Navigation Links
CSL Behring Study in Animal Models Shows Feasibility of Developing a Half-Life Extended Recombinant FVIIa that Retains Biologic Activity
Date:12/10/2007

In data presented at the ASH 49th annual meeting recombinant factor VIIa-albumin fusion protein seen as first step toward more convenient

treatment option for hemophilia patients with inhibitors

ATLANTA, Dec. 10 /PRNewswire/ -- CSL Behring today announced the results of a pre-clinical study that show for the first time it is feasible to genetically fuse Factor VIIa (FVIIa) to human albumin, prolonging the half- life of this therapeutic protein while retaining its biologic activity. In the study, which was presented at the American Society of Hematology 49th Annual Meeting and Exposition, the half-life of recombinant VIIa-albumin fusion protein (rVIIa-FP) was shown to be extended 6-to-9 fold compared to wild type rFVIIa. Additionally, rVIIa-FP demonstrated a biologic activity comparable to wild type rFVIIa.

Recombinant factor VIIa (rFVIIa) may be used to control bleeding episodes in hemophilia patients with inhibitors. These patients develop an immune response that inhibits the substituted clotting factor from stopping a bleeding episode. However, rFVIIa has a short half-life of approximately 2.5 hours. This necessitates multiple injections, which are inconvenient for both physicians and patients, particularly during surgical intervention.

"A major unmet need in hematology is improving the pharmacokinetic parameters of coagulation factors, such as half-life, while retaining full hemostatic activity," said Dr. Stefan Schulte, Head Pre-clinical R&D, CSL Behring GmbH and lead investigator of the study. "The pharmacological properties of rVIIa-FP seen in our study could one day facilitate a single dosing regimen of one injection per bleeding event, as well as significantly reduce the number of injections hemophilia patients with inhibitors need during surgical interventions."

Recombinant VIIa-FP represents CSL Behring's initial corporate foray into research with recombinant coagulation product technology.

