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Breast Health Study Advances Safety Profile for Soy-Based Natural S-equol Supplement Designed to Manage Menopause Symptoms
Date:9/13/2011

com.

S-equol [7-hydroxy-3-(4'-hydroxyphenyl)-chroman] is a compound resulting -- when certain bacteria are present in the digestive tract -- from the natural metabolism, or conversion, of daidzein, an isoflavone found in whole soybeans.  Not everyone can produce S-equol after soy consumption, as the production depends on the types of bacteria present in the large intestine and may be influenced by the amount of soy consumed. About 50 percent of Asians and 20 to 30 percent of North Americans and Europeans, who in general consume less soy than Asians, have the ability to produce high levels of S-equol naturally.  Preliminary evidence from observational studies suggests that among Japanese women, those who produce S-equol naturally may have fewer menopausal symptoms.  Controlled clinical trials have documented that a supplement containing Natural S-equol reduces the frequency of hot flashes as well as muscle discomfort associated with menopause, both in Japan and the United States.

"S-equol binds to the same estrogen receptors as naturally occurring, endogenous estrogen, but with a stronger affinity for the estrogen beta receptor.  Because of the actions that S-equol has that mimic some but not all activities of naturally occurring estrogen, it is important for us to explore the effects of S-equol as well as of SE5-OH containing Natural S-equol on human breast cancer cells," explains Jenks.

About 60 to 70 percent of human breast cancers are estrogen-positive, in which estrogen, the main sex hormone in women, acts with high affinity to these receptors and increases the number of cancer cells.

Breast Cancer Tumor Not Influenced by Natural S-equol
No significant differences in the size of human breast tumors occurred between mice that ate diets for 25 weeks containing Natural S-equol, SE5-OH, genistein (an isoflavone t
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