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Boehringer Ingelheim Presents Progression-Free Survival Data for Investigational Afatinib and Nintedanib in Advanced NSCLC
Date:5/15/2013

which are types of enzymes measured to determine liver health[7] – as well as diarrhea (3% versus 1%) were observed in patients treated with nintedanib plus pemetrexed.2 Hypertension, bleeding, thrombosis, mucositis and neuropathy (greater than or equal to grade 3) were comparable between the two treatment arms.2 No increase in serious adverse events or grade five adverse events was observed in patients who received the combination of nintedanib plus pemetrexed.2

This study is part of the comprehensive LUME-Lung clinical trial program that is investigating nintedanib in different lung cancer treatment settings. Results from a second trial in the nintedanib LUME-Lung program will be presented on June 3 at ASCO.

About NSCLC and EGFR Mutations

NSCLC is the most common form of lung cancer, accounting for about 85 percent of all diagnoses.8 Between 10 and 15 percent of Caucasians and approximately 40 percent of Asians with NSCLC have EGFR mutations9 – 90 percent of which are the result of two mutations (Del19 or L858R).10

About Afatinib

Afatinib is an investigational, oral, once-daily irreversible ErbB Family Blocker that specifically inhibits epidermal growth factor receptor (EGFR or ErbB1), human epidermal receptor 2 (HER2 or ErbB2) and ErbB4. It is currently in Phase III clinical development in advanced NSCLC and head and neck cancer. The company has submitted applications requesting the review of afatinib for patients with EGFR mutation-positive advanced NSCLC to regulatory authorities in a number of countries and regions worldwide, including the U.S., E.U. and Asia.

Afatinib is not approved by the FDA; its safety and efficacy have not been established. 

About Nintedanib

Nintedanib (BIBF 1120) is an investigational orally-administered triple angiokinase inhibitor that targets three of the receptor
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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
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