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CEL-SCI Corporation Releases Letter to Shareholders
Date:9/10/2007

ts (antigens) on the cancer cell.

2) It directly kills cancer cells.

3) It signals the immune system to mount an effective and sustainable

anti-tumor immune response by changing the type of cells that

infiltrate and attack the tumor from the 'usual' CD-8 cells to the

CD-4 cells. This is important because:

-- The tumor is able to shut down the infiltrating CD-8 cells,

but is unable to shut down the CD-4 cell attack, and

-- CD-4 cells help break 'tumor tolerance', thereby allowing

the immune system to recognize, attack, and destroy the

tumor. (The normal immune system is 'blind' to tumor cells

because the tumor cells are derived from the body's own

cells, and thus the body 'thinks' of the tumor as 'self', a

phenomenon also known as 'tumor tolerance'.)

4) Multikine has been shown to render the remaining cancer cells much

more susceptible to radiation and chemotherapy treatment, thereby

making these treatments more effective.

Our U.S. and Canadian cleared Phase III clinical trial is designed to prove that Multikine is effective in the treatment of advanced primary head and neck cancer patients. This disease is being developed as Multikine's first indication because it is a fatal disease with an unmet medical need. Over the past 50 years there has been very little improvement in the survival of these patients (about 50% after 3 years).

However, because Multikine simulates a healthy immune response, it is also expected to be effective in treating many other tumors. Multikine will be developed for use in treating breast cancer, skin cancer and cervical cancer. Studies will also be conducted to confirm observations made during Phase II clinical studies that Multikine has the ability to increase the effectiveness of radiation and chemotherapy. This may someday lead to an ability to reduce the amounts of
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SOURCE CEL-SCI Corporation
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