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Boston Scientific Welcomes Results of Brain Aneurysm Clinical Trial
Date:5/26/2009

Risk of death at five years is lower for aneurysm patients treated with coil embolization compared to surgical clipping

NATICK, Mass., May 26 /PRNewswire-FirstCall/ -- Boston Scientific Corporation (NYSE: BSX) today welcomed publication of results from the ISAT clinical trial in The Lancet Neurology showing patients with a ruptured intracranial aneurysm treated with endovascular coil embolization are 23 percent less likely to die within five years compared to patients who undergo surgical clipping. The findings are reported by Andrew Molyneux, M.D., and Richard Kerr, M.D., from the Neurovascular and Neuroradiology Research Unit of the John Radcliffe Hospital, Oxford, and University of Oxford, U.K.

ISAT is the only multicenter, prospective, randomized controlled clinical trial comparing the safety and efficacy of coil embolization and surgical clipping in the treatment of ruptured brain aneurysms. The latest ISAT data assessed the risk of death and re-bleeding after treatment in more than 2,000 patients with a mean follow-up of nine years.

At five years post-treatment, 14 percent of surgically clipped patients had died compared to 11 percent of patients treated with endovascular coiling, representing a 23 percent relative reduction in risk of death for coiled patients. The percentage of patients characterized as independent in their daily activities at five years post-treatment was similar for both groups (82 percent for coiling versus 81 percent for clipping).

"The recently published ISAT data are reassuring to both patients and physicians," said Dr. Molyneux, Principal Investigator for ISAT. "The risk of late bleeding from a coiled aneurysm is very low, which has been a clinically unanswered question in the medical community. Although there was a slightly greater chance of re-bl
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SOURCE Boston Scientific Corporation
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