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Boston Scientific SYNERGY™ Stent Demonstrates Comparable Safety and Effectiveness Outcomes Versus PROMUS Element™ Platinum Chromium Stent
Date:11/11/2011

MUS Element Stent (p=0.49) and 3.1 percent for the half-dose SYNERGY Stent (p=0.25), all presenting as Non-Q-wave MI.  TLR was 1.1 percent for the SYNERGY Stent, 3.1 percent for the PROMUS Element Stent (p=0.62) and 1.0 percent for the half-dose SYNERGY Stent (p=0.62).

The SYNERGY Stent uses a bioabsorbable PLGA polymer and everolimus drug combination to create an ultra-thin, uniform coating applied to the outer (abluminal) surface of the stent.  After the drug has been delivered, the bioabsorbable coating is designed to resorb within four months, leaving only a bare-metal stent.  This technology is designed to provide the same degree of restenosis reduction as a conventional drug-eluting stent while offering faster and more complete vessel healing after stent implantation, which could potentially reduce the duration of post-procedure dual antiplatelet therapy.  The SYNERGY Stent features the same proprietary platinum chromium alloy and similar stent design used in the PROMUS Element Stent to enable thinner struts, increased conformability, deliverability and flexibility while reducing recoil and improving visibility.

"Our fourth-generation SYNERGY Stent is designed to offer the performance advantages of our innovative platinum chromium platform while significantly reducing the amount of polymer and drug to which the vessel wall is exposed," said Keith D. Dawkins, M.D., Senior Vice President and Chief Medical Officer of Boston Scientific's Cardiology, Rhythm and Vascular Group.  "EVOLVE trial data will be used to support CE Mark approval for SYNERGY, while additional larger studies are planned to further assess clinical event rates and the potential for reduced dual antiplatelet therapy with this novel stent technology.  The SYNERGY Stent demonstrates our ongoing commitment to innovation and clinical science in pursuing the most advanced treatment options for our physician customers and their patients."

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