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Boehringer Ingelheim to Launch RE-ALIGN™ Trial to Evaluate Dabigatran Etexilate in Patients with Mechanical Heart Valves
Date:8/26/2011

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(1) RE-ALIGN Presentation. ESC 2011.
(2) NHLBI website. "What is Heart Valve Disease?" Available at: http://www.nhlbi.nih.gov/health/dci/Diseases/hvd/hvd_whatis.html. Accessed on August 18, 2011.
(3) Roger, L.V., et al. "Heart Disease and Stroke Statistics - 2011 Update: A Report From the American Heart Association." Circulation. 2011; 123:e18-e209.
(4) American Heart Association. "Heart Disease and Stroke Statistics - 2008 Update." Dallas, Texas: American Heart Association; 2008.
(5) Butany, J., et al. "Mechanical Heart Valve Prostheses: Identification and Evaluation (erratum)." Cardiovascular Pathology. 2003; 12:322-344.
(6) Bonow, R.O., et al. "ACC/AHA 2006 Practice Guidelines for the Management of Patients With Valvular Heart Disease: Executive Summary. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients with Valvular Heart Disease)." Journal of the American College of Cardiology. 2006; 48:598-675.
(7) Cannegieter, S.C., et al. "Thromboembolic and Bleeding Complications in Patients with Mechanical Heart Valve Prostheses." Circulation. 1994; 89:635-641.
(8) Pradaxa Prescribing Information. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; March 2011.
(9) IMS Health, Custom LRx Study for the period Oct-10 to June-11, excludes Long-Term Care Channel.
(10) Connolly, S.J., et al. "Dabigatran versus Warfarin in Patients with Atrial Fibrillation." New England Journal of Medicine. 2009; 361:1
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