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CEO Dr. Joseph Kim to Discuss Inovio's Innovative Approach to Treating Cervical Cancer in an Expert Panel
Date:12/11/2013

ers, has completed enrollment of a phase II trial for late stage cervical dysplasia (CIN 2/3), with efficacy data to be reported mid-year 2014. Inovio plans to enter human phase I/IIa trials next year for HPV-caused cervical and head & neck cancers, the latter the most rapidly growing cancer in men. VGX-3100 is designed to raise immune responses against the E6 and E7 oncogenes associated with HPV types 16 and 18. These oncogenes are responsible for transforming HPV-infected cells into pre-cancerous and cancerous cells. The goal is to stimulate a T-cell immune response strong enough to cause the rejection of these infected or transformed cells from the body. VGX-3100 was recognized as the most promising research at the 2011 Global Vaccine Congress, winning first prize in the Edward Jenner Award Competition; it was also recognized by the Vaccine Industry Excellence Awards for "Best Therapeutic Vaccine" in 2013. Best-in-class T cell data from our phase I study was highlighted in a paper published in Science Translational Medicine.

About Inovio Pharmaceuticals, Inc.

Inovio is revolutionizing vaccines to prevent and treat today's cancers and challenging infectious diseases. Its SynCon® vaccines, in combination with its proprietary electroporation delivery, are generating best-in-class immune responses, with therapeutic T-cell responses exceeding other technologies in terms of magnitude, breadth, and response rate. Human data to date have shown a favorable safety profile. Inovio's lead vaccine, a therapeutic against HPV-caused pre-cancers and cancers, is in phase II. Other phase I and preclinical programs target prostate, breast, and lung cancers as well as HIV, influenza, malaria and hepatitis. Partners and collaborators include Roche, the University of Pennsylvania, Merck, NIH, HIV Vaccines Trial Network, National Cancer Institute,
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SOURCE Inovio Pharmaceuticals, Inc.
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