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Boston Scientific's Next-Generation Stent Shows Improved Clinical Outcomes in Complex Lesions
Date:10/22/2007

e TAXUS Liberte Stent compared to 17.8% for the TAXUS Express Stent (p=0.07).

Major adverse cardiac events (MACE) for the TAXUS Liberte 2.25 mm Stent was 12.8% compared to 20.5% for the TAXUS Express Stent (p=0.10), a relative reduction of 38%. All cause death was 1.2% for the TAXUS Liberte 2.25 mm Stent group and 2.7% for the TAXUS Express group (p=0.30). ARC-defined total stent thrombosis to nine months was 0.4% for the TAXUS Liberte 2.25 mm Stent compared to 1.3% for the BMS control (p=0.56) and 1.4% for the TAXUS Express Stent control group (p=0.39).

The TAXUS Liberte Long (38mm) Stent met its primary endpoint of non- inferiority to the TAXUS Express control Stent in percent diameter stenosis (32.6% vs. 31.7%, p=0.71). Overall TVR was 8.7% for the TAXUS Liberte Long Stent compared to 8.5% for the TAXUS Express Stent (p=0.93). Enhanced deliverability was demonstrated through clinical procedural success, which favored the TAXUS Liberte Long Stent over the TAXUS Express Stent (100.0% vs. 96.3%, p=0.0431).

Myocardial infarction (MI) was significantly reduced in TAXUS Liberte Long Stent patients compared to TAXUS Express patients (1.3% vs. 6.3%, p=0.026). The reduction in MI was primarily driven by a decrease in in-hospital Non-Q-Wave MI in the TAXUS Liberte Stent group as compared to the TAXUS Express Stent group (0.0% vs. 4.1%, p=0.013). The MI reduction in TAXUS Liberte Long patients was also reported in a cohort of single stent patients (1.6% vs. 9.1%, p=0.0213).

All cause death was reported as 2.8% for the TAXUS Express Stent and 0.7% for the TAXUS Liberte Long Stent (p=0.21). The TAXUS Liberte Long Stent showed no stent thrombosis at 284 days using either the Protocol Definition or the ARC Definition while the TAXUS Express control Stent reported 0.7% (p=0.49) using the Protocol Definition and 1.4% (p=0.24) using the ARC Definition.

The Company received the CE Mark for the TAXUS Liberte Stent in Europe and other international marke
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SOURCE Boston Scientific Corporation
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