"CSL Behr
'/>"/>

SOURCE CSL Behring
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. CSL Behring Reaches Primary Endpoint in Clinical Study of C1-INH for Treatment of Hereditary Angioedema
2. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
3. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
4. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
5. Allos Therapeutics Initiates Study of PDX in Patients with Cutaneous T-Cell Lymphoma
6. Multiple Myeloma Research Consortium (MMRC) Partners with Novartis to Advance Phase II Study of Deacetylase Inhibitor
7. Potential Safety Issue Identified in Ongoing Phase 2 Clinical Study of HCV-796
8. Study Suggests High-Dose Fish Oil May Significantly Improve Behavior in Children with ADHD
9. MicroDose Announces Positive Results From the QDose Inhaled Insulin Glucose Clamp Study
10. Video: Landmark Study in The Lancet: Patients Treated With Betaseron(R) After First MS Attack Experienced Significant Delay in MS Progression
11. MacroGenics Begins Global Phase 2/3 Protege Study in Recent-onset Type 1 Diabetes Mellitus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)...  United Therapeutics Corporation (NASDAQ: UTHR ) ... District of New Jersey has ... Sandoz, Inc. regarding United Therapeutics, Remodulin ® product.  In ... U.S. Patent No. 6,765,117 is both valid and enforceable ... generic product until the expiration of that patent in ...
(Date:8/29/2014)... 2014 According to the ... Services (Equipment, Reagent, Primer, Probe, Custom Oligos), End-User ... Gene Synthesis, NGS, DNA, RNAi) - Global Forecast ... Synthesis Market is expected to reach $1,712.1 Million ... at a CAGR of 9.8% from 2014 to ...
(Date:8/29/2014)...  Unilife Corporation ("Unilife" or "Company") (NASDAQ: ... to release its financial results for the fiscal 2014 ... market trading ends on Tuesday, September 9, 2014. ... 4:30 p.m. U.S. EDT on Tuesday, September 9, 2014 ... the Company,s financial results, commercial partnerships, and future outlook.  ...
Breaking Medicine Technology:District Court Decision Received In Remodulin Patent Case 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 2Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 3Oligonucleotide Synthesis Market Worth $1,712.1 Million by 2019 4Unilife Corporation to Announce Financial Results for Fiscal Year 2014 Fourth Quarter and Year End on Tuesday, September 9, 2014 2
... March 24, 2011 When it comes to their ... to a January 2011 survey by the American Association ... losing their natural teeth. One way to help people ... During Root Canal Awareness Week, March 27 – April ...
... 2011 An educational symposium at the American Academy of ... learn more about the landscape of chronic opioid therapy. ... Opioid Therapy and Risk Management" and sponsored by Ameritox, will ... The event will be held Saturday, March 26 at 5:30 ...
Cached Medicine Technology:Dispelling Myths of Root Canals Through Education 2Symposium Highlights Evolving Landscape of Chronic Opioid Therapy 2
(Date:8/30/2014)... Saturday 30 August 2014: The first recommendations on ... pulmonary embolism are published today in new ESC ... by Professor Stavros V. Konstantinides (Germany/Greece) and Professor ... on the diagnosis and management of acute pulmonary ... Journal (1) and on the ESC Website. , ...
(Date:8/29/2014)... Colorado (PRWEB) August 29, 2014 Daily Gossip ... popular such program on the market nowadays. This method promises ... power, with the use of some effective alternative sources for ... known alternative energy sources are wind and solar power. ... is currently easily accessible in an eBook. So, this is ...
(Date:8/29/2014)... August 30, 2014 Cancer is ... ones and caretakers. Author Eddie M. Leung knows the suffering ... or bile duct cancer, a very rare and aggressive ... Changed My Life” (published by Xlibris), he shares a glimpse ... he imparts a survivor’s testimony that this disease can be ...
(Date:8/29/2014)... Everyone dreams about looking absolutely great, ... , According to the latest review published by Daily ... imagined with the right tips and recommendations. , ... an amazingly effective and fast method of looking perfectly. ... program is really efficient when it comes to the ...
(Date:8/29/2014)... According to this latest review published by DailyGossop.org, this is ... it is amazingly effective. In fact, the program is commonly ... , Driver Robot is so popular, as it can ... highly effective in finding the right drivers that users need ... writes in its Driver Robot review that what users need ...
Breaking Medicine News(10 mins):Health News:First recommendations on all new oral anticoagulants in pulmonary embolism published 2Health News:Home Made Energy Review Exposes Simple Method to Access Alternative Energy Sources 2Health News:Eddie M. Leung Shares His Testimony As a Survivor of Cancer 2Health News:Eddie M. Leung Shares His Testimony As a Survivor of Cancer 3Health News:Shapeshifter Yoga Review Reveals Kris Fondran's New Body Shaping and Fat Loss Program 2Health News:Driver Robot Review Exposes Popular Hardware Detection Tool 2
... Urology (EAU) and Europa Uomo, the European,advocacy movement ... into an,affiliated partnership as part of their long-term ... with regards to urological diseases. Professor Per-Anders Abrahamsson, ... affiliated partnership, Europa Uomo will gain access to ...
... asked to inhibit their response to a "cocaine-cues" video, ... activity in brain regions linked to drug craving, according ... Energy,s Brookhaven National Laboratory. The results, to be published ... that clinical interventions designed to strengthen these inhibitory responses ...
... , ... Old Eats Octopus," gives mealtime tips for raising children who love to eat everything. ... (PRWEB) November 30, 2009 -- ... as a short-order cook at mealtime? Three new short online videos – one focusing ...
... ... and the body in his new book "Healing Heart to Soul: One Doctor’s Journey of ... ... let go of negative emotions, whether caused by us or inflicted by others, can weigh ...
... , Red Cross offers online giving catalog to help families ... Nov. 30 In spite of the economic downturn, Americans are entering ... percent planning to dig deep into their own wallets to support charities ... of buying them a gift, according to a new survey for the ...
... MINNEAPOLIS, Nov. 30 A new study has found that 27% ... intention to shop for and possibly switch their Medicare coverage. ... past four years, the "intention to switch" measure has been a ... with some intention to switch actually will leave their current insurer ...
Cached Medicine News:Health News:Brain scan study shows cocaine abusers can control cravings 2Health News:Brain scan study shows cocaine abusers can control cravings 3Health News:New Videos Help Parents of Picky Eaters 2Health News:New Videos Help Parents of Picky Eaters 3Health News:Healing from the Inside Out: Compelling New Book Explores the Intricate Connection between Body, Soul, and Better Health 2Health News:American Red Cross Survey Finds 62 Percent of Americans Plan to Donate More Than $25 to Charity This Holiday Season in Spite of Economic Downturn 2Health News:American Red Cross Survey Finds 62 Percent of Americans Plan to Donate More Than $25 to Charity This Holiday Season in Spite of Economic Downturn 3Health News:More Seniors Considering Health Insurance Switch 2
... The Professional Gold Package is ... laboratory. The package includes the ... automated system, starter package accessory ... adapter, specimen mounts 1/2" head, ...
... Semi-Automatic Tissue Sectioning System has maintained the ... system. Researchers from around the globe have ... their fresh and fresh fixed tissue sectioning ... With the Vibratome Automatic Tissue Sectioning Systems, ...
... Plus Sectioning System provides a versatile means ... plant tissues. The 1000 employs a ... freezing or embedding. The creation of ... of enzyme activities, and other deleterious effects ...
... with a square vice mounting device. ... for mounting specimens and placing in ... blocks are annodized black for easy ... They are shipped three to ...
Medicine Products: