CV Therapeutics Announces Archives of Internal Medicine Publication of Study Showing 20 Percent of Heart Attack Patients in Premier Registry Experienced Angina a...( -Study shows angina at one year a...),Health

-Study shows angina at one year associated with significantly higher

incidence of depression-

PALO ALTO, Calif., June 23 /PRNewswire-FirstCall/ -- CV Therapeutics, Inc. (Nasdaq: CVTX) today announced that the Archives of Internal Medicine published results of a major study demonstrating that one in five patients studied experienced chest pain one year after a myocardial infarction (MI), or heart attack, and that this angina was associated with significantly elevated rates of depression among cardiac patients in the registry.

PREMIER (Prospective Registry Evaluating Myocardial Infarction: Events and Recovery) was a "real-world" observational study in nearly 2,500 patients specifically designed to characterize patients' health status one year after a heart attack. Researchers found a significant (p<0.001), consistent association between one year post-MI angina and depression across a wide range of demographic, prior history and treatment variables.

Patients with angina after one year also were more likely to smoke (p<0.001) and undergo revascularization (p<0.001). In addition, the study revealed that 21 percent of the patients with angina in the study suffered daily or weekly angina attacks.

The investigators reported that in patients with angina after one year, 87.9 percent were not taking calcium channel blockers, 30.8 percent were not taking beta blockers and 48.6 percent were not taking nitrates.

"After patients survive a heart attack, a primary goal of treatment is to minimize their angina and optimize their quality of life. The PREMIER study explicitly sought to illuminate the prevalence and predictors of angina after an MI. We found one in five heart attack survivors stil
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