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Breast Health Study Advances Safety Profile for Soy-Based Natural S-equol Supplement Designed to Manage Menopause Symptoms
Date:9/13/2011

hat occurs naturally in soy) or a soy-free diet.

For the study, investigators implanted 71 healthy female mice - from which the ovaries had been surgically removed - with pellets containing 2 milligrams (mg) of 17-beta estradiol, a form of estrogen.  One week later, the researchers injected the mice with MCF-7-E10 cells, which are estrogen-dependent, human breast cancer cells that have both alpha and beta estrogen receptors.  When the cells had grown to tumors that averaged 34 square millimeters in size, nine of the mice continued unaltered, as a control, while the rest of the mice had their estrogen pellets removed.

The 62 mice without estrogen then received one of four diets daily for 25 weeks: either 250 or 500 parts-per-million (ppm) of the soy isoflavone genistein, SE5-OH or purified S-equol or no soy isoflavones.  The researchers measured the size of the implanted tumors, total body weight and food intake weekly.

At 25 weeks, the tumor sizes did not significantly differ and for the 250 or 500 ppm groups, respectively, averaged 61 square millimeters in the estrogen pellet-free control group, 96 and 79 square millimeters in the genistein groups, 65 and 80 square millimeters in the SE5-OH groups, and 62 and 56 square millimeters in the S-equol groups.  In comparison, by week 10, the mice had estrogen pellets had tumors that averaged 269 +/- 72.1 square millimeters.

In other studies, doses of the supplement SE5-OH containing Natural S-equol ranging from 10 to 30 mg daily were effective in reducing menopausal symptoms without significant adverse events.

Laboratory tests on MCF-7-E10 cells and Estrogen Receptors
In tests using laboratory cultures of MCF-7-E10 cells, Natural S-equol and SE5-OH containing Natural S-equol did not stimulate estrogen receptor activity or the multiplication of MCF-7-E10 cells unless given at concentrations that were 10,000 to one million
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