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CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year

he pathophysiological effects of TNF-alpha. Over the past decade, TNF-alpha has emerged as a major target of basic research and clinical investigation. This cytokine plays a key role in mediating pathological inflammation, and excess TNF-alpha production has been directly implicated in a wide variety of diseases.

UCB filed a BLA with the Food and Drug Administration (FDA) for CIMZIA in the treatment of Crohn's disease on February 28, 2006 and on April 28, 2006 submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMEA) for the same indication. CIMZIA was approved in Switzerland for the treatment of Crohn's disease in September 2007. Preparation for a regulatory submission for CIMZIA in the treatment of RA is ongoing, with filing planned by the end of 2007.


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Guidelines. Guidelines for the Management of Rheumatoid Arthritis 2002

update. Arthritis & Rheumatism, 2002 Vol. 46, No. 2

(2) Sharp JT, Lidsky MD, Collins LC, Moreland J. Methods of scoring the

progression of radiologic changes in rheumatoid arthritis: Correlation

of radiographic, clinical and laboratory abnormalities. Arthritis &

Rheumatism, 1971, Vol. 14, No. 6

(3) Stakeholder Insight: Rheumatoid Arthritis, Biologics battle up the

treatment algorithm, Data Monitor, 7 September 2006

(4) Woolf AD & Pfleger B, Burden of major musculoskeletal conditions:

Bulletin of the World Health Organization 2003, 81 (9)

(5) Panayi G What is RA? National Rheumatoid Arthritis Society, June 2006

(6) Hellier, J et al, HLA-DRB1 genes and patients with late onset

rheumatoid arthritis, Annals of Rheumatic Disease, 2001;60:531-533

(7) Firestein G, Rheumatoid Arthritis, ACP Medicine WebMD Publishing,

August 2004

About UCB

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