Navigation Links
Caliper Life Sciences Introduces Drug Combination Services to Identify Synergistic Response of Compounds
Date:12/3/2007

- Screening Determines Efficacy and Safety of Combination Drug Therapies -

HOPKINTON, Mass., Dec. 3 /PRNewswire-FirstCall/ -- Caliper Life Sciences, Inc. (Nasdaq: CALP) today launched drug combination services through Caliper Discovery Alliances & Services (CDAS). These new services will help researchers determine the efficacy of combination drug therapies and identify potentially harmful combinations before therapies enter clinical trials. Studies, performed in Caliper's anti-cancer cell proliferation panel, cellular cytokine/chemokine release assays or using in vivo efficacy models, will help identify synergistic responses of drug combinations and eliminate antagonistic mixtures of drugs.

Drug combination studies are increasingly valuable to pre-clinical pharmaceutical research. The simultaneous use of a variety of drugs is common today for the treatment of bacterial infections, HIV, hypertension and cancer. Drug combination testing is subsequently a growing trend in many areas including oncology. If a combination is synergistic, lower doses can be used to achieve the same or better efficacy, which can lead to lower toxicity and safer patient care.

"Drug combination studies using cancer cell lines create a relationship between in vitro screening and profiling, and in vivo animal models. This connection is critical as researchers strive to understand how drug combinations may react in humans," said Kevin Hrusovsky, President and CEO, Caliper Life Sciences. "The exact same cell lines used in the in vitro drug combination testing can be used to create in vivo tumor models to further assess efficacy using the IVIS imaging platform."

The CDAS drug combination studies combine the liquid-handling, automation and imaging elements of Caliper's business. Drug combination studies can show whether chemical entities improve the efficacy of existing standard care treatments, providing a possible catalyst to FDA approval and market adoption. Testing combinations in vitro and in vivo also ensures that new clinical compounds will not decrease the effectiveness of standard therapy, thereby avoiding potentially harmful consequences for human study subjects. Drug combination studies also allow clinicians to better optimize the doses used in clinical trials as well.

About Caliper Life Sciences

Caliper Life Sciences is a premier provider of leading-edge technologies enabling researchers in the life sciences industry to create life-saving and enhancing medicines and diagnostic tests more quickly and efficiently. Caliper is aggressively innovating new technology to bridge the gap between in vitro assays and in vivo results and then translating those results into cures for human disease. Caliper's portfolio of offerings includes state-of-the-art microfluidics, lab automation & liquid handling, optical imaging technologies, and discovery & development outsourcing solutions. For more information please visit http://www.caliperLS.com.


'/>"/>
SOURCE Caliper Life Sciences, Inc.
Copyright©2007 PR Newswire.
All rights reserved

Related medicine technology :

1. ImmuneRegen BioSciences Reports Material Transfer Agreement with VaxGen, Inc.
2. Intellect Neurosciences, Inc. to Present Data on Alzheimers Vaccine at 13th International Congress of Immunology Conference
3. Advanced Life Sciences Collaborates with U.S. Government to Study Cethromycin as Treatment for Anthrax and Other High-Priority Biodefense Agents
4. ImmuneRegen BioSciences, Inc. Demonstrates Radilex(TM) Increases Disease-Fighting White Blood Cells
5. Upstream Biosciences Acquires Innovative Platform Technology and Drug Candidates for Tropical Parasitic Diseases
6. Human Genome Sciences Completes Enrollment of First Phase 3 Albuferon(R) Trial Ahead of Schedule
7. Advanced Life Sciences Announces ALS-357 Granted FDA Orphan Drug Designation for Metastatic Melanoma
8. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
9. Advanced Life Sciences to Present Data on Selected Cethromycin Therapeutic Studies at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy
10. Alfacell Corporation to Present at UBS Global Life Sciences Conference
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)...  Diplomat Pharmacy, Inc. (NYSE: DPLO ) is pleased to announce the promotion of ... Strategies effective Jan. 23, 2016. To learn ... ... ... ...
(Date:2/12/2016)...  SI-BONE, Inc., a medical device company that pioneered the use ... surgical (MIS) device indicated for fusion for certain disorders of the ... Medicare Administrative Contractor (MAC) covering the states of Connecticut ... , Massachusetts , Minnesota , ... , Rhode Island , Vermont ...
(Date:2/12/2016)... SEOUL, South Korea , Feb. ... Macrogen, Inc. today announced they will form a ... for precision medicine in cancer. The goal of ... digital-sorting technology with Macrogen,s high-throughput Next Generation Sequencing ... the Clinical Laboratory Improvement Amendments (CLIA) of 1988 ...
Breaking Medicine Technology:
(Date:2/12/2016)... ... February 12, 2016 , ... The law firm of Morrow, Morrow, Ryan & ... purpose of these scholarships is to encourage applicants to pursue a degree in their ... these two parishes. , “We have available jobs in St. Landry and Evangeline ...
(Date:2/12/2016)... ... 2016 , ... Each year, the American Physical Therapy Association (APTA) offers a ... Anaheim Convention Center. Almost 10,000 physical therapists across the country are expected to attend ... about their chosen field and network with their colleagues. As in years past, ...
(Date:2/12/2016)... ... February 12, 2016 , ... ... today announced the integration of Clarity Intelligence Platform (CIP) into Cielo®, a discovery, ... real-time business intelligence (BI) to their small and medium business (SMB) clients. ...
(Date:2/12/2016)... Colorado (PRWEB) , ... February 12, 2016 , ... Vail ... ASC Industry Physician Leaders to Know in 2016 . The list consists of physicians ... nominated physicians to establish this list. , An Ambulatory Surgery Center, also known ...
(Date:2/12/2016)... ... ... For Coast Dental dentist Everet Lake, DDS, the smiles began at dawn. He ... 7 a.m. to volunteer at Friday’s Dentistry from the Heart event in New Port ... hundreds of uninsured and underinsured people receive much-needed dental care. , This was ...
Breaking Medicine News(10 mins):