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Most common adverse reactions in the trial in AA patients Grade 3/4 and overall, respectively were: nausea 10%, 53%; vomiting 6%, 42%; headache 6%, 41%; fatigue 4%, 34%; constipation 1%, 33%; convulsions 5%, 23%; with the following important adverse events also reported: hemiparesis 6%, 18%; asthenia 6%, 13%;

Adverse hematologic effects (Grade 3 to 4) in the AA trial in adults were lymphopenia (55%); platelets (19%); neutrophils (14%) and hemoglobin (4%).

7% and 9.5% of patients over age 70 experienced Grade 4 neutropenia or thrombocytopenia in the first cycle, respectively. For patients less than or equal to age 70, 7% and 5.5% experienced Grade 4 neutropenia or thrombocytopenia in the first cycle, respectively.

Full prescribing information for TEMODAR can be found at http://www.spfiles.com/pitemodar.pdf

About Schering-Plough

Schering-Plough is an innovation-driven, science-centered global health care company. Through its own biopharmaceutical research and collaborations with partners, Schering-Plough creates therapies that help save and improve lives around the world. The company applies its research-and-development platform to human prescription, animal health and consumer health care products. Schering-Plough's vision is to "Earn Trust, Every Day" with the doctors, patients, customers and other stakeholders served by its colleagues around the world. The company is based in Kenilworth, N.J., and its Web site is www.schering-plough.com.

SCHERING-PLOUGH DISCLOSURE NOTICE: The information in this press release includes certain "forward-looking statements" within the meaning of the Securities Litigation Refo
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