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Boehringer Ingelheim to present new data at ASCO annual meeting regarding its investigational compound afatinib in EGFR-mutation positive patients with advanced NSCLC
Date:5/25/2011

trial evaluating afatinib in NSCLC patients with EGFR mutations, either treatment naïve or after one line of chemotherapy.

Boehringer Ingelheim recently completed enrollment in the phase III LUX-Lung 3 trial that will specifically investigate afatinib as a first-line treatment in patients with advanced NSCLC with EGFR mutations.  Another ongoing phase III trial, LUX-Lung 6, also investigates the efficacy and safety of afatinib compared to standard chemotherapy for first-line treatment of NSCLC patients with EGFR mutations in different geographical regions.

LUX-Lung 4 is a phase I/II trial of afatinib in NSCLC patients who have progressed after conventional EGFR-TKI treatment.  

LUX-Lung 5 is a global phase III trial in patients previously treated with erlotinib or gefitinib. This is the first randomized phase III trial investigating whether patients who initially benefit from treatment with afatinib alone may further benefit from afatinib beyond progression when given in combination with chemotherapy.

About Lung Cancer

Lung cancer is the second most common cancer and kills more people than any other cancer. In 2010, approximately 222,520 new cases of lung cancer were diagnosed in the United States, with 157,300 Americans dying from the disease.  NSCLC is the most common form of lung cancer, accounting for about 85 percent of all lung cancers.(7) Lung cancer remains an area of high unmet need, especially in its advanced stages where it is particularly aggressive and patients have limited treatment options.

About QIAGEN

QIAGEN is the leading global provider of sample and assay technologies. Sample technologies are used to isolate and process DNA, RNA and proteins from biological samples such as blood or tissue. Assay technologies are used to make such isolated bio-molecules visible. QIAGEN has developed and markets more than 500 sample and assay products as well as automated solutions
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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
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