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Caliber and ImmunGene Launch Valor Biotherapeutics, a Joint Venture to Develop Antibody-Interferon Fusion Therapeutics to Treat Cancers
Date:11/13/2012

Valor Biotherapeutics further marks the evolution of Caliber from a technology company into a drug development company with a highly promising pipeline.   We intend to leverage our complementary resources to develop these product candidates and welcome the opportunity to work with the highly accomplished ImmunGene team to accomplish our goals." 

"We are impressed with the promise of ImmunGene's mAb-IFN fusion technology in addressing many unmet needs in cancer," said Mr. Shanahan.  "We are thrilled to support the development of this technology through our joint venture and demonstrate the potential benefits this technology can bring to cancer patients."

"This joint venture will allow us to accelerate the development of ImmunGene's antibody interferon fusion drug candidates into human proof-of-concept studies in cancer patients." said Sanjay D. Khare, Ph.D., CEO of ImmunGene.  "We believe our technology has the potential to improve the treatment of certain cancers and that Caliber's unique experience in cancer research will help us realize the clinical and commercial potential of our pipeline through this promising joint venture." 

About Monoclonal Antibody – Interferon (mAb-IFN) Fusion Proteins

mAb-IFN fusion proteins are a new class of biotherapeutics that are produced by fusing antibodies to tumor cell-killing cytokines (e.g. IFN).  These fusion proteins offer potential advantages because several important properties can be built into a single, genetically engineered molecule.  They are thought to kill tumor cells mainly by stimulating apoptosis, in an ADCC (antibody-dependent cell-mediated cytotoxicity)-independent manner.  Consequently, these molecules have the potential to be efficacious in patients with defective ADCC mechanisms.  In addition, they have the potential to be cytotoxic to tumor cells with low density of targeted surface antigens.  The fusion proteins ret
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