Navigation Links
Boston University Biomedical Engineers Find Chink in Bacteria's Armor
Date:9/6/2007

limited.

"Importantly, we showed that if you can inhibit or block the bacterial defense mechanisms to hydroxyl radical damage, you can potentiate or enhance the lethality of bactericidal antibiotics. This highlights the value of taking a network biology approach to antibiotics and provides a framework for creating new classes of drugs," said Collins.

"What we think is happening is the cell is getting a signal that says, 'There's something wrong with our energy production system and we need to make more energy.' But, there's really nothing wrong. The cell becomes confused, turns on too many processes at once and it's overwhelmed," said Kohanski.

Previous work by Kohanski and co-lead author Dan Dwyer, a postdoctoral researcher in Collins' lab, revealed the first hints that this underlying pathway exists. In studying bacterial response to a quinolone, an antibiotic that inhibits DNA replication, they noted a surprising change in genes responsible for energy production and iron uptake.

In the current study, the researchers used DNA microarray studies to see if all three classes of bactericidal antibiotics triggered this process. Across the board, they noted increased gene activity along the intracellular assembly lines that make energy for the bacterial cell, just as in the earlier study. They began to deduce the details of the new pathway.

Cells produce free superoxide radicals naturally in oxygen-rich environments, but when they unnecessarily ramp up energy production to a frantic pace - such as when triggered by antibiotics - more radicals get churned out than the cell's safety measures can mop up. The superoxide radicals then pull iron from other components of the cell, and this iron rapidly stimulates production of toxic levels of hydroxyl radicals.

"It's really amazing that despite the diversity of targets, you have everything funneling into this common pathway, where there's a global meltdown occurring," said Dwyer. "The
'/>"/>

SOURCE Boston University College of Engineering
Copyright©2007 PR Newswire.
All rights reserved

0

GOOD

Page: 1 2 3

Related medicine technology :

