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Bone Biologics Announces Another Major US Patent Issuance for Recombinant Protein Process
Date:3/11/2010

THOUSAND OAKS, Calif., March 11 /PRNewswire/ -- Bone Biologics, Inc. announced today that it has received a US Patent Office Notice of Allowance of patent claims which strongly protects the methods of expressing, secreting, and purifying the NELL-1 sequence of the UCB-1 recombinant protein wherein the mammalian cell line comprises a Chinese hamster ovary (CHO) cell. This patent continues the creation of a patent portfolio for musculoskeletal applications of manufacturing and use in bone regeneration and repair as well as cartilage regeneration and repair.  

Bone Biologics has been developing the protein as a platform technology since 2004, leveraging the previous ten years of research in the lab performed by the company's founding scientists at UCLA.  The mechanism of action is not only identified as to how it works, but why, through this exhaustive research effort. This platform technology is combined with DBX® demineralized bone matrix, to promote bone growth in spinal fusion. DBX® is a product of the Musculoskeletal Transplant Foundation, a Bone Biologics partner.  

The platform technology will be subject to the FDA review and approval process, including clinical trials.  It is not currently approved for use in humans.    

Bruce A. Hazuka, President and CEO of Bone Biologics, Inc. said, "This patent issuance is a significant milestone in our efforts to realize the full potential of the UCB-1 protein as a platform technology. We very much appreciate the continued support of MTF on this project."

"We are pleased to continue our partnership with Bone Biologics," noted Bruce Stroever, CEO of MTF. "This latest patent issuance is a clear sign that the company is continuing to make very good progress toward FDA approval and commercialization of an important product."

Musculoskeletal Transplant Foundation

MTF is a non-profit service organization dedicated to providing quality tissue through a commitment to excellence in education, research, recovery and care for recipients, donors and their families. In 2009, MTF distributed over 415,000 tissue grafts.

Bone Biologics, Inc.

Bone Biologics is a convergence biotechnology company focused in the orthobiologics space.  The company was founded in 2004 by the research scientists who had identified and validated the product in the lab over the previous ten years.  The acquisition of an exclusive worldwide license from UCLA and the both the financing and strategic support from MTF was the genesis of the development of this recombinant protein.

For information: Bruce A. Hazuka/Bone Biologics/818-324-2742

SOURCE Bone Biologics, Inc.

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SOURCE Bone Biologics, Inc.
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