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Boston Scientific's Next-Generation Stent Shows Improved Clinical Outcomes in Complex Lesions
Date:10/22/2007

stent design and a reduction in strut thickness may contribute to improved clinical outcomes for TAXUS Liberte in these difficult and challenging lesions."

"Results from the TAXUS ATLAS studies demonstrate the successful transfer of Boston Scientific's leading paclitaxel technology to our next-generation TAXUS Liberte Stent," said Paul LaViolette, Chief Operating Officer of Boston Scientific. "Improved clinical outcomes and positive data on deliverability in complex lesions are a powerful demonstration of the continued leadership of Boston Scientific and our TAXUS Stent platform. TAXUS Liberte is the preferred drug-eluting stent in virtually every country where it is sold, and we look forward to bringing this technology to the U.S. in 2008."

The TAXUS ATLAS Small Vessel and Long Lesion studies are global, multi- center, historically controlled trials investigating de novo lesions in 411 patients at 24 sites. The Small Vessel study was designed to evaluate the safety and efficacy of the TAXUS Liberte 2.25 mm Stent for superiority compared to a case-matched historical bare-metal stent (BMS) control (Express Stent), and non-inferiority against a case-matched historical control of TAXUS Express Stent patients. The Long Lesion study was designed to demonstrate that the TAXUS Liberte Long (38 mm) Stent is non-inferior in safety and efficacy compared to a case-matched historical control of TAXUS Express Stent patients.

The Small Vessel study met its primary superiority endpoint compared to the BMS group (45.6% vs. 32.1% diameter stenosis, p<0.0001) and non- inferiority compared to the TAXUS Express group (38.4% vs. 32.1% diameter stenosis, p=0.0351). The TAXUS Liberte 2.25 mm Stent showed significant statistical reduction in target lesion revascularization (TLR) at nine months with a rate of 5.8% as compared to 13.7% in the TAXUS Express Stent (p=0.024), resulting in a 58% relative reduction. Overall target vessel revascularization (TVR) was 10.1% for th
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SOURCE Boston Scientific Corporation
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