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CMX001 Shows Antiviral Activity in Immunocompromised Transplant Patients With Severe Adenovirus Infection
Date:5/11/2011

rable plasma viremia at baseline, and had viral load data available at > 2 weeks after the first dose of CMX001.  The majority of CMX001 treated patients had a > 99 percent decrease in viral load compared to baseline after two weeks of therapy.  There was a median -2.5 log10 change in viremia from baseline by the last timepoint (range -6.0 to +0.3 log10).  Patients who had either sensitive virus or no proven resistance had a median decrease of almost 1000-fold (-2.9 log10) from baseline.  In patients with pre-existing resistance to CDV, attributable to prior suboptimal cidofovir (CDV) therapy, antiviral activity of CMX001 was a median -0.55 log10 decrease from baseline. Additionally, higher plasma exposure to CMX001 appeared to correlate with a more rapid response.  

These data were presented by Randall Lanier, PhD, Senior Director of Virology, Chimerix, at the 24th Annual International Conference on Antiviral Research in an oral presentation titled “CMX001 (Hexadecyloxypropyl Cidofovir) Antiviral Activity against Adenovirus in Patients Correlates with Drug Levels and Viral Sensitivity” (Abstract # 33).  

About Chimerix

Chimerix is developing novel antiviral therapeutics with the potential to transform patient care in multiple settings, including transplant, oncology, acute care and global health.

The company’s lead candidate, CMX001, is being developed as a potential broad spectrum antiviral agent for the treatment of life-threatening double-stranded DNA (dsDNA) viral diseases. Over 475 people have received CMX001 to date, with a growing body of evidence supporting the drug’s antiviral activity in humans.

Clinical studies of CMX001 include an ongoing Phase 2 study of the prevention/control of cytomegalovirus (CMV) in hematopoietic stem cell transplant patients (CMX001-201), a Phase 2 study being initiated for the treatment of adenovirus (AdV) infection in pe
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SOURCE Chimerix, Inc.
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