Navigation Links
CASTLE Study Showed Similar Efficacy Between Once-Daily REYATAZ(R) (atazanavir sulfate)/ritonavir and Twice-Daily lopinavir/ritonavir at 48 Weeks in Previously Untreated HIV-Infected Adult Patients
Date:2/6/2008

ith regard to efficacy, lipid effects, safety and tolerability. Additional study results include:

Achievement of Undetectable Viral Load in Patients with High Baseline Viral Load
* In the study, 74 percent of the 223 patients with high baseline viral

load (greater than or equal to 100,000 copies/mL) in the once-daily

REYATAZ(R) (atazanavir sulfate)/r arm achieved undetectable viral load

at 48 weeks, vs. 72 percent of the 225 patients with high baseline

viral load in the twice-daily lopinavir/r arm.

Immunologic Response

* The mean increase in CD4+ count from baseline at 48 weeks was

203 cells/mm3 in patients in the REYATAZ/r arm and 219 cells/mm3 in

patients in the lopinavir/r arm.

Lipid Effects

* Seven percent of patients in the REYATAZ/r arm vs. eighteen percent of

patients in the lopinavir/r arm had total cholesterol greater than or

equal to 240 mg/dL.

* Less than one percent of patients in the REYATAZ/r arm vs. four percent

of patients in the lopinavir/r arm had triglyceride levels greater than

or equal to 751 mg/dL.

Safety and Tolerability

* 26% of patients in the REYATAZ/r arm and 30% of patients in the

lopinavir/r arm experienced any grade 2-4 treatment-related adverse

event.

* The incidence of treatment discontinuation due to adverse events was

two percent in the REYATAZ/r arm and three percent in the lopinavir/r

arm.

* Renal adverse events of any grade were experienced in two percent of

patients in both treatment arms.

* 34% of patients in the once-daily REYATAZ/r arm and less than 1% of

patients in the twice-daily lopinavir/r arm experienced elevations in

total bilirubin greater than 2.5 times the upper limit of normal.

