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CMX001 Shows Antiviral Activity in Immunocompromised Transplant Patients With Severe Adenovirus Infection
Date:5/11/2011

DURHAM, N.C., May 11, 2011 /PRNewswire/ -- Chimerix, Inc., a pharmaceutical company developing oral antiviral therapeutics, today presented data showing that the majority of immunocompromised patients with severe adenovirus infections who were treated with Chimerix’s lead antiviral compound, CMX001, had a > 99% decrease in viral load compared to baseline after two weeks of therapy.  These CMX001 clinical data, described in an oral presentation today at the 24th Annual International Conference on Antiviral Research (ICAR) held in Sofia, Bulgaria, demonstrate the unique activity of CMX001 against adenovirus (AdV), a life-threatening viral infection without an approved treatment.  

“In the most challenging and urgent of Emergency IND cases, CMX001 has demonstrated antiviral activity against a full spectrum of double-stranded DNA infections including AdV,” said Wendy Painter, MD, Chief Medical Officer for Chimerix. “The results presented in this oral session today further support our efforts to advance CMX001 as a much-needed therapeutic for critically ill transplant patients, including pediatric post-stem cell transplantation patients with life-threatening adenovirus infections.  We also believe that this data will contribute to broader development of CMX001 against the breadth of double-stranded DNA viruses.”  

Chimerix’s CMX001 is in development as a potential broad-spectrum antiviral agent with promising activity against all classes of double-stranded DNA (dsDNA) viruses that can infect humans.  CMX001 is currently in clinical studies against multiple infections including cytomegalovirus and advenovirus, and has the potential to meet a significant unmet medical need for patients at risk of these dsDNA life-threatening viral infections.

The oral presentation provided an analysis of twenty-two patients with adenovirus viremia who had received at least two doses of CMX001, had measu
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SOURCE Chimerix, Inc.
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