Navigation Links
Breast Cancer Research and Treatment Highlights Development and Validation of BluePrint®
Date:9/19/2011

IRVINE, California and AMSTERDAM, September 19, 2011 /PRNewswire/ --

Agendia, an innovative molecular cancer diagnostics company, today announced that a published report highlighting the development and validation of its 80-gene BluePrint breast cancer profile was published online in Breast Cancer Research and Treatment, a peer-reviewed publication. BluePrint is a part of Agendia's Symphony™ suite of breast cancer products, a comprehensive collection of genetic assays that help address complex treatment decisions for any type and stage of breast cancer. The article notes that, when used in combination with Agendia's FDA-cleared MammaPrint® recurrence test, BluePrint provides an additional level of understanding for physicians, classifying breast cancer patients into Basal-type, Luminal-type A and B, and HER2-type subgroups. Recently, the expert panel at the 12th St. Gallen International Breast Cancer Conference (2011) recommended specific treatments for those particular breast cancer subtypes.

"This article illustrates the vital role of molecular subtyping in the treatment decision process for breast cancer patients. The combination of Symphony's MammaPrint and BluePrint micro-array assays provides physicians with unprecedented insight into their patient's tumor," said Dr. Bernhard Sixt, Agendia's CEO and co-founder. "From just one biopsy sample, Agendia's Symphony suite of tests provides clear insight into who to treat and how to treat them, helping to identify the optimal treatment tailored to each patient's individual needs and genetics."

The article describes molecular subtyping of breast cancer patients as "…important for the proper selection of therapy, as tumors with seemingly similar histopathological features can have strikingly different clinical outcomes." Further, the use of BluePrint may improve clinical management of breast cancer patients by identifying those patients who are most likely to benefit from either chemotherapy or endocrine therapy.

Recent studies have shown that the classification of breast cancer into molecular subtypes is largely represented by the estrogen receptor (ER), progesterone receptor (PR) and the HER2 status of the tumor. Breast cancer can be classified into molecular subtypes by simple hiererarchical clustering of breast tumors according to their gene expression patterns.

About Agendia:

Agendia is a leading global commercial molecular diagnostic company that develops and markets genomic-based diagnostic products that improve the quality of life for cancer patients and simplifies complex treatment decisions for their physicians. Agendia's Symphony™ suite of breast cancer products is based on the analysis of hundreds of genes in a patient's breast and provides unprecedented biological insight to address complex treatment decisions. Symphony includes MammaPrint, the first and only FDA-cleared IVDMIA breast cancer recurrence assay, as well as BluePrint, a molecular subtyping assay, TargetPrint®, an ER/PR/HER2 expression assay, and TheraPrint®, a therapy selection assay. Together, these tests help physicians determine a patient's individual risk for metastasis, which patients will benefit from chemo or hormonal therapy, and which patients do not require these treatments and can instead be treated with other less arduous and costly methods.

In addition to the Symphony suite of tests, Agendia has a rich pipeline of genomic products in development based on its world-class genomic platform. The company also collaborates with pharmaceutical companies to develop companion diagnostic tests in the area of oncology and is a critical partner in the ISPY-2 and MINDACT trials.

Agendia was founded in 2003 as a spin-off of the Netherlands Cancer Institute and is based in Irvine, California, United States, and Amsterdam, the Netherlands. For more information, please visit http://www.agendia.com.

 



'/>"/>

SOURCE Agendia B.V.
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
2. Xeloda XeNA Study Analyses of Xeloda, Docetaxel and Herceptin Combination Therapy for Metastatic Breast Cancer Featured at Major New Breast Cancer Symposium
3. Xeloda(R) XeNA Study Analyses of Xeloda, Docetaxel and Herceptin Combination Therapy for Metastatic Breast Cancer Featured at Major New Breast Cancer Symposium
4. Kosans Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
5. EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
6. Peregrine Pharmaceuticals Submits Clinical Protocol to Initiate Bavituximab Phase II Trial in Patients With Metastatic Breast Cancer
7. FDA Approves Lillys Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women
8. New Study Demonstrates 4 Year Olds Fed Enfamil LIPIL(R) as Infants Have Brain and Eye Outcomes Similar to Breastfed Babies
9. Symbollon Pharmaceuticals, Inc. Evaluates the Clinical Effects of IoGen(TM) on Fibrocystic Breast Disease
10. Spit for the Cure Offers Unique Opportunity for Women to Participate in Breast Cancer Research
11. Genomic Health Announces Preliminary Results From a Study of Oncotype DX(TM) in Node-Positive Breast Cancer Patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/9/2016)... , Feb. 9, 2016  The Parenteral Drug ... professionals developing and manufacturing sterile drug products, today ... Regulatory Guidance Comparison – With link to Comparison ... issued by the U.S. FDA, the EU, the ... --> --> ...
(Date:2/8/2016)... , Feb.8, 2016 Alzheimer Diagnostic Tests ... Medical Devices sector report , "Alzheimer ... provides an overview of Alzheimer Diagnostic Tests currently ... information on the pipeline products with comparative analysis ... The report reviews major players involved in the ...
(Date:2/8/2016)... Cardiovascular Surgery Devices - Medical Devices Pipeline Assessment, ... report, "Cardiovascular Surgery Devices - Medical Devices Pipeline ... Devices currently in pipeline stage. ... comprehensive information on the pipeline products with comparative ... development. The report reviews major players involved in ...
Breaking Medicine Technology:
(Date:2/10/2016)... ... 2016 , ... Ross A. Clevens, MD, FACS , ... a new addition to their growing practice. Beginning this month, Teresa Imperiale-Westerfield, a ... performing cosmetic procedures including injectables, fillers and laser treatments. A master ...
(Date:2/10/2016)... TN (PRWEB) , ... February 09, 2016 , ... ... to sports concussion, yet the cause of injury may be one of many ... two-day advanced PT Continuing Education Course , Mastering Rehab Solutions for ...
(Date:2/9/2016)... ... February 09, 2016 , ... Steven Douglas Associates is a ... Florida Event, an upscale fundraiser held in South Florida. The Inaugural What’s Your Taste ... This year the event will be held in a new, more causal format at ...
(Date:2/9/2016)... Worth, Texas (PRWEB) , ... February 09, 2016 ... ... and reconstruction firm helping businesses recover after a disaster, announced today the acquisition ... service companies in Hawaii. , “Investing in like-minded companies who excel ...
(Date:2/9/2016)... ... February 09, 2016 , ... URise Products ... newest mobility device, the StandUp Walker. Made entirely in the USA, the StandUp ... 50 years. , StandUp Walker’s novel patent-pending design offers 2-in-1 benefits of ...
Breaking Medicine News(10 mins):