Navigation Links
Boehringer Ingelheim to Launch RE-ALIGN™ Trial to Evaluate Dabigatran Etexilate in Patients with Mechanical Heart Valves
Date:8/26/2011

RIDGEFIELD, Conn., Aug. 26, 2011 /PRNewswire/ -- Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI) today announced plans to launch RE-ALIGN™, a global, Phase II trial evaluating the safety and pharmacokinetics of dabigatran etexilate in 400 patients who have mechanical heart valves.(1) The 12-week study will compare three doses of dabigatran etexilate (150mg bid, 220mg bid and 300mg bid) to warfarin in patients with both aortic valve replacements and mitral valve replacements.(1) A RE-ALIGN extension study will evaluate the ongoing safety of dabigatran etexilate in this patient population for up to 84 months.(1)

Mechanical heart valves are used to treat heart valve disease, which occurs when one or more valves in the heart does not function properly.(2) An estimated 2.5 percent of the American population has heart valve disease.(3) Approximately 100,000 patients undergo heart valve replacement in the U.S. each year,(4) 55 percent of which are mechanical heart valves.(5) Patients with mechanical heart valves require lifelong anticoagulation to help prevent blood clots from forming on or around the valve.(6) A meta-analysis of 46 studies involving patients with mechanical heart valves found the annual incidence of thromboembolism for those who are untreated to be 8.6 percent.(7)

"Boehringer Ingelheim is committed to ongoing research that will expand our understanding of dabigatran etexilate as a treatment option for patients with a variety of cardiovascular and thromboembolic conditions," said John Smith, MD, PhD, senior vice president for clinical development and medical affairs, Boehringer Ingelheim Pharmaceuticals, Inc. "We are proud to announce the launch of RE-ALIGN and plans for a RE-ALIGN extension study, to assess dabigatran etexilate as a potential treatment option to reduce stroke risk in patients with mechanical heart valves."

