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Caldolor® (ibuprofen) Injection Gaining Approval on Formulary at U.S. Medical Centers
Date:9/23/2010

therapy has demonstrated pain relief above and beyond that which was provided by narcotics alone, while also reducing narcotic use. A recently published clinical trial shows that dosing Caldolor at induction of analgesia and post-operatively is effective in treating pain and reducing morphine use in adult patients. The newly published study entitled "A Multicenter, Randomized, Double-Blind Placebo-Controlled Trial of Intravenous-Ibuprofen (IV-Ibuprofen) for Treatment of Pain in Post-Operative Orthopedic Adult Patients" appeared in the August 2010 edition of the peer-reviewed journal Pain Medicine and concludes that IV ibuprofen significantly decreased pain with movement by 26% (p<0.001) and decreased morphine use by 31% (p<0.001) when compared with placebo. There was no significant difference between placebo and IV ibuprofen in the number of patients with bleeding adverse events, the incidence of blood transfusions or other serious adverse events. More patients receiving IV ibuprofen experienced vomiting and more patients receiving placebo experienced dyspepsia.

The World Health Organization has recommended a multi-modal approach to pain management, with non-opioid analgesics such as ibuprofen recommended as first-line treatment.(1) Caldolor offers IV delivery of ibuprofen to control pain while allowing physicians to limit opioid use. Reduction in opioid use could potentially reduce opioid-related side effects such as sedation, nausea, vomiting, cognitive impairment and respiratory depression.

Dr. Dean Adams, colon and rectal surgeon at St. Elizabeth Healthcare in Greater Cincinnati and owner of Colorectal Care of Northern Kentucky, has also seen a substantial improvement in patients recovering from colorectal surgeries when treated with Caldolor. Rated by HealthGrades as a Distinguished Hospital for Clinical Excellence, St. Elizabeth ranks in the top 5 percent in the nation for quality of care and is one of the oldest, lar
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SOURCE Cumberland Pharmaceuticals Inc.
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