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British Midlands University Announces Use of Gene Technology to Fight Lethal Hospital Acquired Infection
Date:1/28/2009

s involved in its spread and the way in which it causes disease."

The Centre for Healthcare Associated Infections (CHAI) was established at the University of Nottingham in late 2006. CHAI consists of researchers from the University, together with clinical colleagues from Nottingham University Hospitals NHS Trust, which allows a unique holistic approach to HAI research. Researchers in CHAI have made major breakthroughs in our understanding of the basic biology of C.difficile and MRSA that will assist efforts to develop new antibiotics and better diagnostic tests to identify these pathogens.

During the three-year study, scientists at Nottingham will use a technology called ClosTron to produce mutant versions of the hypervirulent strains. They will knock out genes one by one and then compare the mutant version to the standard organism to assess the function of each cell.

The British Midlands region, comprising the East and the West Midlands in the centre of the UK, is at the heart of the UK's biopharma industry, which is the largest in Europe, generating revenues in excess of $8.6 billion per year. Strong links between academia and industry across the region, have resulted in the creation of many dedicated science parks and incubators. These include BioCity Nottingham, the largest bioscience innovation and incubation centre in the UK.

Bio-research in the Midlands has attracted a number of the world's most active pharma and biotech companies, including AstraZeneca, Aventis, Bayer, Boots, GeneSeek, Novartis, Sunrise Medical, Salts Healthcare, Bibby Sterilin, Cobra Biomanufacturing, Sterilox and 3M.

"Universities in the Midlands continue to set the bar in innovation and discovery," said Vern

Sebby, President and CEO of British Midlands Development Corporation, "The British Midlands is one of Europe's premier locations for the advancement of medicine and life sciences. All of the
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SOURCE British Midlands Development Corporation
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