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CIMZIA(R) (certolizumab pegol), Significantly Reduces Structural Damage and Rheumatoid Arthritis Signs & Symptoms for Up to One Year
Date:11/7/2007

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Mareike Mohr, Investor Relations

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Notes to Editors:

RAPID Clinical Trials Program

The RAPID series of clinical trials were designed to establish the efficacy and tolerability of CIMZIA(R) (certolizumab pegol) in the treatment of rheumatoid arthritis. The RAPID clinical trial program is comprised of two large, international, multi-center placebo-controlled studies - RAPID 1 (027) and RAPID 2 (050).

In the year-long RAPID 1 trial, 982 patients were randomly allocated to receive one of three treatment regimens:

-- 393 patients received 400 mg formulation CIMZIA at the start of the

study and at weeks two and four, then 200 mg given every two weeks,

together with methotrexate;

-- 390 patients received 400 mg formulation CIMZIA every two weeks,

together with methotrexate;

-- 199 patients received placebo every two weeks, together with

methotrexate.

In all three arms of the study, the dose of methotrexate was 10 mg per week or greater. Co-primary endpoints for the study RAPID 1 were the ACR20 responder rate(a) at week 24 and the change from baseline in mTSS(b) at week 52.

Six and 12 month ACR responses for RAPID 1

CIMZIA(R) CIMZIA(R)

(certolizumab (certolizumab

pegol) pegol)

Placebo & MTX 200mg & MTX 400mg & MTX

Six months

ACR 20 13.6 58.8 60.8*

ACR 50 7.6 37.1* 39.9*

ACR 70 3.0 21.4* 20.6*

12 months

ACR 20 13.1 53.1* 54.9*

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SOURCE UCB
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