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CalciMedica Announces Issuance of US Patent No. 7,645,588, a Composition Patent Involving STIM1, a Key Component of the CRAC Channel
Date:2/16/2010

new drug (IND) status with our lead molecule, an oral, selective CRAC channel inhibitor with in vivo efficacy in animal models of inflammation, and we look forward to realizing our goal of bringing this first-in-class drug into clinical development."

About CalciMedica, Inc.

CalciMedica is dedicated to the discovery and development of novel small molecule drugs for the treatment of autoimmune and inflammatory diseases. The primary focus of the company's drug discovery effort is based on the specific inhibition of calcium release-activated calcium (CRAC) channels, a key component of the Icrac-NFAT pathway. The Icrac-NFAT calcium entry pathway is essential for the adaptive immune response, and has been clinically validated as an important drug target in humans through the use of calcineurin inhibitors. The CRAC channel is the gatekeeper for this pathway, and based on the phenotype of SCID patients with loss-of-function mutation in Orai1, it is predicted that selective inhibition of CRAC channels should be effective and safe for chronic immunomodulation. CalciMedica has acquired exclusive rights to both STIM1 and Orai1 which act synergistically to regulate CRAC channel activity. CalciMedica has discovered novel potent and selective CRAC channel inhibitors with good in vivo efficacy and pharmaceutical properties and is advancing the lead molecule to an investigational new drug (IND) filing. CalciMedica is located in La Jolla, California. 

SOURCE CalciMedica, Inc.

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