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VIENNA, Va., Oct. 5 /PRNewswire-FirstCall/ -- The following letter is being released by CEL-SCI Corporation (NYSE AMEX: CVM) to its shareholders:
Dear Fellow Shareholders:
After FDA had communicated several weeks ago that we could proceed with our initial clinical trial with our proposed H1N1 treatment for hospitalized H1N1 patients, we have received many questions with regards to H1N1. With this in mind, we have asked one of our outside collaborators, Ken S. Rosenthal, Ph.D., Professor, Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities Colleges of Medicine and Pharmacology, to help explain in layman's terms the course of the H1N1 disease and why it can be so dangerous. Dr. Rosenthal also has provided an explanation of how CEL-SCI's investigational H1N1 treatment may help in very sick hospitalized patients. Dr. Rosenthal explains:
Background information on influenza and H1N1 influenza:
Influenza infection could have very mild consequences or cause very severe disease. At the least, it may seem like a severe cold and at the worst, it can be life-threatening. Influenza is a respiratory virus spread in the tiny water droplets that we release every time we exhale and then are inhaled by another person. These droplets enter the mouth and nose and travel down the throat and into the lungs. When influenza infects a person's lungs, there are three destructive components working together to cause disease: the virus's ability to kill the lung cells; the immune system's inflammatory reactions that kill influenza infected cells; and bacterial infections that establish themselves in the diseased environment.
Influenza virus infects the ciliated epithelial cells of the respiratory tract that help keep foreign material out of the lungs. The virus attaches to these cells through specific sugar molecules, called sialic acids, on the proteins and lipids on t
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