Bronchitol Cystic Fibrosis Dose Trial Result... (more baseline FEV1 of between 40% ...)

HOME >> MEDICINE >> TECHNOLOGY

Bronchitol Cystic Fibrosis Dose Trial Results Positive

Date:8/11/2008

more, baseline FEV1 of between 40%

and 80% of the predicted normal value or a

decline in FEV1 of 20% or more in the last 12

months for those >80% predicted

Study population Median age: 16 yrs, mean FEV1: 63% predicted

Trial Location Canada and Argentina

Commercial partners None

Primary end points:

Change in FEV1 8.6% increase (139 mls) on 400 mg Bronchitol.

-1.6% on 40 mg (p=0.0006). 4.6% on 240 mg,

3.7% on 120 mg

Change in FVC 7.9% increase in FVC on 400 mg vs -0.6% on 40 mg

(p=0.0004). 3.9% on 240 mg, 1.5% on 120 mg

Secondary end points:

Other lung function 11.9% increase in MMEF on 400 mg (vs -0.3% on 40

measures; mg, change did not reach significance)

CF Questionnaire Improved 6.3 points on 400 mg vs -0.2 on 40 mg

Safety/adverse events No serious adverse events on 400 mg Bronchitol

Forward-Looking Statements

The statements contained in this media release that are not purely historical are forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended. Forward-looking statements in this media release include statements regarding our expectations, beliefs, hopes, goals, intentions, initiatives or strategies, including statements regarding the potential for Aridol and/or Bronchitol. All forward-looking statements included in this media release are based upon information available to us as of the date hereof, and we assume no obligation to update any such forward-looking statement as a result of new information, future events or otherwise. We cannot guarantee that any product candidate will receive FDA or other regulatory approval or th
'/>"/>

SOURCE Pharmaxis Ltd
Copyright©2008 PR Newswire.
All rights reserved

2

GOOD

Page: 1 2 3 4
Related medicine technology :

1. Pharmaxis Long-Term Safety Study of Bronchitol Completes
2. Pharmaxis Establishes Named Patient Program for Bronchitol
3. Pharmaxis Concludes Special Protocol Assessment with FDA for Bronchitol Phase 3 Trial
4. Promising Cystic Fibrosis Compound on Track for Development
5. Symbollon Pharmaceuticals, Inc. Evaluates the Clinical Effects of IoGen(TM) on Fibrocystic Breast Disease
6. Pediatric Pulmonary Expert Comments on Study of Lung Transplants for Cystic Fibrosis
7. Cystic Fibrosis Foundation Reports Upward Trend for Key Health Outcomes
8. Cystic Fibrosis Foundation Announces Positive Early Results for Phase 2 Clinical Trial of VX-770 - an Oral Compound to Treat CF
9. Lung Transplants in Cystic Fibrosis Patients With Life-Threatening Bacteria Sparks Debate at ISHLT Meeting
10. PTC Therapeutics Announces Data Supporting Cough Frequency as a New Outcome Measure in Evaluating Treatments for Cystic Fibrosis
11. PTC Therapeutics Announces Data from Additional Clinical Studies of PTC124 in Cystic Fibrosis Confirming Activity

Post Your Comments:

(Date:5/24/2013)... LOVELAND, Colo. , May 24, 2013 Heska Corporation ... veterinary diagnostic and specialty products, announced today that Dr. ... executive officer, and Jason Napolitano , executive ... Second Annual Marcum MicroCap Conference, which is being held May ... at the Grand Hyatt Hotel. The Company,s ...

(Date:5/24/2013)... 24, 2013 In accordance with Rule 17.1 and ... of the United States Exchange Act, Echo Pharma Acquisition Limited ... Elan Corporation (NYSE: ELN). Background On ... an offer for the entire of the issued and to ... "Original Offer"). On 20 May 2013, Royalty ...

(Date:5/24/2013)... England and BOSTON , May ... drug discovery and development company, is pleased to announce that it ... Consultant to augment the Company,s business development capabilities in ... has more than 15 years of experience in business development, licensing ... Perlegen Sciences, Inc., Roche Pharma ( Japan ), Nippon ...