Dabigatran etexilate was approved by the FDA in October 2010 as the first oral anticoagulant in more
'/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Boehringer Ingelheim and Ashokas Changemakers Launch "Making More Health" Competition
2. Ashoka and Boehringer Ingelheim Announce a Global Partnership for "Making More Health"
3. Zealand Pharma and Boehringer Ingelheim Enter Into a Licence and Collaboration Agreement to Advance Novel Compounds to Treat Type-2 Diabetes and Obesity
4. Boehringer Ingelheim to present new data at ASCO annual meeting regarding its investigational compound afatinib in EGFR-mutation positive patients with advanced NSCLC
5. Positive Phase 2 Results Reported with Boehringer Ingelheims Investigational HCV Protease Inhibitor in Both Previously Treated and Untreated Patients
6. Pfenex Inc. and Boehringer Ingelheim Announce Non-Exclusive Strategic Agreement for the Use of Pfenex Expression Technology™
7. Boehringer Ingelheim to Purchase Amgens Fremont (USA) Facility
8. Boehringer Ingelheim to Purchase Amgens Fremont (California) Facility
9. Reportlinker Adds Boehringer Ingelheim GmbH: PharmaVitae Profile
10. Boehringer Ingelheim Initiates Phase III Clinical Trial With Afatinib in Advanced Breast Cancer
11. Boehringer Ingelheims Pradaxa Available in U.S. Pharmacies Starting Wednesday, November 3
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... Pa. , Sept. 1, 2015 ... fully integrated specialty pharmaceutical company focused on discovering, ... that researchers will be  presenting scientific data on ... an abuse-deterrent, extended-release, oral morphine product candidate, and ... development, at PainWeek 2015 to be ...
(Date:9/1/2015)... 1, 2015 BerGenBio AS ("BerGenBio" ... that it has appointed Hilde Furberg and ... its Board of Directors, effective immediately. ... in pharma and biotech and is currently Senior Vice ... Previously her role was Vice President and General Manager ...
(Date:8/31/2015)... , Aug. 31, 2015  DICOM Grid,  ... today that it was recognized as a semifinalist ... software.  The awards are sponsored by ... related professionals in the medical imaging industry.  Since ... radiology professionals to acknowledge the contributions of their ...
Breaking Medicine Technology:Egalet Announces Scientific Presentations at PainWeek 2015 Meeting 2Egalet Announces Scientific Presentations at PainWeek 2015 Meeting 3Egalet Announces Scientific Presentations at PainWeek 2015 Meeting 4Egalet Announces Scientific Presentations at PainWeek 2015 Meeting 5Egalet Announces Scientific Presentations at PainWeek 2015 Meeting 6BerGenBio Appoints Non-Executive Directors 2DG Suite Nabs "Minnies" Nomination for "Best New Radiology Software" 2
... (Hologic or the Company) (Nasdaq: HOLX ), ... medical imaging systems and surgical products dedicated to serving ... will host a presentation for members of the investment ... America) trade show in Chicago, IL. RSNA is the ...
... SAN DIEGO, Oct. 13 Cardium Therapeutics (NYSE ... new preclinical research findings that Excellagen, a topically ... activates platelet release of platelet-derived growth factor (PDGF) ... has been shown to play an essential role ...
Cached Medicine Technology:Hologic to Host Investor Presentation at RSNA 2010 2Cardium Announces New Research Findings: Excellagen Product Candidate Activates Platelet Release of PDGF, an Important Growth Factor Fundamental to the Wound Healing Process 2Cardium Announces New Research Findings: Excellagen Product Candidate Activates Platelet Release of PDGF, an Important Growth Factor Fundamental to the Wound Healing Process 3Cardium Announces New Research Findings: Excellagen Product Candidate Activates Platelet Release of PDGF, an Important Growth Factor Fundamental to the Wound Healing Process 4Cardium Announces New Research Findings: Excellagen Product Candidate Activates Platelet Release of PDGF, an Important Growth Factor Fundamental to the Wound Healing Process 5Cardium Announces New Research Findings: Excellagen Product Candidate Activates Platelet Release of PDGF, an Important Growth Factor Fundamental to the Wound Healing Process 6Cardium Announces New Research Findings: Excellagen Product Candidate Activates Platelet Release of PDGF, an Important Growth Factor Fundamental to the Wound Healing Process 7
(Date:9/1/2015)... , ... September 01, 2015 , ... ... the release of version 5.2 of the FirstSpirit Content Management System with new ... With the new version of FirstSpirit, companies will be well on their way ...
(Date:9/1/2015)... , ... September 01, 2015 , ... Two of Washington ... cultural relations through food and dining. , Recently named “the next big thing” ... Diotaiuti are known for telling the whole story behind food and reclaiming culinary traditions ...
(Date:9/1/2015)... ... 01, 2015 , ... Suzanne Bakken, PhD, RN, FAAN, FACMI ... of Medicine (IOM) of the National Academies. , She is the Alumni Professor ... A member of the Institute of Medicine since 2006, Bakken also currently co-directs ...
(Date:9/1/2015)... FL (PRWEB) , ... September 01, 2015 , ... ... discount cards, launched its consumer-friendly, informational video this week to coincide with back-to-school ... http://www.USAMedicalCard.com/video . , According to the CDC, elementary school children are sick ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... the MAP Recovery Network, the Premier Outcomes-Driven Provider Network. It is the ... is dedicated to the provision of quality addiction treatment and the utilization ...
Breaking Medicine News(10 mins):Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 3Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 2Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 3Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 4Health News:Columbia Nursing’s Suzanne Bakken Named Distinguished Institute of Medicine Nurse Scholar-in-Residence 2Health News:USA Medical Card Launches New FAQ Video During Back-to-School 2Health News:MAP Health Management Launches the MAP Recovery Network 2
... ... noise and discomfort they experience while wearing their hearing aids. For example, ... disturbing squeals and beeps. In addition, over time, many hearing aids no ... the only solution to these problems has been expensive re-molding or replacement ...
... ... meeting the cleaning equipment needs of the healthcare industry , ... Minneapolis (Vocus) March 2, ... pleased to announce that its Advance Advenger® with EcoFlex System ...
... 2, 2010 New policies that eliminate sugary beverages ... obesity, according to a San Francisco State University study ... the journal Health Affairs . "This is ... whether childhood obesity trends changed after new statewide policies ...
... likelihood of death or readmission to hospital for patients ... a new study in CMAJ ( Canadian ... . The tool, called the LACE index, was ... Institute for Clinical Evaluation Sciences, University of Toronto, University ...
... this week examines why poor countries are falling behind ... that noncommunicable diseases and HIV prevalence are strongly associated ... The Millennium Development Goals (MDGs), which underpin the ... improvements in maternal health, and decreasing the burden of ...
... ... ... , ... , , , ...
Cached Medicine News:Health News:Hearing Aids Wearers Alert! Weber's New Hearing Aids Liner Gives More Comfort Saves Cost Of Re-Molding 2Health News:Advance Advenger with EcoFlex System Wins 2009 Top Product Award 2Health News:Eliminating junk foods at schools may help prevent childhood obesity 2Health News:New tool to predict early death or hospital readmission 2Health News:HIV and noncommunicable diseases hinder the progress of poor countries' Millennium Development Goals 2Health News:Three Houston Defendants Plead Guilty in Connection with "Arthritis Kit" Fraud Scheme 2Health News:Three Houston Defendants Plead Guilty in Connection with "Arthritis Kit" Fraud Scheme 3Health News:Three Houston Defendants Plead Guilty in Connection with "Arthritis Kit" Fraud Scheme 4
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: