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CEL-SCI Corporation Releases Letter to Shareholders
Date:2/17/2010

as well as matched tumor samples from head and neck cancer patients not treated with Multikine. The pathologists who participated in this study were blinded to the study and to the patients' clinical outcome.  The results were so impressive that we were able to present the pathology tumor data at ASCO (American Society of Clinical Oncology) and have them published in the very prestigious peer-reviewed Journal of Clinical Oncology.  The promising overall survival data were presented in an oral presentation at the International Conference of Oral Oncology, Amsterdam, 2007 and were published in the peer-reviewed Journal of Oral Oncology.  

The pathology data showed clear clinical benefit to the Multikine-treated patients and suggested that overall patient survival should be improved with Multikine administration.  The longer-term follow-up of the Multikine-treated patients showed that overall survival indeed was improved in these patients.  To avoid any bias, the Multikine survival data in the Phase II trial was compared to the results of all peer reviewed published data available at that time (39 publications).  As time progressed and more publications became available, we updated this comparison and included all of the more recently published peer-reviewed data from these publications (a total of 55 publications).  Our findings of the impact of Multikine administration on the overall survival benefit for these patients still held true.

The safety and efficacy data for Multikine were reviewed by different regulatory agencies, including the US Food and Drug Administration (FDA), prior to giving CEL-SCI clearance to proceed with a global Phase III for Multikine in head and neck cancer.  The open-label, randomized, controlled Phase III study of Multikine in patients with head and neck cancer is designed to demonstrate that Multikine administration to these patients yields
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Related medicine technology :

1. CEL-SCI Secures Manufacturing Facility for Multikine Cancer Drug
2. CEL-SCI Corporation Releases Letter to Shareholders
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5. CEL-SCI CEO to Present at the International Society for Pharmaceutical Engineering 2007 Chesapeake BioShowcase
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