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CEL-SCI Enters Agreement With National Institutes of Health Clinical Center To Determine the Molecular Basis of Multikine Anti-Tumor Effect
Date:10/7/2008

VIENNA, Va., Oct. 7 /PRNewswire-FirstCall/ -- CEL-SCI Corporation (NYSE: CVM) announced today that it has entered into a Material Transfer Agreement (MTA) with the National Institutes of Health Clinical Center (NIHCC) and the laboratory of Dr. Francesco M. Marincola, M.D., to investigate the molecular basis of changes to the tumor microenvironment caused by CEL-SCI's cancer drug Multikine. Dr. Marincola is the Chief of the Infectious Disease and Immunogentics Section, Department of Transfusion Medicine Clinical Center, National Institutes of Health, a leading national and international medical research laboratory.

Pursuant to the agreement, CEL-SCI will provide tumor samples of Multikine treated and untreated matched control patients to the NIHCC, which will then use the latest molecular genomic microarray technology developed by Dr. Marincola's laboratory to look for molecular genomic differences in the tumor microenvironment in patients with squamous cell carcinoma of the head and neck. Should these pre-clinical experiments find significant differences between the Multikine treated and untreated patients, a formal collaboration between CEL-SCI and the NIHCC may be developed in order to expand the study to include patients from CEL-SCI's Pivotal global Phase III clinical trial.

"Multikine's potential to change the tumor microenvironment and, in doing so, break tumor tolerance has been a long-time goal of anti-cancer immunotherapy. We are very excited to be working with Dr. Marincola and the NIH Clinical Center to determine the molecular basis of Multikine's ability to cause tumor microenvironment changes," said Dr. Talor, Senior VP of Research and Manufacturing at CEL-SCI and the developer of Multikine.

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