1. Boston Scientific Announces Schedule for EuroPcr 2007
2. Boston Life Sciences, Inc. Announces Presentation of Cethrin Phase I/IIa 6-Month Results at 75th Annual Meeting of the American Association of Neurological Surgeons
3. Bio-Matrix Scientifics Dr. ONeill Sees University of Pittsburghs Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells
4. Prolexys Pharmaceuticals and Columbia University Researchers Publish Study on Anti-Tumor Properties of a Selective Small Molecule Anti-Tumor Agent With Novel Mechanism of Action
5. Statement by Philip Home Chairman of the RECORD Study Steering Committee and Professor of Diabetes Medicine at Newcastle University in England
6. World First Medical Treatment Announced by Researchers at Queen Mary University London and University of Leicester
7. Alnylam and Stanford University Scientists Discover New Role for microRNAs (miRNAs) in T Cell Biology and Immunity
8. Vaxiion Researchers Discover Novel Vaccine Delivery System in Collaboration with San Diego State University
9. Vical Interim Clinical Results Demonstrate Safety and Tolerability of Inovio Biomedicals Electroporation DNA Delivery Technology
10. Inovio Biomedical Highlights Enhanced DNA Vaccine Potency with Electroporation DNA Delivery Technology and New Devices at Gene Therapy Meeting
11. Inovio Biomedicals DNA Delivery Technology Shows Safety and Enhances Gene Expression & Tumor Responses in Interim Melanoma Clinical Study Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/19/2013)... 2013 /PRNewswire-iReach/ -- In its first major ... company dedicated to advancing development of the ... release drug therapies in patient disease populations ... the acquisition of Enzon Pharmaceutical,s PEGylation Linker ... product pipeline. Acquisition of this technology will ...
(Date:6/19/2013)... , June 19, 2013 Pharma ... new infographic summary of the results from an ... third of all respondents stated that CROs would be an ... of respondents will be running 6 or more clinical trials ... the Clinical Trial Supply USA Summit ...
(Date:6/18/2013)... 2013 Valeant Pharmaceuticals International, Inc. (NYSE: ... today that VPII Escrow Corp., a newly formed wholly ... offer of approximately $3.2 billion aggregate principal amount of ... due in 2021 and in 2023, with final tranching ... use the net proceeds from the offering, together with ...
Breaking Medicine Technology:Belrose Pharma Acquires Enzon's Advanced Drug Formulation Technology and Clinical Assets as Foundation for Driving Development of More Effective Injectable and Sustained Release Therapies 2Belrose Pharma Acquires Enzon's Advanced Drug Formulation Technology and Clinical Assets as Foundation for Driving Development of More Effective Injectable and Sustained Release Therapies 3Belrose Pharma Acquires Enzon's Advanced Drug Formulation Technology and Clinical Assets as Foundation for Driving Development of More Effective Injectable and Sustained Release Therapies 4Pharma IQ Presents the Latest Trends in Clinical Trial Supply 2Valeant Pharmaceuticals Announces Launch Of Private Offering Of Senior Notes 2Valeant Pharmaceuticals Announces Launch Of Private Offering Of Senior Notes 3
... 24 Children,s Mental Focus,Foundation (CMFF), a nonprofit ... that may be linked to children with autism ... currently working with,doctors that have patients afflicted with ... adults cope with behavioral problems,associated with mental disorders ...
... Marketers, who have the,primary responsibility for communicating the ... as top challenges for pharmaceutical,companies when communicating trial ... worry about competitors stealing your,thunder, but also worry ... According to a Best Practices, LLC benchmarking study, ...
Cached Medicine Technology:Children's Mental Focus Foundation Announces a Scientific Breakthrough for Children Who Have Been Diagnosed With Autism, ADD and ADHD 2Children's Mental Focus Foundation Announces a Scientific Breakthrough for Children Who Have Been Diagnosed With Autism, ADD and ADHD 3Clinical Trial Best Practices: Savvy Marketers Plan Ahead with Early Communication Strategies 2
(Date:6/19/2013)... The Cancer Support Community (CSC), an international ... for the whole patient with the launch today of ... This inaugural event, held at the Newseum, will feature ... of Congress members who have made a significant impact ... families currently engaged in the cancer journey. ...
(Date:6/19/2013)... Arem Wellness was developed and is managed ... Ridha Arem, who is determined to help educate the ... Arem Wellness provides a monthly newsletter, a blog, many ... well as an exceptional supplement line uniquely designed by ... role diet and nutrition have not only on ...
(Date:6/19/2013)... to the head; a swift jarring to the body and ... It’s understandable, but what else may follow a concussion injury? ... According to mayoclinic.com , usual symptoms that accompany ... other symptoms may follow, sometimes not for days or weeks ... dizziness, feeling like you’re in a fog, light or noise ...
(Date:6/19/2013)... OR (PRWEB) June 19, 2013 To survive when ... Pilot and Vietnam veteran Captain W.S. “Bud” Orr, the most important ... Speaking to host Sharon Kleyne on the Sharon Kleyne Hour Power ... kit in Vietnam, he always placed extra water ahead of guns ... weight limit on survival kits that pilots could carry on planes ...
(Date:6/19/2013)... CA (PRWEB) June 19, 2013 ... of an Abbreviated New Drug Application (ANDA) for Hydroxyprogesterone ... generic version of Bristol-Myers Squibb’s drug fomerly known as ... to varied inquiries regarding the anticipated approval and market ... product. , Regarding the status of our pending ANDA, ...
Breaking Medicine News(10 mins):Health News:Keeping the Promise of Cancer Care for the Whole Patient 2Health News:Keeping the Promise of Cancer Care for the Whole Patient 3Health News:Arem Wellness Announces a Recipe Contest 2Health News:Arem Wellness Announces a Recipe Contest 3Health News:Concussions Can Lead to Much More Than a Headache, According to MMTR Health Inc. Founder, Terry Moore, Neuromuscular and Cardiovascular Physiologist 2Health News:Vietnam Navy Pilot Reveals to Radio Host Sharon Kleyne That He Carried Extra Water Not a Gun in Survival Kit 2Health News:Current Progress Towards ANDA Approval of Hydroxyprogesterone Caproate Injection, USP 2
... efforts to cut back, , , SATURDAY, April 25 (HealthDay News) ... important lifestyle changes people with heart failure can make, but ... has found. , Researchers asked 116 people with heart ... Though the recommended daily intake of sodium for people with ...
... more potent treatment with fewer side effects , , SATURDAY, ... more direct delivery of cancer drugs to tumors have ... safe, biodegradable polymer, the nanoparticles are chemically engineered to ... most human tumors, and to carry a higher concentration ...
... - Plastic Surgery increased too, with breast implants and ... bank balances and stunning senior celebs are influencing factors.MANCHESTER, ... has been seen by staff at Transform, the UK,s ... Botox Grannies.More and more women over 60 are having ...
... Research , an association of technology analysts, market researchers, and science ... for expanding the pool of associates and tripling of publication schedule ... ... 2009 -- STIX Market Research , an association of technology ...
... a person,s insurance coverage affect their access to quality ... Center, insurance coverage may not only affect a patient,s ... care they receive. Research findings, presented today at the ... a national debate on healthcare reform. , "We ...
... Ill., April 24 World Veterinary Day, April 25, ... farmers. "This year,s theme, ,Veterinarians and Livestock ... partnership, highlights a discipline of veterinary medicine ... said Dr. W. Ron DeHaven, DVM, MBA, Chief Executive ...
Cached Medicine News:Health News:Hidden Salt in Diet Haunts Many With Heart Failure 2Health News:Nanoparticles May Help Attack Cancer More Directly 2Health News:Growth of Plastic Surgery & Botox Grannies in UK 2Health News:Growth of Plastic Surgery & Botox Grannies in UK 3Health News:STIX Market Research Celebrates Ten Years of Technology/Market Analysis, Custom Research, and Niche Publishing; Prepares New Growth Phase 2Health News:STIX Market Research Celebrates Ten Years of Technology/Market Analysis, Custom Research, and Niche Publishing; Prepares New Growth Phase 3Health News:STIX Market Research Celebrates Ten Years of Technology/Market Analysis, Custom Research, and Niche Publishing; Prepares New Growth Phase 4Health News:Does a person's insurance coverage affect their access to quality cancer care? 2Health News:AVMA Celebrates World Veterinary Day 2
The Diagnostic Automation, Inc. (DAI) Measles IgM Enzyme-Linked Immunosorbent Assay (ELISA) is intended for the in vitro determination of IgM antibody to Measles in human serum....
... over 30 years, Digisonics has set ... with the first review station, the ... and the best multi-modality reporting., ,DigiView ... image review workstations, professional reporting choices, ...
... Cortisol is a glucocorticoid produced by ... hormone (ACTH). It is secreted with a ... waking in the morning. Cortisol is often ... of hypertension, stress, AIDS, and in the ...
... IMMULITE 2500 is a high-throughput immunoassay ... ,of the IMMULITE 2000 with the important ... technology ,allows assays to be designed for ... times. ,This allows for critical assays such ...
Medicine Products: