PAM) Team. Also joining in the fight ...
... Endocrine Society,s 90th Annual MeetingENDO 08will be held at ... 15-18, 2008. , Reporters can register here: ... all over the world are expected to assemble for ... endocrinology. , It is the opportunity for journalists ...
Cached Medicine News:Health News:Environment key early: Genes' role expands in alcohol dependence 2Health News:Environment key early: Genes' role expands in alcohol dependence 3Health News:Robert Wood Johnson Foundation Partners with AACN to Launch New Careers in Nursing Scholarship Program 2Health News:Robert Wood Johnson Foundation Partners with AACN to Launch New Careers in Nursing Scholarship Program 3Health News:Robert Wood Johnson Foundation Partners with AACN to Launch New Careers in Nursing Scholarship Program 4Health News:Thousands Sign Petitions Urging Governor Crist and Legislative Leaders to Save Healthcare Coverage for 40,000 Floridians 2Health News:Thousands Sign Petitions Urging Governor Crist and Legislative Leaders to Save Healthcare Coverage for 40,000 Floridians 3Health News:Breast reconstruction advances fix distortions left by lumpectomy 2Health News:K2 Logistics & Strategic Warehousing Join The Parkinson Association of Minnesota (PAM) Team! 2Health News:K2 Logistics & Strategic Warehousing Join The Parkinson Association of Minnesota (PAM) Team! 3Health News:ENDO 08: Latest news on hormones, steroids, obesity, diabetes and more 2
The advanced optics of Frequency 55 Aspheric offer an unsurpassed level of visual quality. By focusing light to a common focal point on the back of eye, instead of a general area, the aspheric design...
The proven daily wear spherical soft contact lens....
Surevue brand contact lenses deliver exceptional overall performance in a contact lens since they're easy to use and offer great comfort....
An easy-to-fit high water content spherical soft lens manufactured using cast molding technology, and designed for use in the correction of myopia on a daily wear or extended wear basis....
Medicine Products: