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Boston Scientific Completes Enrollment in EVOLVE Clinical Trial to Evaluate SYNERGY™ Drug-Eluting Coronary Stent
Date:1/24/2011

NATICK, Mass., Jan. 24, 2011 /PRNewswire/ -- Boston Scientific Corporation (NYSE: BSX) today announced the completion of patient enrollment in the EVOLVE clinical trial, which is designed to assess the safety and performance of the Company's fourth-generation SYNERGY™ Coronary Stent.  The randomized, single-blind, non-inferiority trial will compare the SYNERGY Stent to the PROMUS Element™ Everolimus-Eluting Coronary Stent in patients with a single de novo native coronary artery lesion.  The trial enrolled 291 patients at 29 sites in Europe, Australia and New Zealand, and completed enrollment four months ahead of schedule.  

The SYNERGY Stent uses a bioabsorbable PLGA polymer and everolimus drug combination to create a thin, uniform coating confined to the outer surface of the stent.  Once the drug has been delivered, the bioabsorbable coating resorbs in three to six months, leaving behind only a bare-metal stent.  This technology is designed to provide the same degree of restenosis reduction as a conventional drug-eluting stent while offering faster and more complete vessel healing after stent implantation, which could potentially reduce the duration of required adjunctive medical therapies.  The SYNERGY Stent features the same proprietary platinum chromium alloy and innovative stent design used in the PROMUS Element Stent to enable thinner struts, increased flexibility and a lower profile while reducing recoil and improving radial strength and visibility.

"We are pleased to complete the enrollment phase of the EVOLVE clinical trial well ahead of schedule," said Professor Ian Meredith, M.B.B.S., Ph.D., Director of MonashHeart, Monash Medical Centre, Melbourne, Australia, and Principal Investigator of the trial.  "The brisk pace of enrollment reflects the strong interest in this innovative drug-eluting stent technolog
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