Navigation Links
Boston University Biomedical Engineers Find Chink in Bacteria's Armor
Date:9/6/2007

limited.

"Importantly, we showed that if you can inhibit or block the bacterial defense mechanisms to hydroxyl radical damage, you can potentiate or enhance the lethality of bactericidal antibiotics. This highlights the value of taking a network biology approach to antibiotics and provides a framework for creating new classes of drugs," said Collins.

"What we think is happening is the cell is getting a signal that says, 'There's something wrong with our energy production system and we need to make more energy.' But, there's really nothing wrong. The cell becomes confused, turns on too many processes at once and it's overwhelmed," said Kohanski.

Previous work by Kohanski and co-lead author Dan Dwyer, a postdoctoral researcher in Collins' lab, revealed the first hints that this underlying pathway exists. In studying bacterial response to a quinolone, an antibiotic that inhibits DNA replication, they noted a surprising change in genes responsible for energy production and iron uptake.

In the current study, the researchers used DNA microarray studies to see if all three classes of bactericidal antibiotics triggered this process. Across the board, they noted increased gene activity along the intracellular assembly lines that make energy for the bacterial cell, just as in the earlier study. They began to deduce the details of the new pathway.

Cells produce free superoxide radicals naturally in oxygen-rich environments, but when they unnecessarily ramp up energy production to a frantic pace - such as when triggered by antibiotics - more radicals get churned out than the cell's safety measures can mop up. The superoxide radicals then pull iron from other components of the cell, and this iron rapidly stimulates production of toxic levels of hydroxyl radicals.

"It's really amazing that despite the diversity of targets, you have everything funneling into this common pathway, where there's a global meltdown occurring," said Dwyer. "The
'/>"/>

