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CEL-SCI Corporation Releases Letter to Shareholders
Date:10/5/2009

he surface of the cell. Different influenza viruses bind to variations of these sialic acids. These sialic acids can be different in different parts of the lung and so some influenza viruses infect the upper respiratory tract, like H1N1, whereas others, like avian flu H5N1, infect cells in the lower lung. Avian flu also likes the warmer environment that is deeper in the lung. While avian flu has high mortality, it is not easily transmitted because it requires special receptors present on a cell to enter the cell and those receptors are only present in cells deep down in the lungs. Therefore large amounts of virus are required to infect a patient with avian flu H5N1. Swine flu, H1N1, on the other hand, is easily transmitted because it prefers other receptors to enter a cell and infects the upper respiratory tract.

After infection, the infected cell becomes a factory to make more viruses. Ultimately, when the virus reproduces in the cell, the cell will die. Before the cell dies, it sends out a molecular warning to other cells, a cytokine protein called interferon. Interferon is an early warning system that puts other cells on the alert to go on strike and not become a virus factory and also warns the body to activate immune protections. The immune protections cause the flu like symptoms that go with influenza disease.

As the infection progresses and spreads, white blood cells called dendritic cells that are in the lung detect the virus, become stimulated and release other cytokines to activate the body's defenses. These cytokines include tumor necrosis factor alpha, interleukin 1 and interleukin 6. These cytokines promote inflammation. Influenza is a very good inducer of these cytokines. The dendritic cells also activate another white blood cell called a T lymphocyte, or T cell. The T cell makes even more cytokines that activate protections, including the production of antibodies by another type of lymphocyte, called
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4. CEL-SCI Posts New Corporate Presentation to Website
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