[0] Heska Corporation To Present At The Second Annual Marcum LLP MicroCap Conference [0] Royalty Pharma Discloses Acceptance Levels of Original Offer for Elan Pursuant to Irish and United States Regulatory Requirements [0] Heptares Augments Business Development Capabilities in Japan and Other Asian Territories

... WORCESTER, Mass., Jan. 6, 2011 Generex Biotechnology ... GNBT ), together with its wholly-owned immunotherapeutic ... and RXi Pharmaceuticals Corporation ( www.rxipharma.com ) (NasdaqCM: ... announced that they have obtained positive early research ...

... Nutrastar International Inc. (OTC Bulletin Board: NUIN ... supplier of premium branded Traditional Chinese Medicine ("TCM") consumer ... in the upcoming Cowen and Company 9th Annual Consumer ... Times Square (270 West 43rd Street) in New York ...

Cached Medicine Technology:Generex and RXi Pharmaceuticals Announce Positive Research Data Using RNAi Technology in the Development of Therapeutic Vaccines for Cancer 2 Generex and RXi Pharmaceuticals Announce Positive Research Data Using RNAi Technology in the Development of Therapeutic Vaccines for Cancer 3 Generex and RXi Pharmaceuticals Announce Positive Research Data Using RNAi Technology in the Development of Therapeutic Vaccines for Cancer 4 Generex and RXi Pharmaceuticals Announce Positive Research Data Using RNAi Technology in the Development of Therapeutic Vaccines for Cancer 5 Nutrastar to Present at the Cowen and Company 9th Annual Consumer Conference in NYC 2 Nutrastar to Present at the Cowen and Company 9th Annual Consumer Conference in NYC 3

Generex and RXi Pharmaceuticals Announce Positive Research Data Using RNAi Technology in the Development of Therapeutic Vaccines for Cancer Nutrastar to Present at the Cowen and Company 9th Annual Consumer Conference in NYC

(Date:5/25/2013)... According to a new market report,"Global Homeland ... MarketsandMarkets is expected to reach $544.02 Billion by ... and studies the major market drivers, restraints, and ... of the World. , Browse:, , ... 87 Figures , 175 Pages and ...

(Date:5/25/2013)... 2013 Dr. Farooq Ashraf, founder of ... Dubai, has announced his practice’s adoption of The iFS ... FDA-cleared femtosecond laser proven with more than 10 years ... of LASIK. , “We are happy to announce that ... at our Dubai LASIK practice,” Ashraf said Thursday. “We ...

(Date:5/25/2013)... 25, 2013 Acuity Games ’ innovative ... version of Word Hunt is available today, expanding ... Edge Match, Flash 2, Sudoku and Matchematics will roll out ... gameplay and revolutionary lifetime brain fitness measurement have been re-optimized ... “100 years of brain fitness measurement in your pocket. ...

(Date:5/25/2013)... May 25, 2013 IBISWorld estimates that revenue ... an average annual rate of 28.7% to $1.0 billion in ... 2013. From 2002 and 2008, no new cell therapy products ... relatively modest growth during that period. In the years since, ... new products. This factor contributed to the industry's fast growth ...

(Date:5/25/2013)... For college students, few events can ... are turning to prescription stimulants like Adderall to ... on this, go to http://www.sciencedaily.com/releases/2013/05/130501145151.htm . , ... students who pick up Adderall, “just to help ... a physical and psychological dependency. While initially they ...

