Navigation Links
Broad Patent Protection Granted for iBio Immunomodulator
Date:5/8/2012

NEWARK, Del., May 8, 2012 /PRNewswire/ -- iBio, Inc. (NYSE AMEX: IBIO) today announced issuance of a US patent covering compositions of matter and methods of use of modified lichenase B polypeptides comprising the Company's iBioModulator™ platform. The new patent, which provides broad protection of the platform, is US Patent 8,173,408, entitled "Recombinant Carrier Molecule for Expression, Delivery and Purification of Target Polypeptides."

(Logo:  http://photos.prnewswire.com/prnh/20120419/NY91086LOGO )

The iBioModulator platform has been shown to significantly modify the immune response to a vaccine in two important ways. It increases the strength of the initial immune response to a vaccine antigen (as measured by antibody titer).  It also extends the duration of the immune response. These results demonstrate that the use of the iBioModulator platform can lower vaccine antigen requirements and enable fewer doses to establish prolonged immunity. The ability to provide better immune response and longer-term protection without booster inoculations adds significant value to a vaccine by reducing the overall costs and logistical difficulties of its use while effectively reaching a higher proportion of the target population.

"The iBioModulator is another platform, separate and independent from our plant-based biologics technology," said Robert B. Kay, iBio's Chairman and CEO. "Although we recommend its use together with our iBioLaunch platform to achieve maximum efficiency in producing the fused protein, the iBioModulator is usable independently and is applicable to recombinant vaccines made with any system.  We expect strong interest in its use."

Efficacy studies in animals have confirmed the superior performance of certain iBioModulator-based vaccines, and ongoing tests will provide additional data about the further extent to which prolonged immunity is conferred by the iBioModulator technology. On the strength of results obtained to date, iBio has broadened its commercial program to include additional vaccine applications for preclinical evaluation.

Among the positive tests completed to demonstrate the ability of the iBioModulator platform to improve the performance of vaccines are the following:

  • An iBioModulator-Pfs 25 antigen malaria vaccine candidate in advanced pre-IND testing elicited transmission blocking activity at lower doses and for a longer period of time following immunization compared to a vaccine candidate containing the antigen alone.
     
  • Therapeutic HPV (human papilloma virus) vaccine candidates constructed with iBioModulator provided superior protection from HPV-16 E7-induced tumors and extended survival in a mouse model when compared with vaccination with native E7 protein alone. Effective therapeutic vaccination to treat HPV-induced cancer has been a long-desired but difficult to achieve objective of healthcare professionals. The iBioModulator platform offers a new and promising approach to addressing this important goal.
     
  • iBioModulator has been used as a fusion to express peptide or protein domain antigens in a number of other successful vaccine candidates, including those for plague and anthrax.
  • The iBioModulator also has been used by scientists at iBio, Inc.'s research and development partner, the Fraunhofer USA Center for Molecular Biotechnology, to improve the solubility and stability not only of recombinant vaccine antigens, but other proteins as well.  Ongoing studies will include evaluation of the benefits of using the iBioModulator in the development and production of therapeutic product candidates.

    iBio plans to offer the benefits of the iBioModulator platform to collaborators and licensees of product candidates initially developed by iBio and also through licenses for products developed independently by or for licensees. Features of vaccines utilizing the iBioModulator platform such as those already observed in the animal studies should enable licensees to enjoy a stronger competitive position in worldwide vaccine markets.

    About iBio, Inc.iBio develops and offers product applications of its iBioLaunch™ platform, providing collaborators full support for turn-key implementation of its technology for both proprietary and biosimilar products. The iBioLaunch platform is a proprietary, transformative technology for development and production of biologics using transient gene expression in unmodified green plants. Advantages over other systems include: success with proteins difficult or impossible to produce with other methods; broadly applicable to biologics, including monoclonal antibodies, other therapeutic proteins and vaccines; enables rapid development and validation of modular, scalable, and optionally robotic, multi-product manufacturing facilities; production time measured in weeks instead of months or more. Additional benefits include a practically unlimited surge capacity for remedial action against bioterrorism and pandemic disease; product entry that is unconstrained by traditional process patents, and significantly lower capital and operating costs for comparable production. The iBioModulator™ platform is complementary to the iBioLaunch platform and enables significantly improved vaccine products with higher potency and greater duration of effect. Further information is available at: www.ibioinc.com.

