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Boehringer Ingelheim Presents Progression-Free Survival Data for Investigational Afatinib and Nintedanib in Advanced NSCLC
Date:5/15/2013

RIDGEFIELD, Conn., May 15, 2013 /PRNewswire/ -- Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI) today announced data from two Phase III clinical trials involving two different investigational oncology compounds – afatinib* and nintedanib* – in two distinct patient populations with advanced non-small cell lung cancer (NSCLC). Results from both studies will be presented at the 49th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, May 31-June 4, 2013.

  • Afatinib was evaluated in the LUX-Lung 6 trial as a first-line treatment in Asian patients with epidermal growth factor receptor (EGFR) mutation-positive advanced NSCLC. Patients treated with afatinib lived for almost a year before their tumor started to grow again (progression-free survival [PFS], the primary endpoint) as compared with just under half a year for patients treated with gemcitabine/cisplatin.[1]
  • Nintedanib was evaluated in combination with pemetrexed in the LUME-Lung 2 trial as a second-line treatment in patients with advanced NSCLC after first-line initial chemotherapy had failed. The study enrollment was halted based on an interim futility analysis. Based on the available data from 713 patients enrolled, an increased PFS was observed in patients treated with the nintedanib combination versus pemetrexed alone.[2]

"The findings from these Phase III trials demonstrate the importance of exploring treatment approaches tailored for the various NSCLC patient populations," said Berthold Greifenberg , MD, vice president, Clinical Development and Medical Affairs, Oncology, Boehringer Ingelheim Pharmaceuticals, Inc. "These important studies demonstrate our commitment to researching new therapies for patients with this devastating disease. Afatinib and nintedanib are two inve
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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
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