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CORDIS Announces Results of Ten-Year CYPHER(R) Sirolimus-Eluting Coronary Stent Follow-Up
Date:8/31/2010

en used in nearly 4 million patients worldwide. Today, with more than 9.000 citations on PubMed, CYPHER(R) Sirolimus-eluting coronary stent is recognized as having the most in depth clinical data, which marked it out as the most effective drug-eluting stent available today with a safety profile presenting minimal risks. CYPHER's(R) body of clinical evidence is completely unmatched by any other drug-eluting stent. The CYPHER(R) stent has consistently proven to control late loss across all vessel sizes and across a broad patient population, even in the most complex types of patients such as patients with diabetes and acute myocardial infarction. In fact, the CYPHER(R) stent has shown more than 70% risk reduction in target lesion revascularization (TLR) when compared with bare metal stents.

About the RAVEL trial

In 2000, patients were enrolled in the RAVEL Trial, the first multi-center, randomized, double-blind, trial in history for drug-eluting stents. The primary objective of RAVEL was the safety and effectiveness of the CYPHER(R) Sirolimus-eluting stent in reducing angiographic in stent late loss (at 6-month follow-up) in de novo native coronary artery lesions as compared to the uncoated BX VELOCITY(TM) balloon-expandable stent. The trial was conducted in 15 centers in Europe and 4 in Latin American and presented by Dr Marie Claude Morice at the Annual Congress of the European Society of Cardiology in Stockholm on 4th September 2001. The results from this trial surpassed expectations, demonstrating virtual elimination of neointimal in-stent proliferation with no measurable late loss (-0.01mm), a binary angiographic restenosis rate of 0%, and no acute or late stent thrombosis.

The above addressed timelines at one view 1999 Cordis initiates the first clinical investigation of a drug-eluting stent. The First-In-Human trial, a safety and feasibility study is conducted in Sao Paolo/Brazil with Dr. Eduardo Sousa, and Rotterdam/The Netherlands with
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SOURCE Cordis Corporation
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