Breaking Medicine News(10 mins):Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 2 Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 3 Health News:Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets 4 Health News:Atlanta Vision Clinic Acquires the Latest in Blade-Free Lasik Technology Bringing Dubai Patients the Intralase Method 2 Health News:Acuity Games Apps Come to the iPhone 2 Health News:Slow Healing: Cell Therapy in the US Industry Market Research Report Now Available from IBISWorld 2 Health News:Slow Healing: Cell Therapy in the US Industry Market Research Report Now Available from IBISWorld 3 Health News:Addiction and Drug Abuse: Study Drug Adderall Abuse Spikes During Finals 2

[0] Homeland Security Market to Reach $544.02 Billion by 2018 at a CARC of 5.54% - New Report by MarketsandMarkets [0] Atlanta Vision Clinic Acquires the Latest in Blade-Free Lasik Technology Bringing Dubai Patients the Intralase Method [0] Acuity Games Apps Come to the iPhone [0] Slow Healing: Cell Therapy in the US Industry Market Research Report Now Available from IBISWorld [0] Addiction and Drug Abuse: Study Drug Adderall Abuse Spikes During Finals

... disease during National Colorectal Cancer Awareness MonthNORTHFIELD, Ill., March ... cancer among men and women in the United States, ... each year, pathologists say timing is critical when it ... could save your life or the life of a ...

... a gene circuit that permits precise tuning of a gene,s ... more accurate analysis of the gene,s role in normal and ... by installing a negative feedback loop in the synthetic gene ... a team led by scientists at The University of Texas ...

... 2009) -- Health information technology programs implemented in New ... years after being established, and could serve as models ... investigators at Weill Cornell Medical College. , "Programs such ... delivered nationally and locally," says senior author Dr. Rainu ...

... Conn., March 10 Stamford-based Olympus Partners is ... International Corp. from The Hansen Corporate Group. ... change its name to The Ritedose Corporation (TRC).TRC ... the United States. In the BFS process, ...

... Gundersen Lutheran is the first in the nation to ... Quality Measures for Breast Centers(TM) (NQMBC) Program. This distinguished ... of quality breast health care. It,s the latest in ... System, based in La Crosse, Wis., a national leader ...

... Pharmaceutical Marketers Can Leverage Social Media-Style Communities to ... Spigit, the leader in idea and innovation management ... co-founder and CTO Padmanabh Dabke will deliver the ... 8th Annual Forum on eMarketing for the ...

Cached Medicine News:Health News:Understand Colon Cancer with MyBiopsy.Org; Schedule a Screening Test at MyHealthTestReminder.Org 2 Health News:Understand Colon Cancer with MyBiopsy.Org; Schedule a Screening Test at MyHealthTestReminder.Org 3 Health News:Synthetic gene circuit allows precise dosing of gene expression 2 Health News:Synthetic gene circuit allows precise dosing of gene expression 3 Health News:New York State health IT strategy may be model for the nation 2 Health News:New York State health IT strategy may be model for the nation 3 Health News:Gundersen Lutheran Breast Center Earns Top National Honor 2 Health News:Spigit Enterprise Community Expert to Highlight Enterprise 2.0 Apps for Pharma Companies at Annual CBI eMarketing Forum 2 Health News:Spigit Enterprise Community Expert to Highlight Enterprise 2.0 Apps for Pharma Companies at Annual CBI eMarketing Forum 3

Understand Colon Cancer with MyBiopsy.Org; Schedule a Screening Test at MyHealthTestReminder.Org Synthetic gene circuit allows precise dosing of gene expression New York State health IT strategy may be model for the nation Olympus Acquires Holopack International Corp.Gundersen Lutheran Breast Center Earns Top National Honor Spigit Enterprise Community Expert to Highlight Enterprise 2.0 Apps for Pharma Companies at Annual CBI eMarketing Forum

LCD chart display...

... Flexible biopsy forceps are extremely delicate ... incompetent repair source, they can easily be ... turn, damage your endoscopes. , On the ... flexible biopsy forceps can have a virtually ...

Mobile offers full life cycle service for Sp02 accessories that are the vital link between pulse oximeter and patient...

... With our factory-quality repairs, physicians know ... why more hospitals turn to Mobile Instrument ... We offer a full line of carbide ... our four-way quality control process. You'll enjoy ...

Medicine Products:

Velo 4000M LCD Chart Display Flexible Biopsy Forceps and Related Products Pulse Oximeter Repair Needle Holder Repair