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Boehringer Ingelheim Presents Progression-Free Survival Data for Investigational Afatinib and Nintedanib in Advanced NSCLC
Date:5/15/2013

with afatinib discontinued treatment compared with 39.8 percent of patients treated with chemotherapy.1  

LUX-Lung 6 (Patient-Reported Outcomes) Abstract: #8061
Poster: Saturday, June 1, 8:00-11:45 AM, poster board #35A

Patient-reported outcomes (PROs) were also evaluated as secondary endpoints of the LUX-Lung 6 trial and included analyses of health-related quality of life (QoL) and lung cancer-related symptoms compared with chemotherapy.[5]

The analysis of lung cancer-related symptoms – cough, dyspnea (shortness of breath) and pain – was conducted using the European Organization for Research and Treatment of Cancer (EORTC) QoL questionnaire for lung cancer (QLQ-LC13).5 Results showed:

  • A higher proportion of patients in the afatinib arm, compared with those in the chemotherapy arm, reported 10 point or more improvements in cough (76% versus 55%; p=0.0003), dyspnea (71% versus 48%; p<0.0001) and pain (64% versus 47%; p=0.003)5
  • Afatinib-treated patients experienced a significant delay in the worsening (time to deterioration) of cough (HR=0.45; p=0.0001), dyspnea (HR=0.54; p<0.0001) and pain (HR=0.70; p=0.03) compared to those treated with chemotherapy5

Health-related QoL was evaluated using the EORTC QLQ-C30 questionnaire, which evaluated global health status/QoL (overall well-being) in addition to physical, cognitive, role, social and emotional functioning.6 Based on these measures, afatinib-treated patients experienced improvements in their global health-related QoL (p<0.0001) and physical (p<0.0001), role (p=0.01) and social (p<0.001) functioning compared to chemotherapy.5

A significantly higher proportion of afatinib-treated patients had worsening of diarrhea, sore mouth and dysphagia; while fatigue, nausea and vomiting were significantly worse with gemcit
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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
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