Navigation Links
CalciMedica Announces Issuance of US Patent No. 7,645,588, a Composition Patent Involving STIM1, a Key Component of the CRAC Channel
Date:2/16/2010

LA JOLLA, Calif., Feb. 16 /PRNewswire/ -- CalciMedica today announced that the US Patent and Trademark Office has issued to CalciMedica US Patent No. 7,645,588, a composition patent involving STIM1, a key component of the calcium release-activated calcium (CRAC) channel. The patent, entitled "Composition comprising a cell comprising a STIM1 protein and an agent that modulates intracellular calcium and methods of use," has a priority date of March 4, 2003 and was issued on January 12, 2010. The compositions covered by the patent include both a recombinant cell expressing the STIM1 protein and an agent that reduces calcium ion stores in the cell.

The CRAC channel is the gatekeeper for the Icrac-NFAT pathway, a network essential for the adaptive immune response. STIM1, a calcium sensor in the endoplasmic reticulum, interacts with Orai1, the CRAC channel subunit in the plasma membrane, to regulate calcium entry into T cells. The composition of matter claims can be used for multiple purposes, including assays for the discovery of agents that modulate the activity of CRAC channels. These agents, in turn, can be developed for the treatment of autoimmune diseases, such as rheumatoid arthritis, psoriasis, multiple sclerosis, ulcerative colitis as well as organ transplant rejection and other diseases of the immune system, such as allergy and asthma.

"Establishing patent protection of the STIM1 technology, a key component of our drug discovery platform, is an important achievement for CalciMedica," said Gonul Velicelebi, PhD, Chief Executive Officer of CalciMedica and co-inventor on the patent. "We have made great strides in using this technology to identify novel small molecule CRAC channel inhibitors and validating the potential of the CRAC channel as a therapeutic target. We are advancing to investigational new drug (IND) status with our lead molecule, an oral, selective CRAC channel inhibitor with in vivo efficacy in animal models of inflammation, and we look forward to realizing our goal of bringing this first-in-class drug into clinical development."

About CalciMedica, Inc.

CalciMedica is dedicated to the discovery and development of novel small molecule drugs for the treatment of autoimmune and inflammatory diseases. The primary focus of the company's drug discovery effort is based on the specific inhibition of calcium release-activated calcium (CRAC) channels, a key component of the Icrac-NFAT pathway. The Icrac-NFAT calcium entry pathway is essential for the adaptive immune response, and has been clinically validated as an important drug target in humans through the use of calcineurin inhibitors. The CRAC channel is the gatekeeper for this pathway, and based on the phenotype of SCID patients with loss-of-function mutation in Orai1, it is predicted that selective inhibition of CRAC channels should be effective and safe for chronic immunomodulation. CalciMedica has acquired exclusive rights to both STIM1 and Orai1 which act synergistically to regulate CRAC channel activity. CalciMedica has discovered novel potent and selective CRAC channel inhibitors with good in vivo efficacy and pharmaceutical properties and is advancing the lead molecule to an investigational new drug (IND) filing. CalciMedica is located in La Jolla, California. 

SOURCE CalciMedica, Inc.

RELATED LINKS
http://www.calcimedica.com

'/>"/>

SOURCE CalciMedica, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
3. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
4. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
5. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
6. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
7. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
8. Emisphere Technologies, Inc. Announces 2007 Second Quarter Financial Results
9. Amicus Therapeutics Announces Second Quarter 2007 Financial Results
10. Genta Incorporated Announces Second Quarter 2007 Financial Results and Corporate Highlights
11. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... Feb. 11, 2016  Ampio Pharmaceuticals, Inc. (NYSE MKT: ... entered into a Controlled Equity Offering SM Sales ... Michael Macaluso , Chairman and CEO, stated "During ... are not currently raising money and that we have ... 2017 and still complete all of our current objectives ...
(Date:2/11/2016)... Germany , February 11, 2016 ... up 6.8% to EUR 1,377.2m  Adjusted EBITDA climbs to ... 18.0% to EUR 3.41  Proposed dividend of EUR 0.85 ... sale of glass tubing business and refinancing successfully completed  ... to 5% on organic basis  Adjusted EBITDA expected ...
(Date:2/10/2016)... REDWOOD CITY, Calif., Feb. 10, 2016   Genomic Health, Inc. ... progress for the quarter and year ended December 31, 2015. ... in the fourth quarter of 2015, compared with $69.1 million in ... a constant currency basis, revenue increased 9 percent compared with the ... --> U.S. revenue was $63.9 million in the fourth ...
Breaking Medicine Technology:
(Date:2/11/2016)... ... February 11, 2016 , ... ... the American Academy of Dermatology Annual Meeting at the Walter E. Washington Convention ... raise awareness for both the condition of hyperhidrosis (excessive sweating) and its treatment ...
(Date:2/11/2016)... ... 11, 2016 , ... Husted Kicking has completed its Third Annual ... 6th & 7th, 2016 according to kicking coach Michael Husted. , “This event serves ... NFL’s combine in Indianapolis,” says Husted. “The NFL uses a third party organization to ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... The book, ... for IT services, what questions to ask your IT consultant before signing a contract ... to your computer network. , “With companies relying heavily on e-mail and technology, it’s ...
(Date:2/11/2016)... ... , ... As part of their 2015 end of year funding strategy, ... has gifted $10,000 to University of Chicago to support ovarian cancer research being conducted ... are honored to support a promising young investigator from Dr. Lengyel’s lab at the ...
(Date:2/10/2016)... City, California (PRWEB) , ... February 10, 2016 ... ... Imaging Society (WMIS), known as the World Molecular Imaging Congress (WMIC), will be ... theme for the 2016 meeting is “Imaging Biology…Improving Therapy.” The congress will highlight ...
Breaking Medicine News(10 mins):