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CASTLE Study Showed Similar Efficacy Between Once-Daily REYATAZ(R) (atazanavir sulfate)/ritonavir and Twice-Daily lopinavir/ritonavir at 48 Weeks in Previously Untreated HIV-Infected Adult Patients
Date:2/6/2008

t of normal) were similar between treatment arms.

-- Grade 3-4 ALT elevations: 2% in the once-daily REYATAZ(R)

(atazanavir sulfate)/r arm vs. 1% in the twice-daily lopinavir/r arm

-- Grade 3-4 AST elevations: 2% in the REYATAZ/r arm vs. less than 1%

in the lopinavir/r arm

A prespecified descriptive analysis of virologic response rates (HIV-1 RNA less than 50 copies/mL) by baseline CD4+ categories (greater than 200 cells/mm3, between 100 and 200 cells/mm3, between 50 and 100 cells/mm3, and less than 50 cells/mm3) indicated that response rates were consistent across all baseline CD4+ categories in the REYATAZ/r arm. This descriptive analysis indicated that response rates were reduced for subjects with lower CD4+ counts in the lopinavir/r arm. A post hoc analysis showed no association between virologic response rates and CD4+ category within the REYATAZ/r arm (p = 0.51) and a statistically significant association between virologic response rates and CD4+ category within the lopinavir/r arm (p = 0.0085).

About REYATAZ(R) (atazanavir sulfate)

REYATAZ(R) (atazanavir sulfate) is a protease inhibitor that has been studied extensively in both treatment-naive and treatment-experienced HIV- infected patients and is administered once-daily in all patient populations.

Indication and Important Safety Information About REYATAZ(R) (atazanavir sulfate) Capsules

REYATAZ(R) (atazanavir sulfate) is a prescription medicine used in combination with other medicines to treat people who are infected with the human immunodeficiency virus (HIV). REYATAZ has been studied in 48-week trials in both patients who have taken or have never taken anti-HIV medicines.

REYATAZ does not cure HIV or help prevent passing HIV to others.

REYATAZ(R) (atazanavir sulfate) should not be taken with the following medicines: ergot medicines, Versed(R) (midazolam), Halcion(R) (triazolam), Orap(R) (pimozide), Propulsid(R) (cisa
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SOURCE Bristol-Myers Squibb Company
Copyright©2008 PR Newswire.
All rights reserved

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