    Forward-Looking StatementsStatements included in this news release related to iBio, Inc. may constitute forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements involve a number of risks and uncertainties such as competitive factors, technological development, market demand, and the Company's ability to obtain new contracts and accurately estimate net revenues due to variability in size, scope and duration of projects. Further information on potential risk factors that could affect the Company's financial results can be found in the company's Reports filed with the Securities and Exchange Commission.Contacts:Corporate:

    Investor:Robert Erwin, PresidentDouglas BeckiBio, Inc.

    iBio, Inc.302-355-2335

    302-355-9452rerwin@ibioinc.com

    ir@ibioinc.com 


    '/>"/>

    SOURCE iBio, Inc.
    Copyright©2010 PR Newswire.
    All rights reserved

    Related medicine technology :

    1. Olympus Broadens Portfolio With a Suite of New Single-Use Aspiration Needles
    2. Ethicon Endo-Surgery Receives 510(k) Clearance for New ENSEAL® G2 Curved and Straight Tissue Sealers Line -- Broadest Range of Advanced Bipolar Tissue Sealers Available for Open and Minimally Invasive Surgery
    3. U.S. Soldiers and Veterans at Home and Abroad Touched by Lifesaving Products From Philips Healthcare
    4. New Data From REALISTIC Study Showed Cimzia® (certolizumab pegol) Provided Rapid and Sustained Efficacy, Over 28 Weeks, in a Broad Population of Patients With Moderate to Severe Rheumatoid Arthritis (RA) Including Those Who Discontinued Prior Anti-T
    5. IRIDEX Launches New MicroPulse™ Module Targeting the Broad Ophthalmology Laser Photocoagulation Market
    6. ACT Secures First Patent for Generating Hemangioblast Cells to Treat a Broad Spectrum of Vascular and Hematopoietic Disorders
    7. Boehringer Ingelheim Broadens Its Breast Cancer Clinical Trial Program for the Investigational Compound Afatinib
    8. HYCOR Broadens Diagnostic Offerings, Announces Agreements to License Biomarkers for Celiac Disease and Rheumatoid Arthritis
    9. InspireMD Broadens Global Distribution Network; Signs Distributor for the Russian Federation
    10. Spectros Corporation Introduces Continuum®, a Broadband Infrared Sensor for Brain and Gut Oximetry
    11. Ethicon Endo-Surgery to Showcase Broadest Spectrum of Innovative Bariatric Surgical Options, Physician Best Practices and Mobile/Web-Based After-Care Patient Programs at ASMBS
    Post Your Comments:
    *Name:
    *Comment:
    *Email:
    (Date:2/11/2016)... SAN FRANCISCO , Feb. 11, 2016  Kindred ... focused on saving and improving the lives of pets, ... Technical Section of the New Animal Drug Application (NADA) ... the pivotal field study (KB0120) of Zimeta for the ... by the Company. --> ...
    (Date:2/11/2016)... SAN FRANCISCO , Feb. 11, 2016   ... the advancement of new health technologies, announced today " ... outstanding achievements in health tech over the past ten ... For nearly a decade, Health 2.0 has served ... and showcased and connected with thousands of technologies, companies, ...
    (Date:2/11/2016)... 11, 2016  MiMedx Group, Inc. (NASDAQ: MDXG ... membrane and other birth tissues, human skin and bone, ... market advanced products and therapies, announced today that it ... Healthcare Conference in New York , ... Michael J. Senken , Chief Financial Officer and ...
    Breaking Medicine Technology:
    (Date:2/11/2016)... ... February 11, 2016 , ... Dr. Sadati’s recent feature in ... Along with performing procedures, the magazine also highlights that Dr. Sadati has pioneered ... of the most common procedures he performs is his natural facelift. “As people ...
    (Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... The president ... DoD Military Health System but would shift more of the cost burden to military ... TRICARE-reform plan laid out in the defense budget as including limited quantifiable benefit fixes ...
    (Date:2/11/2016)... ... February 11, 2016 , ... ... and women’s health, is pleased to announce the promotions of Allison Kelly to ... team, Steve Catone to executive vice president of North American capital sales, and ...
    (Date:2/11/2016)... Laurel, NJ (PRWEB) , ... February 11, 2016 ... ... announces the call for nominations seeking candidates for the Board of Commissioners. Individuals ... with passion, skills and experience with diversity of clinical practice settings and across ...
    (Date:2/11/2016)... , ... February 11, 2016 , ... ... of a master charity program created to assist the people of their local ... closely with nonprofit organizations and community leaders. Their hope is to bring awareness ...
    Breaking Medicine News(10 mins):