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Brain Cancer Drug Pipeline Update 2012
Date:7/16/2012

- Catalytic activity

- Cell adhesion molecule activity

- Chaperone activity

- Complement activity

- Cysteine-type peptidase activity

- Cytokine activity

- DNA binding

- DNA repair protein

- DNA topoisomerase activity

- DNA-directed DNA polymerase activity

- Extracellular ligand-gated ion channel activity

- Extracellular matrix structural constituent

- G-protein coupled receptor activity

- Growth factor activity

- Ion channel activity

- Kinase activity

- Kinase regulator activity

- Ligand-dependent nuclear receptor activity

- Ligase activity

- Lipid kinase activity

- Lipid phosphatase activity

- Molecular function unknown

- Oxidoreductase activity

- Peptidase activity

- Protein binding

- Protein serine/threonine kinase activity

- Protein-tyrosine kinase activity

- Receptor activity

- Receptor binding

- Receptor signaling complex scaffold activity

- Receptor signaling protein serine/threonine kinase activity

- Receptor signaling protein tyrosine phosphatase activity

- RNA binding

- RNA-directed DNA polymerase activity

- Structural constituent of cytoskeleton

- Sugar-phosphatase activity

- Transcription factor activity

- Transcription regulator activity

- Transferase activity

- Translation regulator activity

- Transmembrane receptor activity

- Transmembrane receptor protein tyrosine kinase activity

- Transporter activity

- Voltage-gated ion channel activity

Identified targets are categorized into 19 different primary and alternate sub-cellular localizations:- Cell surface- Centrosome- Clathrin-coated vesicle- Cytoplasm- Cytoplasmic vesicle- Cytosol- Endoplasmic reticulum- Endosome- Extracellular- Golgi apparatus- Integral to membrane- Lysosome- Mitochondrial membrane
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