* The rates of grade 3-4 liver enzyme elevations (greater than 5 times

the upper limi
'/>"/>

SOURCE Bristol-Myers Squibb Company
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Joslin Study Identifies Key Factor That Links Metabolic Syndrome; Finding May Help Millions at High Risk of Cardiovascular Disease
2. Ceremeds OSTENE(R) Stops Bone Bleeding Without Added Risk of Surgical Infection, New Study Finds
3. IDM Pharma Announces Phase 3 Mifamurtide (L-MTP-PE) Study Demonstrating Improved Survival Published in the Journal of Clinical Oncology
4. Tigris Pharmaceuticals Initiates Phase I Study of AFP-464 in Patients with Solid Tumors
5. Inverseon Announces Positive Phase IIa Asthma Study
6. Takeda Doses First Patient in a U.S. Phase 1 Study of Hematide(TM) to Treat Chemotherapy Induced Anemia
7. Study Says Allergy Shots Help Children, Reduce Health Care Costs
8. EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers
9. Mayo Clinic Study Finds Further Association Between Diabetes and Pancreatic Cancer
10. Divine Corporations Personal Lubricants Shown to Block Cancer-causing Viruses in a Study by the National Cancer Institute
11. Protalix BioTherapeutics Extends Research Agreement With Yissum Based on Promising Acetylcholinesterase Program Results in Animal Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... CHICAGO , July 31, 2015 ... Pipeline Review, 2015 market research report that provides ... pipeline stage using data sourced from in-house databases, ... on syringes and needles market products pipeline spread ... organizations supported with 73 tables and 5 figures ...
(Date:7/31/2015)... , July 31, 2015 Quietly, ... of experience, the domestic pharmaceutical industry is strong, with ... products to high international standards. One place ... is in sub-Saharan Africa: Morocco has quietly become the ... South Africa . Indeed, Moroccan pharma companies ...
(Date:7/31/2015)... CHICAGO , July 31, 2015 ... Composition Analyzers Market by Product (Bioimpedance Analyzers (BIA), Dual-Energy ... and Hydrostatic Weighing) - Global Analysis & Forecast to ... Market was pegged at $911.1 Million 2014 and is ... at a CAGR of 9.4% from 2014 to 2019. ...
Breaking Medicine Technology:Syringes and Needles Market Products Pipeline Review 2015 Report 2Syringes and Needles Market Products Pipeline Review 2015 Report 3Syringes and Needles Market Products Pipeline Review 2015 Report 4Syringes and Needles Market Products Pipeline Review 2015 Report 5PharmaBoardroom Releases New Morocco Pharmaceuticals Report 2PharmaBoardroom Releases New Morocco Pharmaceuticals Report 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4
... CV Therapeutics, Inc.,(Nasdaq: CVTX ) announced today ... Cardiology 57th Annual Scientific Session in Chicago,showed that ... isolated from animals and humans., The Company ... ranolazine may,contribute to the statistically significant reductions in ...
... PAREXEL International,Corporation (Nasdaq: PRXL ), a ... Company had completed the expansion of,three Clinical Pharmacology ... States; London, United Kingdom; and Berlin, Germany in ... in the early,phases of clinical development., "Continued ...
Cached Medicine Technology:New Data Shows Ranexa(R) Increases Glucose-Stimulated Insulin Secretion 2New Data Shows Ranexa(R) Increases Glucose-Stimulated Insulin Secretion 3PAREXEL Expands Global Clinical Pharmacology Capabilities 2PAREXEL Expands Global Clinical Pharmacology Capabilities 3PAREXEL Expands Global Clinical Pharmacology Capabilities 4PAREXEL Expands Global Clinical Pharmacology Capabilities 5
(Date:8/1/2015)... ... August 01, 2015 , ... BeverlyD, owner and founder of BeverlyD Luxe ... the very first small business donation to kick off the campaign for healing and ... Her legacy includes a complete line of raw, organic hair care products, as well ...
(Date:7/31/2015)... ... 2015 , ... Ticket Down is a reputable source of authentic tickets for the 2015 ... Fans of every genre of music will have an act they are excited to see ... festival, the following artists will perform: Sam Smith, Coldplay, Kenny Chesney, The Who, Jason ...
(Date:7/31/2015)... ... ... Ticket Down is a reliable source for authentic tickets for the 2015 ... festival will end on Sunday, August 2nd. , Music fans have traveled ... unique and unbelievably popular festival attracts the best in entertainment from around the world. ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... The 2nd ... Church Park in Downtown Memphis on October 3, 2015. The Ride to Fight On ... on cancer research between Methodist Healthcare, The West Clinic and The University of Tennessee ...
(Date:7/31/2015)... ... July 31, 2015 , ... ... Insurance Group, Inc. has re-branded their social media profiles to better connect with ... for consumers to communicate, find information, share insights and opinions. The Rally Insurance ...
Breaking Medicine News(10 mins):Health News:March4thforWellBeing Foundation Kickoff 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:Cheap 2015 Lollapalooza Tickets: Ticket Down Slashes Ticket Prices on Lollapalooza Tickets at Grant Park in Chicago for Saturday, August 1st and Sunday, August 2nd 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 2Health News:West Cancer Center Announces 2nd Annual Ride to Fight On 3Health News:Rally Insurance Group, Inc. Connects to Customers Through Re-branded Social Media Profiles 2
... risk in teens, study suggests , TUESDAY, Dec. 15 ... increases the risk of obstructive sleep apnea, but the ... children, Australian researchers have found. , In sleep tests ... who were referred for evaluation of snoring and possible ...
... RPS Worldwide ... income... known as one of the simplest and easiest business opportunities in America today. ... Orlando, FL (PRWEB) December 15, ... cheer and good will that is going to stick around long after the season,s end. ...
... examines potential for injury when doctors decide benefits of ... News) -- MRI scans can pose a serious risk ... Food and Drug Administration researchers exposed pacemakers to a ... voltage produced at the tip of the pacemaker lead, ...
... nearly as accurate a surgical method, with fewer complications, ... When it comes to diagnosing breast cancer, women and ... that the less invasive "core needle biopsy" procedure is ... open surgical procedure is, with fewer complications than the ...
... , , NEW YORK, ... market research report is available in its catalogue: ... the U.S. and its International Trade [Q4 2009 ... newly published In-Vitro Diagnostic Substance Manufacturing Industry report ...
... ... R.I., Dec. 15 Mergers and acquisitions are commonplace today. As competitors ... they also must face integration challenges, including the integration of safety programs. ... Practices in a Hearing Conservation Program: US Airways ," details how the ...
Cached Medicine News:Health News:Puberty May Trigger Sleep Apnea in Overweight Kids 2Health News:RPS Worldwide Launches Affiliate Program -- The Collection Agency That Gives Christmas Back, Rather Than Take it Away 2Health News:RPS Worldwide Launches Affiliate Program -- The Collection Agency That Gives Christmas Back, Rather Than Take it Away 3Health News:Patients With Pacemakers Should Avoid MRI Scans 2Health News:Needle Biopsy Works Well in Diagnosing Breast Cancer 2Health News:Reportlinker Adds In-Vitro Diagnostic Substance Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 2Health News:Reportlinker Adds In-Vitro Diagnostic Substance Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 3Health News:Reportlinker Adds In-Vitro Diagnostic Substance Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 4Health News:Reportlinker Adds In-Vitro Diagnostic Substance Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 5Health News:Reportlinker Adds In-Vitro Diagnostic Substance Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 6Health News:Reportlinker Adds In-Vitro Diagnostic Substance Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 7Health News:Reportlinker Adds In-Vitro Diagnostic Substance Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 8Health News:New White Paper Details Best Practices of an Occupational Hearing Conservation Program: US Airways 2Health News:New White Paper Details Best Practices of an Occupational Hearing Conservation Program: US Airways 3Health News:New White Paper Details Best Practices of an Occupational Hearing Conservation Program: US Airways 4
... provides safe, effective, current, and ... a quickly accessible format. The ... the latest drugs approved by ... implications are highlighted throughout. This ...
Focuses primarily on the drugs used for treatment and symptom management for colorectal cancer....
Alphabetically organized monographs on more than 1,000 generic and 3,000 trade name drugs....
A handy quick-reference tool for busy residents and clinicians with key facts and points essential for day-to-day patient care....
Medicine Products: