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Braincells, Inc. Announces the Successful Completion of a Multiple Ascending Dose Study of BCI-838, a Group II mGluR2/3 Antagonist, and the Company's Plans for a Proof-of-Concept Study in Patients with Treatment-Resistant Depression
Date:12/5/2012

e potential to significantly improve the way the disease is managed for these patients," said Robert Williamson, Chief Executive Officer.

BCI-632 increases synaptic glutamate by inhibiting the mGlu2/3 auto-receptor, which is located predominantly at the pre-synaptic site.  As in the case of ketamine, the long-lasting efficacy of BCI-632 can be blocked by either inhibition of AMPA receptors, mTOR or the BDNF signaling pathway.  In addition, BCI-632 also stimulates serotonin release and, after chronic dosing, hippocampal neurogenesis. 

 "BCI-838 is an oral prodrug for the active agent BCI-632 that is the leading mGluR2/3 antagonist in development," said John Hutchinson, Ph.D. Senior Vice President of Research.  "The successful completion of this Phase 1 trial, coupled with the encouraging qEEG data, offers promise that the drug will demonstrate efficacy in further clinical studies."

"BCI-838 may yield meaningful clinical benefits for patients suffering from TRD.  We believe that BCI-838 may generate early antidepressant responses similar to ketamine with a better safety profile and less adverse event liability.  Unlike ketamine, BCI-838 is an oral drug with no need for intravenous administration.  Furthermore, the neurogenic effect of BCI-838 in the hippocampus suggests that BCI-838 may be a novel treatment for a broader population of patients with mood or cognitive disorders," said Steven D. Targum. M.D., Chief Medical Officer.  "We look forward to the clinical advancement of this compound in a PoC study targeted for initiation in patients with TRD at the beginning of 2013."

About TRD and MDD

Major Depressive Disorder (MDD) is a highly prevalent disorder causing marked social and economic problems for affected patients and their families.  According to the World Health Organization, MDD is the leading cause of disability worldwide.  MDD is associated with high morbidity contr
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SOURCE BrainCells Inc.
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