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Caliper Continues Participation in EPA's Expanded ToxCast Program; Receives Remaining Phase II Compounds for Screening in Fourth Quarter
Date:12/7/2010

opment.  The EPA recently announced the screening of 1,000 chemicals under the ToxCast program.  

The CDAS assays use human and animal proteins which mediate key biological functions in the body to screen for possible adverse or toxic effects of chemicals. Caliper recently initiated testing of the second half of the 700 chemicals that comprise Phase II of the ToxCast screening program through the CDAS in vitro panel, which includes over 230 such assays.  

Many of the chemicals being tested in the ToxCast program are components of industrial and consumer products, as well as agrichemicals and pharmaceuticals, which were previously tested for in vivo toxicity using live animals.  By comparing the in vitro data being generated by CDAS under the ToxCast program with the known in vivo effects of these ToxCast library compounds, the predictive potential of the in vitro assays can be determined.  The EPA is tasked with testing thousands of compounds and chemicals each year, which has led to a significant backlog in the regulatory approval process.  The goal of the ToxCast program is to reduce the EPA's dependence on expensive and lengthy animal testing and implement solutions that enable faster identification of harmful chemicals at a lower cost and with higher accuracy.

For additional details about the current status of EPA ToxCast program, please visit the EPA news announcement "EPA Screens 1,000 Chemicals Using ToxCast" at http://yosemite.epa.gov/opa/admpress.nsf/d0cf6618525a9efb85257359003fb69d/73ec2518e34bc93d852577eb0060dd7c!OpenDocument.

About Caliper Life Sciences

Caliper Life Sciences is a premier provider of cutting-edge technologies enabling researchers in the life sciences industry to create life-saving and enhancing medicines and diagnostic tests more quick
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