Navigation Links
CMU's Bone Tissue Engineering Center Receives Defense Department Research Grant to Help Injured Soldiers

PITTSBURGH, Nov. 4, 2010 /PRNewswire/ -- Carnegie Mellon University's Bone Tissue Engineering Center is working to help soldiers who have lost limbs in combat.



CMU's Jeffrey O. Hollinger, director of the center, and Professor Krzysztof Matyjaszewski have received a three-year, $2.9 million U.S. Department of Defense research grant to develop a therapy that would aid amputees, specifically wounded soldiers. The therapy aims to prevent bone nodules from forming in the muscle at the site of amputation, a painful condition that makes it difficult for amputees to wear limb prostheses.

"This grant will help us prevent heterotopic ossification at the amputation stumps in military troops wounded in combat. Our work is critical as amputations increase with the current surge in Afghanistan," Hollinger said.

Amputations among wounded soldiers increased more than 60 percent, from 47 in 2009 to 77 through Sept. 23 of this year, according to U.S. Army reports. The chief causes of amputations are injuries from improvised explosive devices, or IEDs, that are planted in the ground or along roads.

When a limb is amputated, whether by surgical means or as the result of a violent injury, bone can begin to form in the body's soft tissue through a process called heterotopic ossification. Through the new grant, Hollinger and Matyjaszewski, the J.C. Warner Professor of Natural Sciences at CMU's Mellon College of Science, will develop new tools that will help prevent the growth of these painful bone formations in the muscles of amputees. The bone formations can make it difficult for amputees to wear limb prostheses.

"We are developing novel nano-structured polymers that will place selective biological cues at the stump site to block the bone formation cascade in the soldier's traumatized muscle," said Hollinger, who also is director of the Craniofacial Program, one of five programs funded under the Rutgers-led consortium in the Armed Forces Institute of Regenerative Medicine. Hollinger's program is researching therapies to help heal combat injuries to the face and jaw.

Matyjaszewski, renowned for developing a method that allows for nanoscale control over the polymers formation, said the ability to control and block mineralization and bone formation opens up many compelling opportunities for increased research. Heterotopic ossification can occur in a number of situations other than amputation, most commonly after joint replacement surgery.

The new research grant also will support two research staffers, three full-time Ph.D. students and one post-doctoral fellow.

About Carnegie Mellon University: Carnegie Mellon ( is a private, internationally ranked research university with programs in areas ranging from science, technology and business, to public policy, the humanities and the arts. More than 11,000 students in the university's seven schools and colleges benefit from a small student-to-faculty ratio and an education characterized by its focus on creating and implementing solutions for real problems, interdisciplinary collaboration and innovation. A global university, Carnegie Mellon's main campus in the United States is in Pittsburgh, Pa. It has campuses in California's Silicon Valley and Qatar, and programs in Asia, Australia, Europe and Mexico. The university is in the midst of a $1 billion fundraising campaign, titled "Inspire Innovation: The Campaign for Carnegie Mellon University," which aims to build its endowment, support faculty, students and innovative research, and enhance the physical campus with equipment and facility improvements.

SOURCE Carnegie Mellon University
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. National Stem Cell Holding, Inc. Discovers Non-Embryonic Biomaterials that Promote Tissue Repair
2. BioMosaics Glypican-3 Blood & Tissue Tests Receive CE Marking in Europe
3. CellCyte Genetics Corp. Enters Collaborative Research Agreement With Cleveland Clinic Foundation to Qualify Stem Cell Delivery in Damaged Heart Tissue
4. Study Finds Starion Instruments Tissue Welding Technology Reduces Pain and Bleeding in Tonsillectomy Patients
5. Raydiance Collaborates With Rutgers University and Nations Largest Tissue Bank to Develop Innovative Tissue Processing Approaches
6. Study of Pathwork Diagnostics Tissue of Origin Test Published in the Journal of Molecular Diagnostics: Investigates Test Reproducibility in Multiple Labs to Determine Primary Tumor in Cancer Cases
7. Knee Pain? An Exclusive Study Engineers Cartilage to Match Patients Own Tissue
8. Study Finds Starion Instruments Tissue Welding Technology Safe and Effective in Parotidectomy Procedures
9. Cardium and Tissue Repair Companys Excellarate Candidate for Healing Diabetic Wounds Gains Media Focus in Multiple Regions Across U.S.
10. Phase I/II Study of Targeted Gene Delivery In Vivo - Intravenous Infusions of REXIN-G - Demonstrates Dose-Dependent Anti-Tumor Activity Without Toxicity in Patients With Progressive Chemo-Resistant Bone and Soft Tissue Sarcoma (ASCO 2008)
11. Newly Published Study Shows OPKOs siRNA Bevasiranib Is Taken Up by Target Tissues in the Eye
Post Your Comments:
(Date:11/25/2015)...  The total global healthcare industry is expected to grow ... Latin America has the highest projected growth at ... Japan ), is second with growth projected at 11.5%. ... healthcare expenditure. In 2013-2014, total government funded healthcare was nearly ... to 41.2% in 2013-2014. In real terms, out of pocket ...
(Date:11/25/2015)... Nov. 25, 2015  The American Academy of ... (ACOG), and the March of Dimes cheered today,s ... Our Infants Act of 2015 (S.799), which ... newborns born exposed to drugs, such as opioids, ... introduction, all three organizations have worked together leading ...
(Date:11/25/2015)... Nov. 25, 2015 AAIPharma Services Corp./Cambridge ... of at least $15.8  Million to expand its ... NC . The expansion will provide additional ... the growing demands of the pharmaceutical and biotechnology ... expansion will provide up to 40,000 square feet ...
Breaking Medicine Technology:
(Date:11/27/2015)... ... November 27, 2015 , ... A team of Swiss doctors has ... it. Surviving Mesothelioma has just posted the findings on the website. Click here ... the cases of 136 mesothelioma patients who were treated with chemotherapy followed by EPP ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... Lizzie’s Lice ... The company is offering customers 10% off of their purchase of lice treatment product. ... at full price. According to a company spokesperson. “Finding lice is a sure way ...
(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, ... Table 1-1 ). More than 3.7 billion people under the age of 50 – ... according to WHO's first global estimates of HSV-1 infection . , "The data shocks ...
(Date:11/27/2015)... ... ... A simply groundbreaking television series, "Voices in America", which is hosted by ... of issues that are presently affecting Americans. Dedicated to providing the world with a ... the subjects consumers focus on, one episode at a time. , In the ...
(Date:11/27/2015)... ... November 27, 2015 , ... CBD College is proud to announce ... (CAAHEP) awarded accreditation to its Diagnostic Medical Sonography program. CBD College is honored to ... of twelve colleges and universities in the state of California make the cut. CBD ...
Breaking Medicine News(10 mins):