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Breast Health Study Advances Safety Profile for Soy-Based Natural S-equol Supplement Designed to Manage Menopause Symptoms
Date:9/13/2011

times larger than the levels needed to induce comparable activity with 17-beta estradiol (0.05 +/- 0.00 to 0.16 +/- 0.13 pico moles,).

Authors of the study are Atsuko Onoda, M.S., Tomomi Ueno, M.S., and Shigeto Uchiyama, M.S. of Otsuka Pharmaceutical Co, LTD, Saga, Japan; and Kiyoko Kato, Ph.D., M.D., and Norio Wake, Ph.D., M.D., of the Department of Obstetrics and Gynecology at the Graduate School of Medical Sciences of Kyushu University, Fukuoka, Japan.  An initial report on the study data was presented in a poster at the Women's Health Congress 2011 in April.

How SE5-OH Ingredient is Made
SE5-OH is the product of fermentation of whole soy germ by the bacterial strain Lactococcus 20-92 using a patented and proprietary process by the Otsuka Pharmaceutical Co., Ltd.  The process results in the conversion of the daidzein to Natural S-equol.  SE5-OH is created under current Good Manufacturing Practices.  Following fermentation, the bacteria undergo heat denaturation and are deactivated.  The process is designed to produce a Natural S-equol rich product, or nutraceutical ingredient.  The ingredient has self-affirmed GRAS (Generally Recognized As Safe) status.

Development and ongoing research of SE5-OH containing Natural S-equol is conducted by the Saga Nutraceuticals Research Institute of Otsuka Pharmaceutical Co., Ltd.

About Pharmavite LLC:  For 40 years, Pharmavite has earned and maintained the trust of healthcare professionals, consumers, and retailers by manufacturing high-quality vitamins, minerals, herbs and other dietary supplements that are safe, effective and science-based.  Nature Made® is the number one selling dietary supplement brand in the food, drug, club and mass channels.  The dietary supplement industry is regulated by the U.S. Food and Drug Administration and the Federal Trade Commission, as well as by government agencies in each of the 50
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