Navigation Links
Breast Health Study Advances Safety Profile for Soy-Based Natural S-equol Supplement Designed to Manage Menopause Symptoms
Date:9/13/2011

hat occurs naturally in soy) or a soy-free diet.

For the study, investigators implanted 71 healthy female mice - from which the ovaries had been surgically removed - with pellets containing 2 milligrams (mg) of 17-beta estradiol, a form of estrogen.  One week later, the researchers injected the mice with MCF-7-E10 cells, which are estrogen-dependent, human breast cancer cells that have both alpha and beta estrogen receptors.  When the cells had grown to tumors that averaged 34 square millimeters in size, nine of the mice continued unaltered, as a control, while the rest of the mice had their estrogen pellets removed.

The 62 mice without estrogen then received one of four diets daily for 25 weeks: either 250 or 500 parts-per-million (ppm) of the soy isoflavone genistein, SE5-OH or purified S-equol or no soy isoflavones.  The researchers measured the size of the implanted tumors, total body weight and food intake weekly.

At 25 weeks, the tumor sizes did not significantly differ and for the 250 or 500 ppm groups, respectively, averaged 61 square millimeters in the estrogen pellet-free control group, 96 and 79 square millimeters in the genistein groups, 65 and 80 square millimeters in the SE5-OH groups, and 62 and 56 square millimeters in the S-equol groups.  In comparison, by week 10, the mice had estrogen pellets had tumors that averaged 269 +/- 72.1 square millimeters.

In other studies, doses of the supplement SE5-OH containing Natural S-equol ranging from 10 to 30 mg daily were effective in reducing menopausal symptoms without significant adverse events.

Laboratory tests on MCF-7-E10 cells and Estrogen Receptors
In tests using laboratory cultures of MCF-7-E10 cells, Natural S-equol and SE5-OH containing Natural S-equol did not stimulate estrogen receptor activity or the multiplication of MCF-7-E10 cells unless given at concentrations that were 10,000 to one million
'/>"/>

SOURCE Pharmavite LLC
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Positive Results from Phase 2 Clinical Study of NKTR-102 in Metastatic Breast Cancer Presented in Oral Session at the ASCO 2011 Breast Cancer Symposium
2. Naviscan Receives CE Mark Approval for High-Resolution Breast PET and PET-Guided Biopsy
3. Boehringer Ingelheim Broadens Its Breast Cancer Clinical Trial Program for the Investigational Compound Afatinib
4. SimonMed and Cox Business Bring Breast Tomosynthesis to Arizona
5. Generex Subsidiary Antigen Express Provides Update on Phase 2 Breast Cancer Immunotherapy Program
6. International St. Gallen Expert Panel Highlights Importance of Molecular Subtyping in Breast Cancer Treatment
7. SIUH Offers New 5-Day Breast Cancer Therapy
8. Siemens Partners with American Cancer Society to Make Strides Against Breast Cancer
9. Medela Announces 2011 Breastfeeding Hall of Excellence Inductees to Nationally Recognize Exceptional Breastfeeding Advocates
10. Evergreen Hospital Launches Revolutionary Breast Cancer Detection and Diagnostic Imaging Technology
11. A Simple Way to Detect Breast Cancer at Stage 0 Discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... TOWN, South Africa , Jan. 23, 2015   ... distributor of personal protective equipment for all forms of ... the flagship Leatt-Brace® neck brace, announced today that the ... racing federation, now requires all riders to wear a ...
(Date:1/23/2015)... Gem Pharmaceuticals announced today that the initial soft ... Company,s Phase 2 clinical trial.  This open-label study will ... GPX-150 (an investigational medication), in approximately 30 adults as ... Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO GPX-150 ...
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held ... into an exclusive distributor agreement with ITOCHU Corporation (Tokyo ... therapy system for the treatment of cancer in ... system, is the world,s first and only MRI-guided radiation ...
Breaking Medicine Technology:Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 2Leatt Announces Neck Braces Now Required For Motocross/Minicross Racing In Italy 3Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2
... March 29, 2011 Sigma-Aldrich Corporation (Nasdaq: SIAL ... new website, www.sigma-aldrich.com . The new site has been ... to help researchers more easily find the information, tools, products ... Company plans to continue to roll out innovative upgrades to ...
... A woman,s face tells her story but sometimes showing a ... and more, the quest continues for new ways to keep ... new Face Forward survey commissioned by Ulthera ® (the ... the FDA with a non-invasive lift indication), 83 percent of ...
Cached Medicine Technology:Sigma-Aldrich Unveils Dynamic New Web Presence 2Sigma-Aldrich Unveils Dynamic New Web Presence 3What Would Women Give Up for a More Youthful Face? 2What Would Women Give Up for a More Youthful Face? 3
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David ... Show to bestow a Juvent Sports Achievement award upon ... McKitrick. The award commemorated and congratulated McKitrick for her ... won her first amateur tournament in 1979 and most ...
(Date:1/22/2015)... 2015 Autocarinsurancebest.com has released a new blog ... auto insurance policy . , Auto insurance quotes help ... is no longer necessary to call an agent or visit ... online on a single website: http://autocarinsurancebest.com/ . , Every ...
(Date:1/22/2015)... Plainsboro, NJ (PRWEB) January 22, 2015 ... advocate and keynote speaker at the upcoming 32nd ... by ACCME-accredited Physicians’ Education Resource®, LLC (PER®) , ... breast would have gone undetected if she had not ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 Recently, Weddingshe.com has ... catalog, and has announced its highest annual revenues in the ... on its popular glamorous wedding dresses. , According to the ... important wedding dress promotions for them in 2015. This point ...
(Date:1/22/2015)... WASHINGTON, DC (PRWEB) January 22, 2015 ... conditions in vulnerable communities and cause financial distress to ... report by analysts at Howard University’s Center on Race ... of dollars in economic activity, payday loans at the ...
Breaking Medicine News(10 mins):Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2
... Derek Kirchen, 67, who had suffered pneumonia eight times and ... their wits end, making sense of the symptoms and providing ... clues, doctors had cautioned Kirchen that the symptoms may be ... surgery, Dr Syed Tariq, a respiratory physician, stumbled upon a ...
... using dummy due to different developmental, hygienic or aesthetic reasons. ... dummies are bad for babies and parents should be in ... 20 studies conducted over the world since from past decade ... dummies are prone to reject or breastfeed for a shorter ...
... We might feel that we have forgotten certain things in ... that whatever we have forgotten does still stay in our ... and Roberto Cabeza of Duke University, conducted a study in ... we think it, does. According to the online edition of ...
... May that one adult and two children have been diagnosed with ... statement confirming that there have been three linked cases of E.coli ... these cases have a link with J&H Cairns, a butcher in ... no conclusive evidence yet that J&H Cairns is the source of ...
... UN sponsored conference on aviation flu has called ... facility involving all relevant institutions across the globe, ... bird watchers and wildlife conservation societies to check ... ,Scientists attending the conference convened by the UN ...
... led young people to name heroin as a loser ... which includes providing alternative narcotics and needle exchange programs, ... to consider the substance ‘loser drug,’ a Lancet study ... in Zurich said: The policy provides an alternative narcotics ...
Cached Medicine News:Health News:Diagnosis On a Fourth Patient Confirmed To Be E.Coli 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: