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CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year
Date:11/7/2007

* 57.6*

ACR 50 3.1 32.5* 33.1*

ACR 70 0.8 15.9** 10.6+

*p<0.001 **p=0.002 +p=0.008

Six month mean mTSS changes from baseline for RAPID 2

CIMZIA(R) CIMZIA(R)

(certolizumab (certolizumab

pegol) pegol)

Placebo & MTX 200mg & MTX 400mg & MTX

Six months 1.2 0.2** -0.4*

*p<0.001 **p=0.003

(a) ACR (American College of Rheumatology) response scores measure

improvement in the tender and swollen joint count and also include

assessment of the following five parameters: patient's global

assessment, physician's global assessment, patient's assessment of

pain, degree of disability, and level of acute-phase reactant. ACR20

is achieved when there is 20% improvement in the tender and swollen

joint count as well as a 20% improvement in at least three of the five

parameters. ACR50 & ACR70 are an extension of these criteria

corresponding to a 50% and 70% improvement respectively.(1)

(b) Modified Total Sharp Scores (mTSS) is a measurement used to assess

changes in bone erosion and joint-space narrowing measured by X-ray. A

smaller change in mTSS reflects less progression of joint damage.(2)

About Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a progressive autoimmune disease that causes chronic inflammation of the joints. It is estimated that five million people suffer from RA globally,(3) with 0.3 percent to 1 percent of the population in industrialized countries suffering from RA.(4)

Prevalence is not split evenly between genders, since women are three times m
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SOURCE UCB
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