SOURCE Boston University College of Engineering
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Boston Scientific Announces Schedule for EuroPcr 2007
2. Boston Life Sciences, Inc. Announces Presentation of Cethrin Phase I/IIa 6-Month Results at 75th Annual Meeting of the American Association of Neurological Surgeons
3. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
4. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
5. Statement by Philip Home Chairman of the RECORD Study Steering Committee and Professor of Diabetes Medicine at Newcastle University in England
6. World First Medical Treatment Announced by Researchers at Queen Mary University London and University of Leicester
7. Alnylam and Stanford University Scientists Discover New Role for microRNAs (miRNAs) in T Cell Biology and Immunity
8. Vaxiion Researchers Discover Novel Vaccine Delivery System in Collaboration with San Diego State University
9. Vical Interim Clinical Results Demonstrate Safety and Tolerability of Inovio Biomedicals Electroporation DNA Delivery Technology
10. Inovio Biomedical Highlights Enhanced DNA Vaccine Potency with Electroporation DNA Delivery Technology and New Devices at Gene Therapy Meeting
11. Inovio Biomedicals DNA Delivery Technology Shows Safety and Enhances Gene Expression & Tumor Responses in Interim Melanoma Clinical Study Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Medical, Inc. (Nasdaq: NXTM ), a leading manufacturer ... Burbank , Chief Executive Officer, and Mathew Towse , ... Annual Canaccord Genuity Growth Conference being held at the InterContinental ... 13 th at 4:30 p.m. ET.  A webcast of ... About NxStage Medical NxStage Medical, ...
(Date:8/1/2014)... , Aug. 1, 2014  Neuland Laboratories Ltd., ... active pharmaceutical ingredients (APIs), complex intermediates and ... in 85 countries, today announced financial results for ... ended June 30, 2014. "Neuland,s results ... flow re-prioritization to accommodate certain customer needs, and ...
(Date:8/1/2014)... Aug. 1, 2014 Dyadic International, Inc. ("Dyadic") ... proprietary technologies are used to develop, manufacture and sell ... biopharmaceutical and industrial enzyme industries, announced today that it ... ended June 30, 2014 after market close on Thursday, ... that day at 5:00 p.m. Eastern Time to discuss ...
Breaking Medicine Technology:NxStage to Present at the 34th Annual Canaccord Genuity Growth Conference 2Neuland Labs Reports First Quarter Fiscal Year 2015 Financial Results 2Neuland Labs Reports First Quarter Fiscal Year 2015 Financial Results 3Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 2Dyadic International To Announce Second Quarter 2014 Financial Results And Host Conference Call On Thursday, August 14, 2014 3
... Second Generation Oxazolidinone Demonstrates Safety and Efficacy with Once-Daily, ... of Treatment , , SAN DIEGO, June ... its Phase 2 clinical trial evaluating the safety and ... the treatment of severe complicated skin and skin structure ...
... sets to be released-- , , PARIS, ... in patients with blepharospasm and cervical dystonia -- one placebo-controlled ... presented at the Movement Disorder Society (MDS) 13th annual International ... Pharmaceuticals, which plans to file a Biologic License Application (BLA) ...
Cached Medicine Technology:Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections 2Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections 3Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections 4Merz Pharmaceuticals Announces Results of Clinical Trials with NT-201(Botulinum neurotoxin type A free from complexing proteins) at Annual Movement Disorders Society Meeting 2Merz Pharmaceuticals Announces Results of Clinical Trials with NT-201(Botulinum neurotoxin type A free from complexing proteins) at Annual Movement Disorders Society Meeting 3Merz Pharmaceuticals Announces Results of Clinical Trials with NT-201(Botulinum neurotoxin type A free from complexing proteins) at Annual Movement Disorders Society Meeting 4
(Date:8/1/2014)... The brain plays a central role in regulating appetite ... important in the brain,s control of food intake and ... this process has been unclear. A new ... demonstrates that PPARγ activity in a type of neuron ... the response to high-fat diet. Sabrina Diano and ...
(Date:8/1/2014)... HealthDay Reporter FRIDAY, Aug. 1, 2014 (HealthDay ... may have significantly less endurance than those who weigh less, a ... half were obese, half were of normal weight -- people who ... longer. Obesity also was associated with less strength, increased discomfort ... 50 to 65 years of age -- neither improved nor reduced ...
(Date:8/1/2014)... U.S. Food and Drug Administration announced on Friday that ... type 2 diabetes. Jardiance (empagliflozin) "can be ... control blood sugar levels in the overall management of ... Drug Evaluation II in the FDA,s Center for Drug ... The FDA also recommended that Jardiance be used along ...
(Date:8/1/2014)... a first-of-its-kind study, researchers at University Hospitals Rainbow Babies ... may be at greater risk for death on a ... on flights worldwide between January 2010 and June 2013 ... under the age of 2. , The study ... rare event of an in-flight pediatric fatality onboard commercial ...
(Date:8/1/2014)... August 01, 2014 Summer is here, and ... active during the summer, and they can be a pain ... ready to help all their customers get rid of ticks ... and 6,000 eggs in the summer, which is why they ... in tall grass and woodland areas and carry a number ...
Breaking Medicine News(10 mins):Health News:Obesity Might Slow You Down at Work 2Health News:Obesity Might Slow You Down at Work 3Health News:FDA Approves New Type 2 Diabetes Drug 2Health News:New research characterizes in-flight pediatric deaths 2Health News:Tis the Season for Tick Prevention 2
... ROCM ) will announce quarterly results after,financial markets ... hold a quarterly conference call to discuss its earnings ... (5:00 p.m. eastern time)., This call is being ... website at http://www.rocm.com . To listen live to ...
... China, Oct. 28 /Xinhua-PRNewswire-FirstCall/ -- China Sky ... "the Company") (Nasdaq: CSKI ), a,leading ... the People,s Republic of China ("PRC"), announced ... purchase a proprietary breast drug from,Harbin Medical ...
... The Los Angeles Shambhala Center,presents a public talk and Zen ... 30 and November 1st and 2nd., This 20th generation ... the first time in Los Angeles at the Shambhala Meditation ... Colorado Blvd.,in Eagle Rock., On Thursday, October 30th, Shibata ...
... 28 /PRNewswire-FirstCall/ - Response Biomedical,Corporation (TSX: RBM, OTCBB: ... an initial closing of the financing announced on ... raising gross proceeds of $4.66,million. The closing involved ... at a price of $0.15 for each unit. ...
... series, Debating Health: Election 2008, the Harvard Public Opinion Research ... Harris Interactive conducted a new survey focused on whether voters ... great deal of difference" in the state of the nation,s ... been made of voter cynicism in recent times, a majority ...
... that was 29 days or older faced twice the risk ... receive a transfusion of stored blood that is 29 days ... more serious infections compared to those who get "fresher" blood, ... current U.S. regulations set the upper limit for blood storage ...
Cached Medicine News:Health News:Rochester Medical Announces Fourth Quarter 2008 Earnings Conference Call November 6, 2008 2Health News:China Sky One Medical, Inc. Acquires Drug to Treat Breast Lesions 2Health News:China Sky One Medical, Inc. Acquires Drug to Treat Breast Lesions 3Health News:Renowned Kyudo (Zen archery) Master Kanjuro Shibata Sensei to Present in L.A. 2Health News:Response Biomedical Completes Initial Closing of an expected $5.0 Million Financing 2Health News:Response Biomedical Completes Initial Closing of an expected $5.0 Million Financing 3Health News:Response Biomedical Completes Initial Closing of an expected $5.0 Million Financing 4Health News:Majority of voters say election outcome will make a great deal of difference on key issues 2Health News:Majority of voters say election outcome will make a great deal of difference on key issues 3Health News:Older Blood Boosts Chances of Infection in Transfusion Patients 2Health News:Older Blood Boosts Chances of Infection in Transfusion Patients 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: